SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dd3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_A_ADNA1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 11 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.33A 1odiA-6dd3A:
undetectable		 1odiA-6dd3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_B_ADNB1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 11 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.33A 1odiB-6dd3A:
undetectable		 1odiB-6dd3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_C_ADNC1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 11 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.33A 1odiC-6dd3A:
undetectable		 1odiC-6dd3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_E_ADNE1237_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 11 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.28A 1odiE-6dd3A:
undetectable		 1odiE-6dd3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ODI_F_ADNF1238_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 11 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.31A 1odiF-6dd3A:
undetectable		 1odiF-6dd3A:
16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Q23_A_FUAA702_1
(CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 12 VAL A  35
PHE A 369
ALA A 376
ALA A 463
HIS A  33
 None
 1.23A 1q23A-6dd3A:
undetectable
1q23B-6dd3A:
undetectable		 1q23A-6dd3A:
16.89
1q23B-6dd3A:
16.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TYR A 210
SER A 251
TYR A 255
TYR A  60
 None
PO4  A 601 ( 4.0A)
None
None
 1.07A 2bteD-6dd3A:
undetectable		 2bteD-6dd3A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 ASP A 145
THR A 147
PHE A 354
GLN A 453
 None
None
None
PO4  A 602 (-4.1A)
 0.90A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JC9_A_ADNA1497_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 7 THR A 147
ILE A 152
ASN A 154
PHE A 354
GLN A 453
 None
None
None
None
PO4  A 602 (-4.1A)
 0.70A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
2JC9_A_ADNA1498_1
(CYTOSOLIC PURINE
5'-NUCLEOTIDASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 5 PHE A 127
ARG A 129
HIS A 428
MET A 432
MET A 436
 None
PO4  A 603 ( 4.9A)
None
None
None
 0.44A 2jc9A-6dd3A:
61.2		 2jc9A-6dd3A:
79.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_B_CLUB809_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 ALA A  58
TYR A  55
ASP A  54
TYR A 255
 None
None
PO4  A 601 (-3.8A)
None
 1.37A 2pncB-6dd3A:
undetectable		 2pncB-6dd3A:
7.65
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		3 / 3 ASN A 158
ARG A  98
ASP A 356
 None
None
PO4  A 601 ( 4.9A)
 0.89A 2qe6A-6dd3A:
undetectable		 2qe6A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		3 / 3 ASN A 158
ARG A  98
ASP A 356
 None
None
PO4  A 601 ( 4.9A)
 0.90A 2qe6B-6dd3A:
undetectable		 2qe6B-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_A_ACTA141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		3 / 3 VAL A 205
ASP A 206
GLU A 161
 None
 0.54A 2qeuA-6dd3A:
undetectable		 2qeuA-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_C_ACTC141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		3 / 3 VAL A 205
ASP A 206
GLU A 161
 None
 0.53A 2qeuC-6dd3A:
undetectable		 2qeuC-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RLF_B_RIMB299_1
(MATRIX PROTEIN 2)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 LEU A 392
LEU A 388
ILE A 423
ARG A 422
 None
 1.10A 2rlfB-6dd3A:
undetectable
2rlfC-6dd3A:
undetectable		 2rlfB-6dd3A:
17.95
2rlfC-6dd3A:
17.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0M_B_KLNB1498_1
(CYTOCHROME P450 3A4)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 9 PHE A 450
ALA A 166
GLU A 374
GLY A  99
LEU A 100
 None
 1.26A 2v0mB-6dd3A:
undetectable		 2v0mB-6dd3A:
9.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_A_P1ZA1352_1
(PROSTAGLANDIN
REDUCTASE 2)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 TYR A 262
TYR A  60
LEU A 263
TYR A 255
 None
 1.40A 2w98A-6dd3A:
2.6
2w98B-6dd3A:
2.5		 2w98A-6dd3A:
12.38
2w98B-6dd3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W98_B_P1ZB1358_1
(PROSTAGLANDIN
REDUCTASE 2)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 ASP A 351
TYR A  55
PHE A  51
LEU A 232
 PO4  A 601 ( 4.6A)
None
None
None
 1.23A 2w98A-6dd3A:
2.5
2w98B-6dd3A:
2.5		 2w98A-6dd3A:
12.38
2w98B-6dd3A:
12.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 ASP A  54
SER A 251
TYR A 253
TRP A 279
 PO4  A 601 (-3.8A)
PO4  A 601 ( 4.0A)
None
None
 1.21A 2xz5A-6dd3A:
undetectable
2xz5C-6dd3A:
undetectable		 2xz5A-6dd3A:
undetectable
2xz5C-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_C_CHDC525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TRP A 279
ASP A 306
THR A 307
LEU A 312
 None
None
None
GOL  A 605 (-4.7A)
 1.00A 3ablA-6dd3A:
2.8
3ablC-6dd3A:
undetectable
3ablP-6dd3A:
undetectable		 3ablA-6dd3A:
undetectable
3ablC-6dd3A:
undetectable
3ablP-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ABL_P_CHDP1525_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 LEU A 312
TRP A 279
ASP A 306
THR A 307
 GOL  A 605 (-4.7A)
None
None
None
 1.01A 3ablC-6dd3A:
undetectable
3ablN-6dd3A:
undetectable
3ablP-6dd3A:
undetectable		 3ablC-6dd3A:
undetectable
3ablN-6dd3A:
undetectable
3ablP-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3E23_A_SAMA221_0
(UNCHARACTERIZED
PROTEIN RPA2492)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 12 GLY A 438
GLY A 444
SER A 443
LEU A 392
HIS A 428
 None
 1.13A 3e23A-6dd3A:
undetectable		 3e23A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF201_1
(PROTEIN S100-A4)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 5 MET A  53
PHE A  51
PHE A 283
PHE A 264
 None
 1.22A 3ko0F-6dd3A:
undetectable
3ko0G-6dd3A:
undetectable		 3ko0F-6dd3A:
19.54
3ko0G-6dd3A:
19.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3R6W_A_NFZA214_1
(FMN-DEPENDENT
NADH-AZOREDUCTASE 1)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 10 PHE A  89
VAL A 201
PHE A 102
GLY A 124
ASN A 108
 None
 1.38A 3r6wA-6dd3A:
1.6
3r6wB-6dd3A:
undetectable		 3r6wA-6dd3A:
20.00
3r6wB-6dd3A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_A_ACTA604_0
(GBAA_1210 PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 GLY A  69
VAL A 205
HIS A 209
THR A  73
 None
 1.07A 3tj7A-6dd3A:
undetectable
3tj7B-6dd3A:
undetectable		 3tj7A-6dd3A:
undetectable
3tj7B-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC606_0
(GBAA_1210 PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 GLY A  69
VAL A 205
HIS A 209
THR A  73
 None
 1.05A 3tj7C-6dd3A:
undetectable
3tj7D-6dd3A:
undetectable		 3tj7C-6dd3A:
undetectable
3tj7D-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_D_ACTD605_0
(GBAA_1210 PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 VAL A 205
HIS A 209
THR A  73
GLY A  69
 None
 1.02A 3tj7C-6dd3A:
undetectable
3tj7D-6dd3A:
undetectable		 3tj7C-6dd3A:
undetectable
3tj7D-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 10 ARG A  98
GLY A 350
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.30A 3uayA-6dd3A:
undetectable		 3uayA-6dd3A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UAY_A_ADNA236_1
(PURINE NUCLEOSIDE
PHOSPHORYLASE
DEOD-TYPE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 10 GLY A 350
VAL A 371
GLU A 374
ASN A  52
ILE A 349
 None
None
None
PO4  A 601 (-3.6A)
None
 1.28A 3uayA-6dd3A:
undetectable		 3uayA-6dd3A:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 THR A 155
TYR A  60
TYR A  55
ARG A  98
 None
 1.35A 3wipA-6dd3A:
undetectable
3wipB-6dd3A:
undetectable		 3wipA-6dd3A:
undetectable
3wipB-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_A_ACHA301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.22A 3wipA-6dd3A:
undetectable
3wipB-6dd3A:
undetectable		 3wipA-6dd3A:
undetectable
3wipB-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  60
TYR A  55
ARG A  98
 None
 1.39A 3wipB-6dd3A:
undetectable
3wipC-6dd3A:
undetectable		 3wipB-6dd3A:
undetectable
3wipC-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_B_ACHB301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.28A 3wipB-6dd3A:
undetectable
3wipC-6dd3A:
undetectable		 3wipB-6dd3A:
undetectable
3wipC-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  60
TYR A  55
ARG A  98
 None
 1.39A 3wipC-6dd3A:
undetectable
3wipD-6dd3A:
undetectable		 3wipC-6dd3A:
undetectable
3wipD-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_C_ACHC301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.27A 3wipC-6dd3A:
undetectable
3wipD-6dd3A:
undetectable		 3wipC-6dd3A:
undetectable
3wipD-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  60
TYR A  55
ARG A  98
 None
 1.39A 3wipD-6dd3A:
undetectable
3wipE-6dd3A:
undetectable		 3wipD-6dd3A:
undetectable
3wipE-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.26A 3wipD-6dd3A:
undetectable
3wipE-6dd3A:
undetectable		 3wipD-6dd3A:
undetectable
3wipE-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_E_ACHE301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 ARG A  98
THR A 155
TYR A  60
TYR A  55
 None
 1.37A 3wipA-6dd3A:
undetectable
3wipE-6dd3A:
undetectable		 3wipA-6dd3A:
undetectable
3wipE-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_F_ACHF301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 THR A 155
TYR A  60
TYR A  55
ARG A  98
 None
 1.34A 3wipF-6dd3A:
undetectable
3wipG-6dd3A:
undetectable		 3wipF-6dd3A:
undetectable
3wipG-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACHG301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 THR A 155
TYR A  65
TYR A  55
ARG A  98
 None
 1.25A 3wipG-6dd3A:
undetectable
3wipH-6dd3A:
undetectable		 3wipG-6dd3A:
undetectable
3wipH-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_G_ACTG305_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		3 / 3 ASP A 429
ARG A 422
LYS A 425
 None
 1.10A 3wipG-6dd3A:
undetectable		 3wipG-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_J_ACHJ301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 ARG A  98
THR A 155
TYR A  65
TYR A  55
 None
 1.26A 3wipF-6dd3A:
undetectable
3wipJ-6dd3A:
undetectable		 3wipF-6dd3A:
undetectable
3wipJ-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7T_A_5FWA1000_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 LYS A   3
PRO A  63
LYS A  61
GLU A  64
 None
 1.30A 4a7tA-6dd3A:
undetectable		 4a7tA-6dd3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7U_A_ALEA1001_1
(SUPEROXIDE DISMUTASE
[CU-ZN])		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 6 LYS A   3
PRO A  63
LYS A  61
GLU A  64
 None
 1.26A 4a7uA-6dd3A:
undetectable		 4a7uA-6dd3A:
18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M6T_A_SAMA201_0
(RNA POLYMERASE
II-ASSOCIATED FACTOR
1 HOMOLOG, LINKER,
RNA
POLYMERASE-ASSOCIATE
D PROTEIN LEO1)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 4 ILE A 142
VAL A 120
VAL A 112
ARG A 144
 None
None
None
PO4  A 602 (-3.9A)
 1.25A 4m6tA-6dd3A:
undetectable		 4m6tA-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MUB_A_OAQA302_0
(SULFOTRANSFERASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 12 HIS A 209
PHE A 157
GLY A 350
ASP A 356
THR A  56
 None
None
None
PO4  A 601 ( 4.9A)
None
 1.08A 4mubA-6dd3A:
undetectable		 4mubA-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R3A_A_RBFA402_1
(BLUE-LIGHT-ACTIVATED
HISTIDINE KINASE 2)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 12 GLN A 280
ILE A 259
ILE A 286
LEU A 247
MET A  53
 None
None
GOL  A 606 ( 4.6A)
None
None
 1.11A 4r3aA-6dd3A:
undetectable		 4r3aA-6dd3A:
14.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5B1B_C_CHDC307_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TRP A 279
ASP A 306
THR A 307
LEU A 312
 None
None
None
GOL  A 605 (-4.7A)
 0.98A 5b1bA-6dd3A:
2.3
5b1bC-6dd3A:
undetectable
5b1bP-6dd3A:
undetectable		 5b1bA-6dd3A:
undetectable
5b1bC-6dd3A:
undetectable
5b1bP-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 LEU A 312
TRP A 279
ASP A 306
THR A 307
 GOL  A 605 (-4.7A)
None
None
None
 0.98A 5iy5C-6dd3A:
undetectable
5iy5N-6dd3A:
3.1
5iy5P-6dd3A:
undetectable		 5iy5C-6dd3A:
undetectable
5iy5N-6dd3A:
undetectable
5iy5P-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_A_CVIA608_0
(ACETYLCHOLINESTERASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 7 ASP A 103
THR A 104
LEU A 105
TYR A 137
 None
 0.88A 5ov9A-6dd3A:
undetectable		 5ov9A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OV9_B_CVIB602_0
(ACETYLCHOLINESTERASE)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 ASP A 103
THR A 104
LEU A 105
TYR A 137
 None
 0.92A 5ov9B-6dd3A:
undetectable		 5ov9B-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UL4_A_SAMA803_0
(OXSB PROTEIN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		5 / 12 GLY A 438
LYS A 111
GLY A 435
GLU A  66
LEU A 156
 None
 1.03A 5ul4A-6dd3A:
2.7		 5ul4A-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W97_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TRP A 279
ASP A 306
THR A 307
LEU A 312
 None
None
None
GOL  A 605 (-4.7A)
 1.00A 5w97A-6dd3A:
undetectable
5w97C-6dd3A:
undetectable
5w97c-6dd3A:
undetectable		 5w97A-6dd3A:
undetectable
5w97C-6dd3A:
undetectable
5w97c-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WAU_C_CHDC301_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TRP A 279
ASP A 306
THR A 307
LEU A 312
 None
None
None
GOL  A 605 (-4.7A)
 1.03A 5wauA-6dd3A:
3.3
5wauC-6dd3A:
undetectable
5wauc-6dd3A:
undetectable		 5wauA-6dd3A:
undetectable
5wauC-6dd3A:
undetectable
5wauc-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X19_C_CHDC305_0
(CYTOCHROME C OXIDASE
SUBUNIT 1
CYTOCHROME C OXIDASE
SUBUNIT 3)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 8 TRP A 279
ASP A 306
THR A 307
LEU A 312
 None
None
None
GOL  A 605 (-4.7A)
 0.94A 5x19A-6dd3A:
2.2
5x19C-6dd3A:
undetectable
5x19P-6dd3A:
undetectable		 5x19A-6dd3A:
undetectable
5x19C-6dd3A:
undetectable
5x19P-6dd3A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AWV_A_BEZA202_0
(ARA H 8 ALLERGEN)		 6dd3 CYTOSOLIC PURINE
5'-NUCLEOTIDASE
(Homo
sapiens) 		4 / 4 PHE A 283
ASP A 284
LEU A 236
LYS A 240
 None
 1.10A 6awvA-6dd3A:
undetectable		 6awvA-6dd3A:
undetectable