SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dch'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EI6_A_PPFA410_1
(PHOSPHONOACETATE
HYDROLASE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 5 THR A 145
ASP A 134
HIS A 132
HIS A 295
 None
ZN  A 403 (-2.4A)
ZN  A 403 (-3.2A)
ZN  A 403 ( 3.2A)
 1.23A 1ei6A-6dchA:
undetectable		 1ei6A-6dchA:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 7 HIS A 225
SER A 292
ARG A 291
LEU A 293
 None
 1.10A 1ibgL-6dchA:
undetectable		 1ibgL-6dchA:
17.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1UOF_A_PNNA1312_0
(DEACETOXYCEPHALOSPOR
IN C SYNTHETASE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 11 HIS A 132
ASP A 134
THR A 145
HIS A 295
SER A 308
 ZN  A 403 (-3.2A)
ZN  A 403 (-2.4A)
None
ZN  A 403 ( 3.2A)
None
 1.02A 1uofA-6dchA:
5.5		 1uofA-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_C_ACRC701_1
(ALPHA-GLUCOSIDASE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 ILE A  65
ASP A 140
ILE A 323
ASP A 315
HIS A 314
 None
 1.22A 3phaC-6dchA:
undetectable		 3phaC-6dchA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PHA_D_ACRD701_1
(ALPHA-GLUCOSIDASE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 ILE A  65
ASP A 140
ILE A 323
ASP A 315
HIS A 314
 None
 1.34A 3phaD-6dchA:
undetectable		 3phaD-6dchA:
8.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T01_A_PPFA503_1
(PHOSPHONOACETATE
HYDROLASE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 7 THR A 312
ASP A 134
HIS A 295
ILE A 147
 None
ZN  A 403 (-2.4A)
ZN  A 403 ( 3.2A)
None
 1.10A 3t01A-6dchA:
undetectable		 3t01A-6dchA:
15.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD507_1
(HEMOLYTIC LECTIN
CEL-III)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 5 ASP A 289
GLU A 230
TYR A  66
ASP A 315
 None
 1.34A 3w9tD-6dchA:
undetectable		 3w9tD-6dchA:
10.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM0_B_KANB302_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 11 TYR A 168
LEU A 233
THR A 222
LEU A 255
ARG A 258
 None
 1.49A 4em0B-6dchA:
undetectable		 4em0B-6dchA:
27.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M51_A_BEZA501_0
(AMIDOHYDROLASE
FAMILY PROTEIN)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 6 ILE A  58
ILE A 144
PHE A  48
LEU A  86
 None
 0.98A 4m51A-6dchA:
undetectable		 4m51A-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MK4_B_CHDB503_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 11 LEU A  78
LEU A  86
PRO A  93
VAL A 313
VAL A 106
 None
 1.47A 4mk4B-6dchA:
undetectable		 4mk4B-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RET_C_DGXC2005_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 GLU A 281
ASP A 284
LEU A 286
GLU A 154
GLY A 158
 None
 1.16A 4retC-6dchA:
undetectable		 4retC-6dchA:
6.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 GLU A 281
ASP A 284
GLU A 154
GLY A 158
ILE A  70
 None
 1.23A 4xe5A-6dchA:
undetectable		 4xe5A-6dchA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XE5_A_OBNA1104_1
(SODIUM/POTASSIUM-TRA
NSPORTING ATPASE
SUBUNIT ALPHA-1)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 GLU A 281
ASP A 284
LEU A 286
GLU A 154
GLY A 158
 None
 1.03A 4xe5A-6dchA:
undetectable		 4xe5A-6dchA:
6.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_A_ACTA401_0
(PROTON-GATED ION
CHANNEL)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 6 ILE A 275
PHE A 270
ARG A 296
GLU A 268
 None
 1.20A 4zzcA-6dchA:
undetectable
4zzcB-6dchA:
undetectable		 4zzcA-6dchA:
undetectable
4zzcB-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZZC_B_ACTB401_0
(PROTON-GATED ION
CHANNEL)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 6 ILE A 275
PHE A 270
ARG A 296
GLU A 268
 None
 1.14A 4zzcB-6dchA:
undetectable
4zzcC-6dchA:
undetectable		 4zzcB-6dchA:
undetectable
4zzcC-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KC4_E_RBFE201_2
(RIBOFLAVIN
TRANSPORTER RIBU)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		3 / 3 LYS A 318
ASP A 321
ILE A 144
 None
 0.76A 5kc4E-6dchA:
undetectable		 5kc4E-6dchA:
22.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CB4_A_BEZA501_0
(CANAVALIN)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		4 / 8 LEU A  86
VAL A 313
LEU A  90
ILE A 144
 None
 0.95A 6cb4A-6dchA:
2.9		 6cb4A-6dchA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DCH_A_ACTA401_0
(SCOE PROTEIN)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 5 THR A 127
HIS A 132
ASP A 134
HIS A 295
ARG A 310
 ACT  A 401 ( 4.9A)
ZN  A 403 (-3.2A)
ZN  A 403 (-2.4A)
ZN  A 403 ( 3.2A)
CL  A 402 (-3.1A)
 0.06A 6dchA-6dchA:
52.1		 6dchA-6dchA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DJZ_C_GMJC301_0
(SIGMA NON-OPIOID
INTRACELLULAR
RECEPTOR 1)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		5 / 12 ALA A  71
LEU A 285
VAL A 111
VAL A 106
LEU A  90
 None
 1.00A 6djzC-6dchA:
1.6		 6djzC-6dchA:
22.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECF_I_DVAI3010_0
(VLM2
DODECADEPSIPEPTIDE)		 6dch SCOE PROTEIN
(Streptomyces
coeruleorubidus) 		3 / 3 PHE A  48
ARG A  89
ALA A  56
 None
 0.92A 6ecfB-6dchA:
undetectable		 6ecfB-6dchA:
21.35