SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dde'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1C4D_C_DVAC6_0
(GRAMICIDIN A)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		3 / 3 ALA R 184
VAL R 189
TRP R 192
 None
 0.94A 1c4dC-6ddeR:
undetectable
1c4dD-6ddeR:
undetectable		 1c4dC-6ddeR:
undetectable
1c4dD-6ddeR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_A_URFA1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		4 / 6 ASN R 191
ILE R 186
ASN R 183
THR R 160
 None
 1.17A 1h7xA-6ddeR:
undetectable		 1h7xA-6ddeR:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_B_URFB1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		4 / 6 ASN R 191
ILE R 186
ASN R 183
THR R 160
 None
 1.19A 1h7xB-6ddeR:
undetectable		 1h7xB-6ddeR:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_C_URFC1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		4 / 6 ASN R 191
ILE R 186
ASN R 183
THR R 160
 None
 1.17A 1h7xC-6ddeR:
undetectable		 1h7xC-6ddeR:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H7X_D_URFD1033_1
(DIHYDROPYRIMIDINE
DEHYDROGENASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		4 / 6 ASN R 191
ILE R 186
ASN R 183
THR R 160
 None
 1.18A 1h7xD-6ddeR:
undetectable		 1h7xD-6ddeR:
5.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNJ_A_225A501_1
(CYTOCHROME P450 2C8)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		5 / 10 LEU R 158
VAL R 288
ALA R 287
ILE R 248
VAL R 245
 None
 1.06A 2nnjA-6ddeR:
0.9		 2nnjA-6ddeR:
8.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WLK_B_SPMB1302_1
(ATP-SENSITIVE INWARD
RECTIFIER POTASSIUM
CHANNEL 10)		 6dde SCFV16
(Mus
musculus) 		4 / 4 ALA E  49
TYR E  50
ALA E  61
TYR E  59
 None
 1.30A 2wlkA-6ddeE:
3.4
2wlkB-6ddeE:
3.1		 2wlkA-6ddeE:
15.02
2wlkB-6ddeE:
15.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		5 / 12 GLY R 253
VAL R 282
VAL R 286
ILE R 167
VAL R 163
 None
 0.96A 5n0sA-6ddeR:
undetectable		 5n0sA-6ddeR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0T_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		5 / 12 GLY R 253
VAL R 282
VAL R 286
ILE R 167
VAL R 163
 None
 0.94A 5n0tA-6ddeR:
undetectable		 5n0tA-6ddeR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0W_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		5 / 12 GLY R 253
VAL R 282
VAL R 286
ILE R 167
VAL R 163
 None
 0.92A 5n0wB-6ddeR:
undetectable		 5n0wB-6ddeR:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N4I_A_SAMA501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6dde MU-TYPE OPIOID
RECEPTOR
(Mus
musculus) 		5 / 12 GLY R 253
VAL R 282
VAL R 286
ILE R 167
VAL R 163
 None
 0.90A 5n4iA-6ddeR:
undetectable		 5n4iA-6ddeR:
undetectable