SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dbr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1J96_B_TESB904_1
(3ALPHA-HYDROXYSTEROI
D DEHYDROGENASE TYPE
3)		 6dbr -
(-) 		4 / 7 TYR A 950
VAL A 837
GLU A 825
LEU A 904
 None
 0.94A 1j96B-6dbrA:
undetectable		 1j96B-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1K6C_B_MK1B902_1
(POL POLYPROTEIN)		 6dbr -
(-) 		5 / 10 ARG B 159
VAL B 208
ILE B 273
GLY B 275
GLY B 276
 None
 1.06A 1k6cA-6dbrB:
undetectable		 1k6cA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RK3_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 6dbr -
(-) 		4 / 4 LEU A 816
ILE A 968
ARG A 971
TYR A 957
 None
 1.40A 1rk3A-6dbrA:
undetectable		 1rk3A-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BR4_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6dbr

(;
) 		3 / 3 LYS B  38
ASP A 683
ASP A 624
 None
 0.93A 2br4A-6dbrB:
undetectable		 2br4A-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_B_MTXB1272_1
(PTERIDINE REDUCTASE)		 6dbr -
(-) 		5 / 12 PHE B  19
PRO B  17
PHE B 318
LEU B  55
GLU B 341
 None
 1.13A 2c7vB-6dbrB:
undetectable		 2c7vB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2C7V_C_MTXC1272_1
(PTERIDINE REDUCTASE)		 6dbr -
(-) 		5 / 12 PHE B  19
PRO B  17
PHE B 318
LEU B  55
GLU B 341
 None
 1.10A 2c7vC-6dbrB:
undetectable		 2c7vC-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XKW_A_P1BA1478_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6dbr -
(-) 		4 / 7 LEU B 200
ILE B 234
ALA B 263
ILE B 273
 None
 0.75A 2xkwA-6dbrB:
undetectable		 2xkwA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_2
(VITAMIN D3 RECEPTOR)		 6dbr -
(-) 		4 / 5 LEU A 816
ILE A 968
ARG A 971
TYR A 957
 None
 1.40A 2zlcA-6dbrA:
undetectable		 2zlcA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BXO_A_SAMA238_0
(N,N-DIMETHYLTRANSFER
ASE)		 6dbr -
(-) 		5 / 12 ALA B  76
GLY B 139
HIS B 207
LEU B  72
LEU B 106
 None
 1.16A 3bxoA-6dbrB:
undetectable		 3bxoA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FL9_D_TOPD200_1
(DIHYDROFOLATE
REDUCTASE (DHFR))		 6dbr -
(-) 		5 / 9 LEU A 597
VAL A 713
ILE A 649
LEU A 586
PHE A 720
 None
 1.26A 3fl9D-6dbrA:
undetectable		 3fl9D-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PFG_A_SAMA264_0
(N-METHYLTRANSFERASE)		 6dbr -
(-) 		5 / 12 ALA B  76
GLY B 139
HIS B 207
LEU B  72
HIS B  93
 None
 1.08A 3pfgA-6dbrB:
undetectable		 3pfgA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RQW_I_ACHI323_0
(ELIC PENTAMERIC
LIGAND GATED ION
CHANNEL FROM ERWINIA
CHRYSANTHEMI)		 6dbr -
(-) 		4 / 8 TYR A 948
ILE A 829
GLU A 825
TYR A 950
 None
 0.97A 3rqwI-6dbrA:
undetectable
3rqwJ-6dbrA:
undetectable		 3rqwI-6dbrA:
undetectable
3rqwJ-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUD_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6dbr -
(-) 		5 / 12 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.91A 3sudB-6dbrB:
undetectable		 3sudB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUF_B_SUEB1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6dbr -
(-) 		5 / 12 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.98A 3sufB-6dbrB:
undetectable		 3sufB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6dbr -
(-) 		5 / 12 PRO B 134
LEU B 155
LEU B 142
LEU B  91
ILE B 185
 None
 1.07A 4a7aB-6dbrB:
undetectable		 4a7aB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4CX7_D_H4BD600_1
(NITRIC OXIDE
SYNTHASE, INDUCIBLE)		 6dbr -
(-) 		4 / 7 PHE A 611
GLU A 590
MET A 594
ILE A 649
 None
 1.42A 4cx7C-6dbrA:
undetectable
4cx7D-6dbrA:
undetectable		 4cx7C-6dbrA:
undetectable
4cx7D-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FN9_A_STRA301_1
(STEROID RECEPTOR 2)		 6dbr -
(-) 		5 / 12 LEU A 855
LEU A 859
LEU A 865
MET A 871
ALA A 876
 None
 1.11A 4fn9A-6dbrA:
undetectable		 4fn9A-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOI_B_ML1B303_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6dbr -
(-) 		5 / 11 GLY B  95
GLY B  94
ILE B  92
GLY B  18
PHE B 206
 None
 1.08A 4qoiA-6dbrB:
undetectable
4qoiB-6dbrB:
undetectable		 4qoiA-6dbrB:
undetectable
4qoiB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6dbr -
(-) 		4 / 8 THR A 608
GLY A 715
GLY A 714
VAL A 713
 None
 0.57A 4qvvK-6dbrA:
undetectable
4qvvL-6dbrA:
undetectable		 4qvvK-6dbrA:
undetectable
4qvvL-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVV_Y_BO2Y301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6dbr -
(-) 		4 / 8 THR A 608
GLY A 715
GLY A 714
VAL A 713
 None
 0.56A 4qvvY-6dbrA:
undetectable
4qvvZ-6dbrA:
undetectable		 4qvvY-6dbrA:
undetectable
4qvvZ-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTR_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6dbr -
(-) 		5 / 11 TRP A 915
GLY A 976
ASP A 819
ILE A 820
ASN A 822
 None
 1.32A 4rtrA-6dbrA:
undetectable		 4rtrA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XUE_A_SAMA303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6dbr -
(-) 		4 / 5 GLY A 982
TYR A 729
SER A 618
GLU A 981
 None
 1.22A 4xueA-6dbrA:
undetectable		 4xueA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CDQ_F_MFXF2101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT
B,DNA GYRASE SUBUNIT
B)		 6dbr -
(-) 		4 / 6 SER A 712
ASP A 579
ARG A 577
GLY A 532
 None
 1.07A 5cdqA-6dbrA:
2.2
5cdqC-6dbrA:
2.2
5cdqD-6dbrA:
undetectable		 5cdqA-6dbrA:
undetectable
5cdqC-6dbrA:
undetectable
5cdqD-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FSA_A_X2NA590_1
(CYP51 VARIANT1)		 6dbr -
(-) 		5 / 12 LEU A 679
PHE A 681
ILE A 572
PHE A 990
PHE A 576
 None
 1.21A 5fsaA-6dbrA:
undetectable		 5fsaA-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L8O_B_CHDB1001_0
(GASTROTROPIN)		 6dbr

(;
) 		5 / 12 TYR B 138
PHE B 318
VAL B  15
GLN B  16
GLU A 688
 None
 1.42A 5l8oB-6dbrB:
undetectable		 5l8oB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 6dbr -
(-) 		4 / 6 TYR B 277
PHE B 318
THR B 316
GLY B 275
 None
 1.19A 5mraA-6dbrB:
undetectable
5mraB-6dbrB:
undetectable		 5mraA-6dbrB:
undetectable
5mraB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A7P_B_9SCB601_1
(SERUM ALBUMIN)		 6dbr -
(-) 		4 / 6 ASN A 822
PHE A 826
TYR A 950
LEU A 962
 None
 1.37A 6a7pB-6dbrA:
undetectable		 6a7pB-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_A_SUEA1202_0
(NS3 PROTEASE)		 6dbr -
(-) 		5 / 12 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.97A 6c2mA-6dbrB:
undetectable		 6c2mA-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6C2M_B_SUEB1202_0
(NS3 PROTEASE)		 6dbr -
(-) 		5 / 12 PHE B 206
GLY B 139
ILE B 234
GLY B 221
ALA B 209
 None
 0.93A 6c2mB-6dbrB:
undetectable		 6c2mB-6dbrB:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8A_F_ACTF803_0
(UNCHARACTERIZED
PROTEIN)		 6dbr -
(-) 		4 / 4 MET A 763
TYR A 950
ARG A 756
LEU A 958
 None
 1.29A 6d8aF-6dbrA:
0.7		 6d8aF-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8P_B_ACTB803_0
(UNCHARACTERIZED
PROTEIN)		 6dbr -
(-) 		4 / 4 MET A 763
TYR A 950
ARG A 756
LEU A 958
 None
 1.28A 6d8pB-6dbrA:
1.3		 6d8pB-6dbrA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FHW_A_ACRA801_2
(GLUCOAMYLASE P)		 6dbr -
(-) 		3 / 3 TRP B 307
GLU B 286
GLU B 303
 None
 0.99A 6fhwA-6dbrB:
undetectable		 6fhwA-6dbrB:
undetectable