SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6deg'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1KQW_A_RTLA135_0
(CELLULAR
RETINOL-BINDING
PROTEIN)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 12 PHE A 345
ILE A 334
VAL A 277
LEU A 331
LEU A 297
 None
 1.30A 1kqwA-6degA:
undetectable		 1kqwA-6degA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 12 VAL A  53
VAL A 221
LEU A 212
LEU A 234
LEU A 137
 None
 0.97A 1mx1E-6degA:
undetectable		 1mx1E-6degA:
8.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 8 PHE A 131
VAL A 193
LEU A 172
PRO A 190
 None
 0.93A 3bgdB-6degA:
undetectable		 3bgdB-6degA:
15.77
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_I_ZPCI1318_1
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 7 PHE A  57
VAL A   5
ILE A  87
GLU A  55
 None
 1.14A 4a97H-6degA:
undetectable		 4a97H-6degA:
13.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EJJ_D_NCTD501_1
(CYTOCHROME P450 2A6)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 7 PHE A 345
GLY A 325
LEU A 297
PHE A 270
 None
 0.82A 4ejjD-6degA:
undetectable		 4ejjD-6degA:
9.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 9 THR A 177
GLY A 179
LEU A 182
VAL A 367
MET A 369
 None
 0.74A 4mjrA-6degA:
37.8		 4mjrA-6degA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MJR_A_0LAA404_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 9 THR A 177
LEU A 182
VAL A 254
VAL A 367
MET A 369
 None
 0.77A 4mjrA-6degA:
37.8		 4mjrA-6degA:
12.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ODO_A_FK5A205_2
(PEPTIDYL-PROLYL
CIS-TRANS ISOMERASE
SLYD)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 4 THR A   4
ARG A   2
GLU A  62
VAL A  88
 None
 1.04A 4odoC-6degA:
undetectable		 4odoC-6degA:
18.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 12 PHE A 345
ILE A 334
ALA A 354
VAL A 277
LEU A 331
 None
 1.31A 4qynA-6degA:
undetectable		 4qynA-6degA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_A_1FLA1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 8 THR A 177
LEU A 182
PRO A 353
MET A 369
 None
 0.75A 5g48A-6degA:
33.8		 5g48A-6degA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G48_B_1FLB1375_1
(DNA POLYMERASE III
SUBUNIT BETA)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 9 THR A 177
LEU A 182
PRO A 249
PRO A 353
MET A 369
 None
 0.97A 5g48B-6degA:
33.9		 5g48B-6degA:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IM2_A_BEZA401_0
(TWIN-ARGININE
TRANSLOCATION
PATHWAY SIGNAL)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 12 MET A 196
ILE A 223
LEU A 225
LEU A 243
VAL A 199
 None
 1.10A 5im2A-6degA:
undetectable		 5im2A-6degA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 6 PHE A  10
LEU A  81
SER A   8
GLY A  84
 None
 1.07A 5o4yF-6degA:
undetectable		 5o4yF-6degA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		5 / 12 LEU A 213
VAL A 206
LEU A 141
ILE A 223
LEU A 234
 None
 1.11A 5og9B-6degA:
undetectable		 5og9B-6degA:
9.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6EW0_F_TA1F502_2
(TUBULIN BETA CHAIN)		 6deg BETA SLIDING CLAMP
(Bartonella
birtlesii) 		4 / 5 LEU A 313
LEU A 263
THR A 291
PRO A 370
 None
 1.11A 6ew0F-6degA:
undetectable		 6ew0F-6degA:
25.84