SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6da0'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JLF_A_NVPA999_1
(HIV-1 RT A-CHAIN
HIV-1 RT B-CHAIN)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		4 / 8 LEU A 203
TYR A 267
CYH A 271
GLY A 208
 None
None
None
BGC  A 500 (-3.6A)
 1.05A 1jlfA-6da0A:
3.1
1jlfB-6da0A:
4.9		 1jlfA-6da0A:
8.79
1jlfB-6da0A:
9.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1R30_A_SAMA501_0
(BIOTIN SYNTHASE)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		5 / 12 TYR A 259
THR A 127
ASN A 128
ASP A 269
ILE A 258
 None
BGC  A 500 (-3.0A)
BGC  A 500 (-4.0A)
None
None
 1.14A 1r30A-6da0A:
undetectable		 1r30A-6da0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MDR_A_GJZA506_1
(CHOLESTEROL
24-HYDROXYLASE)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		4 / 6 LEU A 145
PHE A 146
ILE A 113
THR A  60
 None
 1.13A 3mdrA-6da0A:
undetectable		 3mdrA-6da0A:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ALB_L_TIQL1210_2
(MEDI2452 LIGHT CHAIN)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		4 / 8 GLY A 206
TYR A 267
ALA A 229
GLY A 210
 ANP  A 501 (-3.4A)
None
None
BGC  A 500 (-3.5A)
 0.82A 5albL-6da0A:
undetectable		 5albL-6da0A:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DV4_A_NMYA601_1
(CCR4-NOT
TRANSCRIPTION
COMPLEX SUBUNIT
6-LIKE)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		5 / 12 LEU A 319
ASN A 155
LEU A 194
PHE A 337
ILE A 164
 None
BGC  A 500 (-3.4A)
None
None
None
 1.25A 5dv4A-6da0A:
undetectable		 5dv4A-6da0A:
10.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4T_B_BEZB306_0
(BETA-LACTAMASE VIM-2)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		3 / 3 HIS A  88
ASN A  91
ALA A  95
 None
 0.30A 5n4tB-6da0A:
undetectable		 5n4tB-6da0A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MXT_A_K5YA1401_0
(ENDOLYSIN, BETA-2
ADRENERGIC RECEPTOR
CHIMERA)		 6da0 GLUCOKINASE
(Naegleria
fowleri) 		5 / 12 VAL A  53
VAL A  55
ASP A 143
PHE A 146
PHE A 136
 None
 1.46A 6mxtA-6da0A:
undetectable		 6mxtA-6da0A:
undetectable