SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6de8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NHZ_A_486A800_1
(GLUCOCORTICOID
RECEPTOR)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 12 LEU A 128
ASN A 129
GLY A 131
MET A 145
LEU A 177
 None
 1.29A 1nhzA-6de8A:
undetectable		 1nhzA-6de8A:
14.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DZU_A_9CRA7223_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 12 ILE A 205
ALA A 160
ILE A 153
LEU A 177
VAL A 261
 None
 1.12A 3dzuA-6de8A:
undetectable		 3dzuA-6de8A:
11.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_C_SAMC300_0
(PUTATIVE RRNA
METHYLASE)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 12 THR A 265
ASN A 272
GLY A   6
LEU A 142
THR A 255
 None
 0.95A 3eeyC-6de8A:
4.1		 3eeyC-6de8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEY_E_SAME300_0
(PUTATIVE RRNA
METHYLASE)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 12 THR A 265
ASN A 272
GLY A   6
LEU A 142
THR A 255
 None
 0.99A 3eeyE-6de8A:
4.1		 3eeyE-6de8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSF_E_PZIE800_0
(GLUTAMATE RECEPTOR 2)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 10 PRO A 172
SER A 166
GLY A 170
PRO A 141
ASP A 227
 None
IOD  A 303 ( 4.8A)
None
None
None
 1.26A 3lsfB-6de8A:
undetectable
3lsfE-6de8A:
undetectable		 3lsfB-6de8A:
undetectable
3lsfE-6de8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_E_W9TE506_1
(HEMOLYTIC LECTIN
CEL-III)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		4 / 6 CYH A 139
THR A 140
GLY A 119
ASP A 118
 None
 1.24A 3w9tE-6de8A:
undetectable		 3w9tE-6de8A:
9.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A7A_B_RGZB601_1
(AMINE OXIDASE
[FLAVIN-CONTAINING]
B)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 12 LEU A  76
LEU A  79
LEU A  83
ILE A 111
ILE A  36
 None
 1.07A 4a7aB-6de8A:
undetectable		 4a7aB-6de8A:
9.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PO0_A_NPSA603_1
(SERUM ALBUMIN)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 10 LEU A 177
LEU A 203
VAL A 206
LEU A 214
VAL A 247
 None
 1.15A 4po0A-6de8A:
undetectable		 4po0A-6de8A:
10.34
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5I8F_A_ML1A211_1
(PHENOLIC OXIDATIVE
COUPLING PROTEIN)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		4 / 6 VAL A  48
LYS A  51
ALA A  52
VAL A  64
 None
None
IOD  A 309 ( 4.7A)
IOD  A 309 ( 4.9A)
 0.56A 5i8fA-6de8A:
undetectable		 5i8fA-6de8A:
17.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AG0_C_ACRC605_0
(ALPHA-AMYLASE)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		4 / 8 ILE A 107
ASP A 116
HIS A 121
PRO A 122
 None
 0.85A 6ag0C-6de8A:
undetectable		 6ag0C-6de8A:
19.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BKL_C_EU7C101_0
(MATRIX PROTEIN 2)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 9 ALA A 201
VAL A 225
VAL A 247
SER A 251
GLY A 222
 None
 1.03A 6bklA-6de8A:
undetectable
6bklB-6de8A:
undetectable
6bklC-6de8A:
undetectable
6bklD-6de8A:
undetectable		 6bklA-6de8A:
undetectable
6bklB-6de8A:
undetectable
6bklC-6de8A:
undetectable
6bklD-6de8A:
undetectable
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		12 / 12 LEU A  93
GLN A  95
LEU A  96
PRO A  97
LYS A 104
ASP A 118
PHE A 120
THR A 140
SER A 166
ILE A 168
VAL A 169
THR A 265
 None
None
IOD  A 304 ( 4.7A)
IOD  A 304 ( 4.8A)
IOD  A 303 (-4.1A)
None
None
None
IOD  A 303 ( 4.8A)
None
None
None
 0.37A 6debB-6de8A:
48.0		 6debB-6de8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB302_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		7 / 12 LEU A  93
GLN A  95
LEU A  96
PRO A  97
LYS A 104
ASP A 118
THR A 265
 None
None
IOD  A 304 ( 4.7A)
IOD  A 304 ( 4.8A)
IOD  A 303 (-4.1A)
None
None
 1.03A 6debB-6de8A:
48.0		 6debB-6de8A:
100.00
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
6DEB_B_MTXB303_1
(BIFUNCTIONAL PROTEIN
FOLD)		 6de8 BIFUNCTIONAL PROTEIN
FOLD
(Campylobacter
jejuni) 		5 / 5 TYR A  47
LYS A  51
GLN A  95
GLY A 209
ILE A 230
 None
 0.57A 6debB-6de8A:
48.0		 6debB-6de8A:
100.00