SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dcq'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.98A 1dhiA-6dcqA:
undetectable		 1dhiA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.98A 1dhiB-6dcqA:
undetectable		 1dhiB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 1dhjA-6dcqA:
undetectable		 1dhjA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.98A 1dhjB-6dcqA:
undetectable		 1dhjB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRA_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.98A 1draA-6dcqA:
undetectable		 1draA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.99A 1drbA-6dcqA:
undetectable		 1drbA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.00A 1drbB-6dcqA:
undetectable		 1drbB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 6dcq IMMUNOGLOBULIN G
PGT151 FAB, LIGHT
CHAIN
(Homo
sapiens) 		4 / 5 GLY L  64
LEU L  73
THR L  72
VAL L  48
 None
 0.90A 1ekjF-6dcqL:
undetectable
1ekjG-6dcqL:
undetectable		 1ekjF-6dcqL:
undetectable
1ekjG-6dcqL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RA3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.96A 1ra3A-6dcqA:
undetectable		 1ra3A-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.94A 1rb3B-6dcqA:
undetectable		 1rb3B-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RD7_B_FOLB361_0
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.00A 1rd7B-6dcqA:
undetectable		 1rd7B-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RX7_A_FOLA161_0
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 1.00A 1rx7A-6dcqA:
undetectable		 1rx7A-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.96A 2d0kB-6dcqA:
undetectable		 2d0kB-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.98A 2drcA-6dcqA:
undetectable		 2drcA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DRC_B_MTXB161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 2drcB-6dcqA:
undetectable		 2drcB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_A_9CRA501_1
(CYTOCHROME P450 2C8)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 SER B 528
ALA A 497
THR A  37
VAL A  42
PRO A  43
 NAG  A 615 (-4.5A)
None
None
None
None
 1.12A 2nnhA-6dcqB:
undetectable		 2nnhA-6dcqB:
10.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 3drcA-6dcqA:
undetectable		 3drcA-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DRC_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 3drcB-6dcqA:
undetectable		 3drcB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_A_CHDA151_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 7 ILE A 455
GLY A 473
LEU A 285
ARG A 480
 None
 0.85A 3elzA-6dcqA:
undetectable		 3elzA-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7H_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 ARG A 350
THR A 394
TRP A 395
 None
 1.28A 4d7hA-6dcqA:
undetectable		 4d7hA-6dcqA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_B_MTXB162_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.99A 4dfrB-6dcqA:
undetectable		 4dfrB-6dcqA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4I13_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 4i13A-6dcqA:
undetectable		 4i13A-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K39_A_SAMA504_0
(ANAEROBIC
SULFATASE-MATURATING
ENZYME)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 PHE A 391
ASN A 332
VAL A 292
ILE A 449
LEU A 452
 None
NAG  A 603 ( 2.1A)
None
None
None
 1.36A 4k39A-6dcqA:
undetectable		 4k39A-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KN2_C_LYAC304_2
(FOLATE RECEPTOR BETA)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 TYR B 644
GLN B 652
TRP B 596
 None
 1.13A 4kn2C-6dcqB:
undetectable		 4kn2C-6dcqB:
14.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P66_A_MTXA201_1
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 11 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.93A 4p66A-6dcqA:
undetectable		 4p66A-6dcqA:
16.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4W5N_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		4 / 6 ILE A 323
LEU A 154
GLU A 153
TYR A 177
 None
 0.97A 4w5nA-6dcqA:
undetectable		 4w5nA-6dcqA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G6C_A_H4BA902_1
(NITRIC OXIDE
SYNTHASE OXYGENASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		3 / 3 ARG A 350
THR A 394
TRP A 395
 None
 1.27A 5g6cA-6dcqA:
undetectable		 5g6cA-6dcqA:
12.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K9D_A_ACTA405_0
(DIHYDROOROTATE
DEHYDROGENASE
(QUINONE),
MITOCHONDRIAL)		 6dcq IMMUNOGLOBULIN G
PGT151 FAB, LIGHT
CHAIN
(Homo
sapiens) 		3 / 3 GLN L  90
THR L  97
ASP L   1
 None
 0.92A 5k9dA-6dcqL:
undetectable		 5k9dA-6dcqL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6dcq ENVELOPE
GLYCOPROTEIN GP160
(Human
immunodeficiency
virus
1) 		5 / 12 ILE A 215
ALA A  55
LEU A  52
LEU A 483
ILE A 251
 None
 0.97A 5ujxA-6dcqA:
undetectable		 5ujxA-6dcqA:
undetectable