SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dcl'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SG9_A_SAMA301_0
(HEMK PROTEIN)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		5 / 12 ILE A 112
GLY A 172
THR A 116
GLU A 114
ASN A 174
 None
None
None
U  D   7 ( 3.5A)
None
 1.20A 1sg9A-6dclA:
undetectable		 1sg9A-6dclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y05_A_RALA801_1
(PROSTAGLANDIN
REDUCTASE 1)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		4 / 8 ARG A 178
VAL A 170
TYR A 124
VAL A 177
 U  D   8 ( 3.0A)
None
None
None
 1.21A 2y05A-6dclA:
undetectable
2y05B-6dclA:
undetectable		 2y05A-6dclA:
12.90
2y05B-6dclA:
12.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NUK_A_Z80A201_1
(BETA-LACTOGLOBULIN)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		5 / 10 PHE A 125
LYS A 130
ILE A 131
ILE A 134
ALA A 180
 None
None
None
None
A  D   9 ( 3.9A)
 1.07A 5nukA-6dclA:
undetectable		 5nukA-6dclA:
17.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWT_D_BEZD202_0
(PR 10 PROTEIN)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		3 / 3 PHE A 153
ASP A 157
LYS A 161
 None
 0.88A 6awtD-6dclA:
undetectable		 6awtD-6dclA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BRD_C_RFPC502_1
(RIFAMPIN
MONOOXYGENASE)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		5 / 12 GLY A 110
VAL A 109
PHE A 125
THR A 169
GLY A 172
 U  D   8 ( 3.4A)
None
None
None
None
 1.16A 6brdC-6dclA:
undetectable		 6brdC-6dclA:
18.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D8F_A_ACTA803_0
(UNCHARACTERIZED
PROTEIN)		 6dcl HETEROGENEOUS
NUCLEAR
RIBONUCLEOPROTEIN A1
(Homo
sapiens) 		3 / 3 GLU A   9
LEU A  13
ARG A  88
 None
 0.81A 6d8fA-6dclA:
2.7		 6d8fA-6dclA:
undetectable