SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d8w'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_A_715A801_1
(DIPEPTIDYL PEPTIDASE
IV)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLU A  96
TYR A 232
ASN A 230
VAL A 181
HIS A 183
 None
 1.11A 1x70A-6d8wA:
undetectable		 1x70A-6d8wA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1X70_B_715B801_1
(DIPEPTIDYL PEPTIDASE
IV)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLU A  96
TYR A 232
ASN A 230
VAL A 181
HIS A 183
 None
 1.08A 1x70B-6d8wA:
undetectable		 1x70B-6d8wA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_A_BJMA1_1
(DIPEPTIDYL PEPTIDASE
4)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLU A  96
TYR A 232
ASN A 230
VAL A 181
HIS A 183
 None
 1.10A 3bjmA-6d8wA:
undetectable		 3bjmA-6d8wA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJM_B_BJMB2_1
(DIPEPTIDYL PEPTIDASE
4)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		5 / 12 GLU A  96
TYR A 232
ASN A 230
VAL A 181
HIS A 183
 None
 1.10A 3bjmB-6d8wA:
undetectable		 3bjmB-6d8wA:
9.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_B_SALB1345_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 8 LEU A 235
THR A 109
VAL A 110
LEU A 107
 None
 0.94A 3uniB-6d8wA:
undetectable		 3uniB-6d8wA:
4.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQ4_A_SALA601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.87A 4eq4A-6d8wA:
undetectable		 4eq4A-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.89A 4eqlA-6d8wA:
undetectable		 4eqlA-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EQL_B_SALB602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.91A 4eqlB-6d8wA:
undetectable		 4eqlB-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L1A_A_AB1A101_2
(MDR769 HIV-1
PROTEASE)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 ASN A  13
ASP A  16
GLY A 319
THR A 344
 None
 0.95A 4l1aB-6d8wA:
undetectable		 4l1aB-6d8wA:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_A_SALA602_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.93A 4l39A-6d8wA:
undetectable		 4l39A-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L39_B_SALB601_1
(4-SUBSTITUTED
BENZOATES-GLUTAMATE
LIGASE GH3.12)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 LEU A 193
TYR A 194
ILE A 251
GLY A 133
 OXM  A 502 (-4.9A)
None
None
None
 0.92A 4l39B-6d8wA:
undetectable		 4l39B-6d8wA:
8.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MMC_A_29JA603_1
(TRANSPORTER)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		5 / 10 VAL A 444
TYR A 351
GLY A 342
GLY A 352
ASP A 441
 None
 1.45A 4mmcA-6d8wA:
1.0		 4mmcA-6d8wA:
11.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AJQ_A_DB8A800_2
(SERINE/THREONINE-PRO
TEIN KINASE 10)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 VAL A 384
ILE A 377
ASN A 433
VAL A  32
 None
 1.31A 5ajqA-6d8wA:
undetectable		 5ajqA-6d8wA:
17.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 4 LEU A 176
TYR A 147
PRO A 253
ILE A 118
 None
 1.32A 5esgA-6d8wA:
undetectable		 5esgA-6d8wA:
10.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KPC_A_SAMA401_1
(PAVINE
N-METHYLTRANSFERASE)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 5 PHE A 113
SER A 112
ASN A 169
ASP A 237
 None
 1.46A 5kpcA-6d8wA:
undetectable		 5kpcA-6d8wA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 6 GLU A 245
THR A 213
TYR A 200
TYR A 209
 None
 1.14A 5lrbA-6d8wA:
undetectable		 5lrbA-6d8wA:
6.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CI6_A_NBOA607_1
(SERUM ALBUMIN)		 6d8w HEMAGGLUTININ
(Influenza
A
virus) 		4 / 7 ALA A  60
GLU A 101
LYS A 104
LEU A 107
 None
None
OXM  A 503 (-3.6A)
None
 0.87A 6ci6A-6d8wA:
undetectable		 6ci6A-6d8wA:
18.52