SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d7t'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4007_1
(SERUM ALBUMIN)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 8 TYR A 161
LEU A 241
HIS A 201
LEU A 195
 None
 0.98A 1e7cA-6d7tA:
undetectable		 1e7cA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW3_A_ACTA600_0
(HISTONE
METHYLTRANSFERASE
DOT1L)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 5 LEU A 200
VAL A 235
ARG A 190
THR A 198
 None
 1.03A 1nw3A-6d7tA:
2.2		 1nw3A-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B7Z_B_MK1B200_1
(HIV-1 PROTEASE)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 GLY A 395
ALA A 396
ILE A 430
ALA A 457
VAL A 436
 None
 0.87A 2b7zA-6d7tA:
undetectable		 2b7zA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_A_VIAA901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 11 ASN A 464
ILE A 420
ILE A 480
GLN A 483
PHE A 487
 None
 1.23A 2h42A-6d7tA:
undetectable		 2h42A-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2H42_B_VIAB902_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 ASN A 464
ILE A 420
ILE A 480
GLN A 483
PHE A 487
 None
 1.15A 2h42B-6d7tA:
undetectable		 2h42B-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2J2P_E_SC2E1289_1
(FICOLIN-2)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 6 ASP A 227
ARG A 190
ASP A 188
ASP A 223
 None
 1.23A 2j2pE-6d7tA:
undetectable
2j2pF-6d7tA:
undetectable		 2j2pE-6d7tA:
undetectable
2j2pF-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A6D_A_SAMA1350_0
(HYDROXYINDOLE
O-METHYLTRANSFERASE)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 PHE A 487
LEU A 428
GLY A 423
ILE A 420
ALA A 467
 None
None
FZ4  A 801 ( 4.0A)
None
FZ4  A 801 ( 4.2A)
 1.07A 4a6dA-6d7tA:
undetectable		 4a6dA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WH5_A_3QBA204_1
(LINCOSAMIDE
RESISTANCE PROTEIN)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 GLY A 422
HIS A 426
PHE A 468
PHE A 329
GLN A 596
 None
FZ4  A 801 ( 2.5A)
None
None
None
 1.41A 4wh5A-6d7tA:
undetectable		 4wh5A-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ND7_B_TA1B601_1
(TUBULIN BETA-2B
CHAIN)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 ASP A 635
GLU A 634
LEU A 316
ARG A 632
LEU A 277
 None
 0.94A 5nd7B-6d7tA:
undetectable		 5nd7B-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NWW_A_ACAA18_1
(SCRFP-TAG,GP41)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 GLY A 240
LEU A 292
LEU A 293
GLU A 294
LEU A 295
 None
 0.97A 5nwwA-6d7tA:
undetectable		 5nwwA-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5U4S_B_BEZB301_0
(PUTATIVE SHORT CHAIN
DEHYDROGENASE)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 8 ILE A 189
LEU A 219
MET A 215
LEU A 218
 None
 1.04A 5u4sB-6d7tA:
undetectable		 5u4sB-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UO7_A_H4BA802_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 8 SER A 112
MET A  78
PHE A 152
GLU A 113
 None
 1.21A 5uo7A-6d7tA:
0.1
5uo7B-6d7tA:
undetectable		 5uo7A-6d7tA:
undetectable
5uo7B-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_H_RITH602_2
(CYTOCHROME P450 3A5)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		4 / 5 ARG A 470
PHE A 478
LEU A 475
LEU A 592
 FZ4  A 801 ( 3.7A)
None
None
None
 1.36A 5veuH-6d7tA:
undetectable		 5veuH-6d7tA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 6d7t TRANSIENT RECEPTOR
POTENTIAL CATION
CHANNEL SUBFAMILY V
MEMBER 6
(Homo
sapiens) 		5 / 12 MET A 603
SER A 291
GLU A 282
LEU A 293
ILE A 296
 FZ4  A 801 ( 3.5A)
None
None
None
None
 1.27A 5vlmA-6d7tA:
undetectable		 5vlmA-6d7tA:
undetectable