SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d8j'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EGV_B_SAMB1400_0
(UPF0088 PROTEIN
AQ_165)		 6d8j POLYKETIDE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU A  27
THR A  83
LEU A  87
THR A  89
ALA A  88
 None
 1.07A 2egvB-6d8jA:
undetectable		 2egvB-6d8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2EIN_W_CHDW1060_0
(CYTOCHROME C OXIDASE
POLYPEPTIDE
VIIA-HEART
CYTOCHROME C OXIDASE
SUBUNIT 1)		 6d8j POLYKETIDE SYNTHASE
(Mycobacterium
tuberculosis) 		4 / 6 ILE A  65
ARG A  24
THR A  19
LEU A  18
 None
 1.00A 2einN-6d8jA:
undetectable
2einW-6d8jA:
undetectable		 2einN-6d8jA:
undetectable
2einW-6d8jA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DCM_X_SAMX5452_0
(UNCHARACTERIZED
PROTEIN TM_1570)		 6d8j POLYKETIDE SYNTHASE
(Mycobacterium
tuberculosis) 		5 / 11 ALA A  62
LEU A  73
SER A  74
VAL A  75
ALA A  78
 PG4  A 106 ( 3.7A)
None
EDO  A 107 (-3.8A)
None
PG4  A 106 ( 3.5A)
 0.84A 3dcmX-6d8jA:
undetectable		 3dcmX-6d8jA:
undetectable