SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3CD2_A_MTXA307_1 (DIHYDROFOLATE REDUCTASE)	6d85	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (Bos taurus)	5 / 12	ILE B 220 LEU B 240 PRO B 199 LEU B 206 ILE B 289	None	1.16A	3cd2A-6d85B: undetectable	3cd2A-6d85B: 18.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3ERD_B_DESB800_1 (ESTROGEN RECEPTOR ALPHA)	6d85	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (Bos taurus)	5 / 10	ALA B 185 LEU B 131 LEU B 165 LEU B 174 MET B 176	None	1.50A	3erdB-6d85B: undetectable	3erdB-6d85B: 16.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3JZ0_B_CLYB900_1 (LINCOSAMIDE NUCLEOTIDYLTRANSFERA SE)	6d85	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (Bos taurus)	4 / 8	GLU B 140 TYR B 150 PHE B 268 ILE B 294	None	0.96A	3jz0B-6d85B: undetectable	3jz0B-6d85B: 15.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5IEN_B_VDYB201_1 (CDL2.2)	6d85	PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA (Bos taurus)	5 / 10	ILE B 294 LEU B 244 VAL B 197 PRO B 199 LEU B 250	None	1.17A	5ienB-6d85B: undetectable	5ienB-6d85B: 21.97

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3CD2_A_MTXA307_1","DIHYDROFOLATE REDUCTASE","6d85","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","Bos taurus",5,"ILE B 220;LEU B 240;PRO B 199;LEU B 206;ILE B 289","None","1.16A","3cd2A-6d85B:undetectable","3cd2A-6d85B:18.72"],["3ERD_B_DESB800_1","ESTROGEN RECEPTOR ALPHA","6d85","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","Bos taurus",5,"ALA B 185;LEU B 131;LEU B 165;LEU B 174;MET B 176","None","1.50A","3erdB-6d85B:undetectable","3erdB-6d85B:16.12"],["3JZ0_B_CLYB900_1","LINCOSAMIDE NUCLEOTIDYLTRANSFERASE","6d85","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","Bos taurus",4,"GLU B 140;TYR B 150;PHE B 268;ILE B 294","None","0.96A","3jz0B-6d85B:undetectable","3jz0B-6d85B:15.49"],["5IEN_B_VDYB201_1","CDL2.2","6d85","PHOSPHATIDYLINOSITOL 3-KINASE REGULATORY SUBUNIT ALPHA","Bos taurus",5,"ILE B 294;LEU B 244;VAL B 197;PRO B 199;LEU B 250","None","1.17A","5ienB-6d85B:undetectable","5ienB-6d85B:21.97"]]