SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6daw'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DB1_A_VDXA428_1
(VITAMIN D NUCLEAR
RECEPTOR)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		5 / 12 LEU A  15
LEU A  18
SER A  21
LEU A 162
HIS A  96
 None
 1.09A 1db1A-6dawA:
undetectable		 1db1A-6dawA:
14.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LIN_A_TFPA154_1
(CALMODULIN)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 7 GLU A  52
LEU A  65
LEU A   7
GLU A  11
 None
 0.95A 1linA-6dawA:
undetectable		 1linA-6dawA:
19.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 6 LEU A  23
ARG A  76
PRO A  91
VAL A 285
 None
 1.03A 2ygoA-6dawA:
undetectable		 2ygoA-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_4
(HIV-1 PROTEASE)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 4 LEU A 162
ASP A  73
VAL A  95
THR A  19
 None
 1.24A 3cyxB-6dawA:
undetectable		 3cyxB-6dawA:
23.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G1B_B_ECNB403_1
(FLAVOHEMOGLOBIN)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		5 / 11 ILE A 244
ALA A 264
LEU A 265
VAL A 180
LEU A 233
 None
 1.02A 4g1bB-6dawA:
undetectable		 4g1bB-6dawA:
10.97
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JTR_A_IBPA401_1
(ALDO-KETO REDUCTASE
FAMILY 1 MEMBER C2)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 8 VAL A 292
TRP A 145
LEU A 190
LEU A 265
 None
 1.06A 4jtrA-6dawA:
undetectable		 4jtrA-6dawA:
16.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		5 / 10 LEU A  53
THR A 104
LEU A 107
LEU A 160
LEU A 283
 None
 1.02A 4z91A-6dawA:
undetectable
4z91B-6dawA:
undetectable
4z91C-6dawA:
undetectable
4z91D-6dawA:
undetectable
4z91E-6dawA:
undetectable		 4z91A-6dawA:
13.62
4z91B-6dawA:
13.62
4z91C-6dawA:
13.62
4z91D-6dawA:
13.62
4z91E-6dawA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z91_E_4LEE401_1
(GAMMA-AMINOBUTYRIC-A
CID RECEPTOR SUBUNIT
BETA-1)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		5 / 10 THR A 104
LEU A 107
LEU A 160
LEU A 283
LEU A  53
 None
 1.00A 4z91A-6dawA:
undetectable
4z91B-6dawA:
undetectable
4z91C-6dawA:
undetectable
4z91D-6dawA:
undetectable
4z91E-6dawA:
undetectable		 4z91A-6dawA:
13.62
4z91B-6dawA:
13.62
4z91C-6dawA:
13.62
4z91D-6dawA:
13.62
4z91E-6dawA:
13.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 6 SER A  63
ASP A 275
GLY A 294
GLU A 142
 None
 1.06A 5cdqA-6dawA:
undetectable
5cdqC-6dawA:
undetectable
5cdqD-6dawA:
undetectable		 5cdqA-6dawA:
10.11
5cdqC-6dawA:
10.11
5cdqD-6dawA:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERG_B_SAMB401_1
(TRNA
(ADENINE(58)-N(1))-M
ETHYLTRANSFERASE
CATALYTIC SUBUNIT
TRM61)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 7 GLY A 281
GLY A  69
ASP A  74
ASP A 282
 None
 0.81A 5ergB-6dawA:
undetectable		 5ergB-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		4 / 6 GLY A 173
THR A 172
VAL A 174
HIS A 146
 None
ACT  A 403 (-2.9A)
None
ARG  A 402 (-3.2A)
 0.94A 5ewuB-6dawA:
undetectable		 5ewuB-6dawA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M50_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		5 / 12 ASP A  74
SER A  93
PRO A  81
ARG A 165
GLY A 304
 None
 1.47A 5m50B-6dawA:
undetectable		 5m50B-6dawA:
12.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BPL_B_PA1B605_1
(LIPID A EXPORT
ATP-BINDING/PERMEASE
PROTEIN MSBA)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		3 / 3 ARG A  89
ARG A 165
ARG A  75
 None
 1.09A 6bplA-6dawA:
undetectable
6bplB-6dawA:
undetectable		 6bplA-6dawA:
21.69
6bplB-6dawA:
21.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA825_0
(GEPHYRIN)		 6daw NON-HEME IRON
HYDROXYLASE
(Streptomyces
lusitanus) 		3 / 3 LYS A 310
VAL A 122
ASP A 124
 None
 0.38A 6fgdA-6dawA:
undetectable		 6fgdA-6dawA:
undetectable