SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dbe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_A_FFOA1293_2
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6dbe NANOBODY VHH R303
(Lama
glama) 		3 / 3 SER A   7
GLU A   6
GLU A   5
 None
 0.61A 1eqbD-6dbeA:
undetectable		 1eqbD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EQB_C_FFOC3293_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6dbe NANOBODY VHH R303
(Lama
glama) 		3 / 3 SER A   7
GLU A   6
GLU A   5
 None
 0.61A 1eqbB-6dbeA:
undetectable		 1eqbB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ASN A  77
VAL A  79
ALA A  98
 None
 0.75A 3qxtA-6dbeA:
20.7		 3qxtA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		7 / 12 LEU A   4
SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
 None
 1.17A 3qxtB-6dbeA:
20.8		 3qxtB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		7 / 12 VAL A   2
LEU A   4
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.66A 3qxtB-6dbeA:
20.8		 3qxtB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXT_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-3 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		7 / 12 VAL A   2
LEU A   4
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.93A 3qxtB-6dbeA:
20.8		 3qxtB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
 None
 1.26A 3qxvA-6dbeA:
20.6		 3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
ASN A  74
ALA A  98
TYR A 107
 None
 1.13A 3qxvA-6dbeA:
20.6		 3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.81A 3qxvA-6dbeA:
20.6		 3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_A_MTXA2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 1.01A 3qxvA-6dbeA:
20.6		 3qxvA-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		5 / 12 ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.72A 3qxvB-6dbeA:
20.5		 3qxvB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
 None
 1.21A 3qxvB-6dbeA:
20.5		 3qxvB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_B_MTXB2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		5 / 12 VAL A   2
ALA A  24
MET A  34
VAL A  79
TYR A 107
 None
 0.84A 3qxvB-6dbeA:
20.5		 3qxvB-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
 None
 1.22A 3qxvD-6dbeA:
20.4		 3qxvD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.77A 3qxvD-6dbeA:
20.4		 3qxvD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 VAL A   2
SER A  30
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 1.03A 3qxvD-6dbeA:
20.4		 3qxvD-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		5 / 12 ALA A  24
MET A  34
VAL A  79
ALA A  98
TYR A 107
 None
 0.78A 3qxvE-6dbeA:
17.1		 3qxvE-6dbeA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_E_MTXE2000_1
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dbe NANOBODY VHH R303
(Lama
glama) 		6 / 12 SER A  30
MET A  34
ARG A  72
VAL A  79
ALA A  98
TYR A 107
 None
 1.18A 3qxvE-6dbeA:
17.1		 3qxvE-6dbeA:
undetectable