SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dfp'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2IYF_A_ERYA1400_0
(OLEANDOMYCIN
GLYCOSYLTRANSFERASE)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 11 ASN A 248
VAL A 245
ILE A 228
ALA A 230
ASP A 255
 None
 1.34A 2iyfA-6dfpA:
undetectable		 2iyfA-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DL9_B_V2HB602_0
(CYTOCHROME P450 2R1)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 THR A  35
VAL A 155
ALA A 158
ALA A  57
ILE A 179
 None
 1.28A 3dl9B-6dfpA:
undetectable		 3dl9B-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EIG_A_MTXA200_2
(DIHYDROFOLATE
REDUCTASE)		 6dfp VCA0883
(Vibrio
cholerae) 		4 / 5 ASP A 340
ILE A  91
VAL A 330
THR A 301
 None
 1.19A 3eigA-6dfpA:
undetectable		 3eigA-6dfpA:
20.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HZN_G_ACTG225_0
(OXYGEN-INSENSITIVE
NAD(P)H
NITROREDUCTASE)		 6dfp VCA0883
(Vibrio
cholerae) 		3 / 3 PRO A 363
LEU A 361
GLN A 247
 None
 0.70A 3hznG-6dfpA:
undetectable
3hznH-6dfpA:
undetectable		 3hznG-6dfpA:
undetectable
3hznH-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IW1_A_ASDA1223_1
(CYTOCHROME P450
CYP125)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 ILE A 186
VAL A 284
GLN A  28
MET A 206
ILE A  65
 None
 1.19A 3iw1A-6dfpA:
undetectable		 3iw1A-6dfpA:
11.06
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QT0_A_486A4_2
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6dfp VCA0883
(Vibrio
cholerae) 		4 / 4 LYS A 191
GLN A  13
ILE A  76
LEU A 140
 None
 1.20A 3qt0A-6dfpA:
2.4		 3qt0A-6dfpA:
15.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G19_A_ACTA304_0
(GLUTATHIONE
TRANSFERASE GTE1)		 6dfp VCA0883
(Vibrio
cholerae) 		4 / 5 ALA A 185
ILE A 250
LEU A 246
ASN A 182
 None
 1.18A 4g19A-6dfpA:
undetectable		 4g19A-6dfpA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LTW_A_486A302_1
(ANCESTRAL STEROID
RECEPTOR 2)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 VAL A 211
ILE A 250
GLN A 249
ILE A 186
ALA A 185
 None
 1.06A 4ltwA-6dfpA:
3.3		 4ltwA-6dfpA:
13.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PD4_C_AOQC4003_1
(CYTOCHROME B)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 GLY A 227
VAL A 211
ILE A 186
MET A 175
ILE A 172
 None
 1.04A 4pd4C-6dfpA:
undetectable		 4pd4C-6dfpA:
9.84
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 10 THR A 214
SER A 225
ALA A 216
ALA A 218
THR A 220
 None
 1.18A 4qvwH-6dfpA:
undetectable
4qvwI-6dfpA:
undetectable		 4qvwH-6dfpA:
17.27
4qvwI-6dfpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVW_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 10 THR A 214
SER A 225
ALA A 216
ALA A 218
THR A 220
 None
 1.17A 4qvwV-6dfpA:
undetectable
4qvwW-6dfpA:
0.4		 4qvwV-6dfpA:
17.27
4qvwW-6dfpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QVY_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 THR A 214
SER A 225
ALA A 216
ALA A 218
THR A 220
 None
 1.22A 4qvyV-6dfpA:
undetectable
4qvyW-6dfpA:
undetectable		 4qvyV-6dfpA:
17.27
4qvyW-6dfpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_H_BO2H301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 THR A 214
SER A 225
ALA A 216
ALA A 218
THR A 220
 None
 1.18A 4qw1H-6dfpA:
undetectable
4qw1I-6dfpA:
undetectable		 4qw1H-6dfpA:
17.27
4qw1I-6dfpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_K_BO2K301_1
(PROTEASOME SUBUNIT
BETA TYPE-5
PROTEASOME SUBUNIT
BETA TYPE-6)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 11 THR A  23
ALA A 196
GLY A 232
ALA A 233
SER A 235
 None
 1.04A 4qw1K-6dfpA:
undetectable
4qw1L-6dfpA:
undetectable		 4qw1K-6dfpA:
20.41
4qw1L-6dfpA:
20.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QW1_V_BO2V301_1
(PROTEASOME SUBUNIT
BETA TYPE-2
PROTEASOME SUBUNIT
BETA TYPE-3)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 THR A 214
SER A 225
ALA A 216
ALA A 218
THR A 220
 None
 1.18A 4qw1V-6dfpA:
undetectable
4qw1W-6dfpA:
undetectable		 4qw1V-6dfpA:
17.27
4qw1W-6dfpA:
21.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 ASP A 152
ALA A  57
SER A  56
THR A  26
GLY A 144
 None
 1.22A 5m5cB-6dfpA:
undetectable		 5m5cB-6dfpA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_E_TA1E502_1
(TUBULIN BETA-2B
CHAIN)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 10 ASP A 152
ALA A  57
SER A  56
THR A  26
GLY A 144
 None
 1.20A 5m5cE-6dfpA:
undetectable		 5m5cE-6dfpA:
10.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVM_A_PFLA511_1
(PROTON-GATED ION
CHANNEL)		 6dfp VCA0883
(Vibrio
cholerae) 		4 / 8 ALA A  27
ILE A 354
ILE A 356
GLU A 357
 None
 0.69A 5mvmA-6dfpA:
3.9
5mvmB-6dfpA:
2.5		 5mvmA-6dfpA:
19.10
5mvmB-6dfpA:
19.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V1T_A_SAMA605_0
(RADICAL SAM)		 6dfp VCA0883
(Vibrio
cholerae) 		5 / 12 PHE A 305
LEU A 122
THR A  86
VAL A  80
THR A 301
 None
 1.47A 5v1tA-6dfpA:
undetectable		 5v1tA-6dfpA:
undetectable