SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6db7'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CBR_A_A80A201_1
(PROTEIN (CRABP-I))		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H  67
LEU H  82
VAL H  18
VAL H 109
LEU H   4
 None
 1.17A 2cbrA-6db7H:
undetectable		 2cbrA-6db7H:
19.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JWQ_B_VIAB901_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
CATALYTIC DOMAIN,
CONE CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE
SUBUNIT ALPHA
CHIMERA)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 TYR H 145
HIS H 200
LEU H 108
ALA H 168
THR H  87
 None
 1.25A 3jwqB-6db7H:
undetectable
3jwqC-6db7H:
undetectable		 3jwqB-6db7H:
12.12
3jwqC-6db7H:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 5 VAL H   2
TYR H  27
ARG H  94
TYR H 102
 None
 0.34A 4m7kH-6db7H:
28.0		 4m7kH-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BXN_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 GOL  H 301 (-4.2A)
GOL  H 303 (-3.2A)
None
None
None
 0.90A 5bxnH-6db7H:
undetectable
5bxnI-6db7H:
undetectable		 5bxnH-6db7H:
15.66
5bxnI-6db7H:
17.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ECN_A_LEUA602_0
(JASMONIC ACID-AMIDO
SYNTHETASE JAR1)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		4 / 7 ALA H  95
TYR H  27
VAL H  78
HIS H  35
 None
 0.86A 5ecnA-6db7H:
1.0		 5ecnA-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DRZ_A_H8JA1206_0
(5HT2B RECEPTOR, BRIL
CHIMERA)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 VAL H 207
THR H 205
VAL H 211
GLY H 118
VAL H 152
 None
 1.07A 6drzA-6db7H:
undetectable		 6drzA-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_B_GLYB709_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
HIV-1 GP120 V3
PEPTIDE FROM MN
STRAIN
(Homo
sapiens;
Human
immunodeficiency
virus
1) 		4 / 5 GLY H  52
ASN H  52
ASP H  53
ARG P 315
 None
 1.27A 6dwdB-6db7H:
undetectable
6dwdD-6db7H:
undetectable		 6dwdB-6db7H:
undetectable
6dwdD-6db7H:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_H_BO2H301_0
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 12 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 GOL  H 301 (-4.2A)
GOL  H 303 (-3.2A)
None
None
None
 0.97A 6hwdH-6db7H:
undetectable
6hwdI-6db7H:
undetectable		 6hwdH-6db7H:
20.69
6hwdI-6db7H:
19.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HWD_V_BO2V301_0
(PROTEASOME SUBUNIT
BETA TYPE-2)		 6db7 HUMAN MONOCLONAL
ANTI-HIV-1 GP120 V3
ANTIBODY 1334 FAB
HEAVY CHAIN
(Homo
sapiens) 		5 / 11 SER H 188
GLY H 134
THR H 135
ALA H 136
THR H 131
 GOL  H 301 (-4.2A)
GOL  H 303 (-3.2A)
None
None
None
 0.97A 6hwdV-6db7H:
undetectable		 6hwdV-6db7H:
20.69