SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6db6'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDT_A_ESTA350_1
(17-BETA-HYDROXYSTERO
ID-DEHYDROGENASE)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 VAL H 109
LEU H  82
HIS H  82
PHE H  63
GLU H  81
 None
 1.18A 1fdtA-6db6H:
undetectable		 1fdtA-6db6H:
15.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JX4_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  38
VAL H  18
PHE H  90
 None
 1.39A 3jx4A-6db6H:
undetectable
3jx4B-6db6H:
undetectable		 3jx4A-6db6H:
12.81
3jx4B-6db6H:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LDO_A_ALEA1402_1
(LYSOZYME, BETA-2
ADRENERGIC RECEPTOR)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 10 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.46A 4ldoA-6db6H:
undetectable		 4ldoA-6db6H:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.98A 4qvyH-6db6H:
undetectable		 4qvyH-6db6H:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.98A 4qvyV-6db6H:
undetectable
4qvyW-6db6H:
undetectable		 4qvyV-6db6H:
15.89
4qvyW-6db6H:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADD_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  38
VAL H  18
PHE H  90
 None
 1.35A 5addA-6db6H:
undetectable
5addB-6db6H:
undetectable		 5addA-6db6H:
12.81
5addB-6db6H:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ADE_A_H4BA760_1
(NITRIC OXIDE
SYNTHASE, BRAIN)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 6 VAL H 111
ARG H  38
VAL H  18
PHE H  90
 None
 1.38A 5adeA-6db6H:
undetectable
5adeB-6db6H:
undetectable		 5adeA-6db6H:
12.81
5adeB-6db6H:
12.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.97A 5bxnH-6db6H:
undetectable
5bxnI-6db6H:
undetectable		 5bxnH-6db6H:
14.36
5bxnI-6db6H:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5D0X_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.96A 5d0xV-6db6H:
undetectable		 5d0xV-6db6H:
15.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.93A 5l5fH-6db6H:
undetectable
5l5fI-6db6H:
undetectable		 5l5fH-6db6H:
15.89
5l5fI-6db6H:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L5F_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 0.94A 5l5fV-6db6H:
undetectable
5l5fW-6db6H:
undetectable		 5l5fV-6db6H:
15.89
5l5fW-6db6H:
17.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.06A 6drzA-6db6H:
undetectable		 6drzA-6db6H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6H7M_B_68HB405_0
(BETA-1 ADRENERGIC
RECEPTOR)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 163
VAL H 182
SER H 180
ASN H 197
ASN H 155
 None
 1.43A 6h7mB-6db6H:
undetectable		 6h7mB-6db6H:
19.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.05A 6hwdH-6db6H:
undetectable
6hwdI-6db6H:
undetectable		 6hwdH-6db6H:
25.00
6hwdI-6db6H:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 6db6 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 311-11D FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 None
 1.05A 6hwdV-6db6H:
undetectable		 6hwdV-6db6H:
25.00