SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6d9h'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KGL_A_RTLA175_1
(CELLULAR
RETINOL-BINDING
PROTEIN TYPE I)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 7 LEU R  65
ILE R  95
THR R  91
MET R 180
 None
None
ADN  R 400 (-3.6A)
ADN  R 400 (-4.6A)
 1.24A 1kglA-6d9hR:
undetectable		 1kglA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MMK_A_H4BA1427_1
(PHENYLALANINE-4-HYDR
OXYLASE)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 12 VAL R  83
LEU R  68
HIS R 278
TYR R  12
GLU R  16
 None
None
ADN  R 400 (-4.1A)
None
None
 1.44A 1mmkA-6d9hR:
undetectable		 1mmkA-6d9hR:
13.46
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XVA_A_SAMA293_0
(GLYCINE
N-METHYLTRANSFERASE)		 6d9h GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I) SUBUNIT
ALPHA-2
CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 THR R  44
VAL R 119
GLY A 353
TYR R 288
TYR R 200
 None
 1.29A 1xvaA-6d9hR:
undetectable		 1xvaA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 6d9h GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I) SUBUNIT
ALPHA-2
CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens;
Homo
sapiens) 		3 / 3 PRO R 112
ASN A 348
ARG R 108
 None
 1.05A 2qeuB-6d9hR:
1.7		 2qeuB-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMJ_A_ACRA1001_1
(MALTASE-GLUCOAMYLASE
, INTESTINAL)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I) SUBUNIT
ALPHA-2
(Homo
sapiens) 		5 / 12 ILE R 292
ASP A 351
ARG R 108
ASP R 104
ALA R 100
 None
 1.04A 2qmjA-6d9hR:
undetectable		 2qmjA-6d9hR:
7.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YDO_A_ADNA400_1
(ADENOSINE RECEPTOR
A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		10 / 12 LEU R  88
THR R  91
PHE R 171
GLU R 172
MET R 180
TRP R 247
LEU R 250
ASN R 254
ILE R 274
HIS R 278
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.6A)
ADN  R 400 (-3.8A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
None
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
ADN  R 400 (-4.1A)
 0.83A 2ydoA-6d9hR:
32.7		 2ydoA-6d9hR:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RFM_A_CFFA330_1
(ADENOSINE RECEPTOR
A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		6 / 7 VAL R  87
PHE R 171
MET R 180
LEU R 250
ASN R 254
ILE R 274
 ADN  R 400 (-4.8A)
ADN  R 400 (-3.8A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
 1.04A 3rfmA-6d9hR:
29.6		 3rfmA-6d9hR:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 4 ASN R  27
SER R  94
ALA R  52
VAL R  49
 None
 1.33A 4x1kC-6d9hR:
undetectable		 4x1kC-6d9hR:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Y4D_A_CFFA411_1
(ENDOTHIAPEPSIN)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 6 LEU R  29
PHE R 299
ILE R 292
PHE R 295
 None
 0.93A 4y4dA-6d9hR:
undetectable		 4y4dA-6d9hR:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LJE_A_RTLA201_1
(RETINOL-BINDING
PROTEIN 1)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 6 LEU R  65
ILE R  95
THR R  91
MET R 180
 None
None
ADN  R 400 (-3.6A)
ADN  R 400 (-4.6A)
 1.32A 5ljeA-6d9hR:
undetectable		 5ljeA-6d9hR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 8 LEU R  88
GLU R 172
MET R 180
LEU R 250
ASN R 254
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
 1.19A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 8 LEU R  88
MET R 180
LEU R 250
ASN R 254
ILE R 274
 ADN  R 400 ( 4.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
 0.66A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 8 LEU R  88
PHE R 171
GLU R 172
MET R 180
LEU R 250
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.8A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
 1.19A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZJ_A_TEPA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 8 LEU R  88
PHE R 171
MET R 180
LEU R 250
ILE R 274
 ADN  R 400 ( 4.5A)
ADN  R 400 (-3.8A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 ( 4.9A)
 0.83A 5mzjA-6d9hR:
30.9		 5mzjA-6d9hR:
12.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		7 / 9 ILE R  69
VAL R  87
PHE R 171
MET R 180
LEU R 250
ASN R 254
ILE R 274
 None
ADN  R 400 (-4.8A)
ADN  R 400 (-3.8A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
ADN  R 400 ( 4.9A)
 0.97A 5mzpA-6d9hR:
31.0		 5mzpA-6d9hR:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MZP_A_CFFA2401_1
(ADENOSINE RECEPTOR
A2A,SOLUBLE
CYTOCHROME
B562,ADENOSINE
RECEPTOR A2A)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		5 / 9 PHE R 171
GLU R 172
MET R 180
LEU R 250
ASN R 254
 ADN  R 400 (-3.8A)
ADN  R 400 (-3.5A)
ADN  R 400 (-4.6A)
ADN  R 400 (-4.5A)
ADN  R 400 (-2.9A)
 1.02A 5mzpA-6d9hR:
31.0		 5mzpA-6d9hR:
11.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 4 ASN R  27
SER R  94
ALA R  52
VAL R  49
 None
 1.23A 5nm5A-6d9hR:
undetectable		 5nm5A-6d9hR:
10.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DGX_A_017A101_1
(PROTEASE)		 6d9h GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I) SUBUNIT
ALPHA-2
CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU R  51
ALA R 289
GLY A 353
LEU R  40
ILE R  48
 None
 0.79A 6dgxB-6d9hR:
undetectable		 6dgxB-6d9hR:
23.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DH6_A_017A104_1
(PROTEASE)		 6d9h GUANINE
NUCLEOTIDE-BINDING
PROTEIN G(I) SUBUNIT
ALPHA-2
CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens;
Homo
sapiens) 		5 / 12 LEU R  51
ALA R 289
GLY A 353
LEU R  40
ILE R  48
 None
 0.83A 6dh6B-6d9hR:
undetectable		 6dh6B-6d9hR:
24.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_A_AQ4A602_1
(CYTOCHROME P450 1A1)		 6d9h CHIMERA PROTEIN OF
MUSCARINIC
ACETYLCHOLINE
RECEPTOR M4 AND
ADENOSINE RECEPTOR
A1
(Homo
sapiens) 		4 / 5 ILE R 239
SER R 235
ALA R 289
LEU R  51
 None
 1.07A 6dwnA-6d9hR:
undetectable		 6dwnA-6d9hR:
21.65