SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dfu'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FK6_A_LNLA1201_1
(NON-SPECIFIC LIPID
TRANSFER PROTEIN)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 VAL A  94
LEU A  95
ASN A  96
ALA A 133
ALA A 317
 None
 0.99A 1fk6A-6dfuA:
undetectable		 1fk6A-6dfuA:
23.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S19_A_MC9A500_0
(VITAMIN D3 RECEPTOR)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 VAL A  29
ILE A  72
SER A   8
LEU A 209
LEU A  16
 None
 1.08A 1s19A-6dfuA:
undetectable		 1s19A-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QHF_A_ACTA507_0
(CHORISMATE SYNTHASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		3 / 3 LEU A 302
ASN A 297
ARG A 296
 None
 0.93A 2qhfA-6dfuA:
undetectable		 2qhfA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CS9_C_NILC600_2
(PROTO-ONCOGENE
TYROSINE-PROTEIN
KINASE ABL1)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 9 LEU A 138
TYR A 139
VAL A  42
VAL A  10
PHE A   7
 None
None
TRP  A 501 ( 4.6A)
None
TRP  A 501 (-4.9A)
 1.21A 3cs9C-6dfuA:
undetectable		 3cs9C-6dfuA:
15.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.78A 3fhjA-6dfuA:
40.2		 3fhjA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 10 GLY A   9
GLN A  11
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.88A 3fhjB-6dfuA:
38.2		 3fhjB-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 10 GLY A   9
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.56A 3fhjB-6dfuA:
38.2		 3fhjB-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.76A 3fhjC-6dfuA:
37.3		 3fhjC-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.56A 3fhjD-6dfuA:
39.1		 3fhjD-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		10 / 10 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.71A 3fhjE-6dfuA:
39.1		 3fhjE-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FHJ_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.56A 3fhjF-6dfuA:
39.7		 3fhjF-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.86A 3fi0A-6dfuA:
38.9		 3fi0A-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_A_TRPA1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
 1.09A 3fi0A-6dfuA:
38.9		 3fi0A-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_B_TRPB1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 8 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.55A 3fi0B-6dfuA:
38.5		 3fi0B-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_C_TRPC1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.86A 3fi0C-6dfuA:
39.2		 3fi0C-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		6 / 9 GLY A   9
GLN A  11
VAL A  42
ASP A 135
ILE A 136
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-3.9A)
None
None
 0.67A 3fi0D-6dfuA:
40.1		 3fi0D-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_D_TRPD1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.60A 3fi0D-6dfuA:
40.1		 3fi0D-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 7 GLY A   9
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
TRP  A 501 (-3.3A)
 0.61A 3fi0E-6dfuA:
38.1		 3fi0E-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_E_TRPE1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		6 / 7 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
 0.23A 3fi0E-6dfuA:
38.1		 3fi0E-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		7 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
 0.70A 3fi0F-6dfuA:
31.1		 3fi0F-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_F_TRPF1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.61A 3fi0F-6dfuA:
31.1		 3fi0F-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_G_TRPG1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 8 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.62A 3fi0G-6dfuA:
40.1		 3fi0G-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
 0.67A 3fi0H-6dfuA:
39.9		 3fi0H-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_H_TRPH1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
TRP  A 501 (-3.3A)
 0.89A 3fi0H-6dfuA:
39.9		 3fi0H-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		7 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
 0.67A 3fi0J-6dfuA:
39.9		 3fi0J-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_J_TRPJ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.65A 3fi0J-6dfuA:
39.9		 3fi0J-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_K_TRPK1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.88A 3fi0K-6dfuA:
38.7		 3fi0K-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_L_TRPL1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.83A 3fi0L-6dfuA:
39.9		 3fi0L-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
 0.72A 3fi0M-6dfuA:
39.5		 3fi0M-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_M_TRPM1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.62A 3fi0M-6dfuA:
39.5		 3fi0M-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_N_TRPN1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.87A 3fi0N-6dfuA:
39.7		 3fi0N-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_O_TRPO1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.82A 3fi0O-6dfuA:
39.6		 3fi0O-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_P_TRPP1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		7 / 7 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
TRP  A 501 (-3.3A)
 0.76A 3fi0P-6dfuA:
38.6		 3fi0P-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_Q_TRPQ1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 8 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
 0.74A 3fi0Q-6dfuA:
39.8		 3fi0Q-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		7 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
 0.59A 3fi0R-6dfuA:
37.2		 3fi0R-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		8 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
ILE A 136
VAL A 144
VAL A 146
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
None
None
TRP  A 501 (-3.3A)
 0.59A 3fi0R-6dfuA:
37.2		 3fi0R-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FI0_R_TRPR1001_0
(TRYPTOPHANYL-TRNA
SYNTHETASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
ASP A 135
VAL A 144
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.9A)
None
 1.05A 3fi0R-6dfuA:
37.2		 3fi0R-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3QXV_D_MTXD2000_2
(ANTI-METHOTREXATE
CDR1-4 GRAFT VHH)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		3 / 3 LEU A  64
ARG A 307
ASN A  75
 None
 0.77A 3qxvD-6dfuA:
undetectable		 3qxvD-6dfuA:
19.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UQ6_B_ADNB401_1
(ADENOSINE KINASE,
PUTATIVE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 ASN A  20
GLY A  23
ALA A  24
ASN A  27
GLY A 180
 None
 1.06A 3uq6B-6dfuA:
undetectable		 3uq6B-6dfuA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VAQ_B_ADNB401_1
(PUTATIVE ADENOSINE
KINASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 ASN A  20
GLY A  23
ALA A  24
ASN A  27
GLY A 180
 None
 1.09A 3vaqB-6dfuA:
undetectable		 3vaqB-6dfuA:
12.05
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EB6_C_VLBC503_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA CHAIN)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 VAL A  10
THR A  78
TYR A  67
ILE A 136
VAL A 144
 None
 1.16A 4eb6B-6dfuA:
undetectable
4eb6C-6dfuA:
undetectable		 4eb6B-6dfuA:
10.99
4eb6C-6dfuA:
11.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ECK_A_FOLA703_0
(BIFUNCTIONAL
DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 ALA A 133
LEU A 131
PHE A   7
SER A   8
THR A 157
 None
None
TRP  A 501 (-4.9A)
None
None
 1.26A 4eckA-6dfuA:
undetectable		 4eckA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F3T_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		4 / 6 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.76A 4f3tA-6dfuA:
undetectable		 4f3tA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KIC_B_SAMB401_0
(METHYLTRANSFERASE
MPPJ)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 12 GLY A  19
GLY A  23
ILE A 249
ALA A 252
MET A 196
 None
 1.10A 4kicB-6dfuA:
undetectable		 4kicB-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4F_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		4 / 7 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.68A 4z4fA-6dfuA:
undetectable		 4z4fA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE2_A_1YNA602_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		4 / 5 ALA A 322
TYR A 325
HIS A  45
PRO A  86
 None
None
TRP  A 501 (-4.0A)
None
 1.28A 4ze2A-6dfuA:
undetectable		 4ze2A-6dfuA:
10.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KI6_A_IPHA901_0
(PROTEIN ARGONAUTE-2)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		4 / 5 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.73A 5ki6A-6dfuA:
undetectable		 5ki6A-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5T7B_A_IPHA902_0
(PROTEIN ARGONAUTE-2)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		4 / 7 LEU A  16
TYR A  21
LEU A  66
TYR A  67
 None
 0.75A 5t7bA-6dfuA:
undetectable		 5t7bA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
TRP  A 501 (-3.3A)
 0.61A 5v0iA-6dfuA:
45.7		 5v0iA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_A_TRPA402_0
(TRYPTOPHAN--TRNA
LIGASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
None
 1.33A 5v0iA-6dfuA:
45.7		 5v0iA-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		9 / 9 GLY A   9
GLN A  11
VAL A  42
HIS A  45
MET A 132
ASP A 135
ILE A 136
VAL A 144
GLN A 150
 TRP  A 501 (-3.5A)
TRP  A 501 (-4.2A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
TRP  A 501 (-3.9A)
None
None
TRP  A 501 (-3.3A)
 0.61A 5v0iB-6dfuA:
44.7		 5v0iB-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5V0I_B_TRPB402_0
(TRYPTOPHAN--TRNA
LIGASE)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		5 / 9 GLY A   9
VAL A  42
HIS A  45
MET A 132
VAL A 146
 TRP  A 501 (-3.5A)
TRP  A 501 ( 4.6A)
TRP  A 501 (-4.0A)
TRP  A 501 (-3.5A)
None
 1.36A 5v0iB-6dfuA:
44.7		 5v0iB-6dfuA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6AZ3_1_PAR11803_1
(RRNA ALPHA
RIBOSOMAL PROTEIN
EL18)		 6dfu TRYPTOPHAN--TRNA
LIGASE
(Haemophilus
influenzae) 		3 / 3 SER A 199
LYS A 198
SER A 197
 None
 0.79A 6az3P-6dfuA:
undetectable		 6az3P-6dfuA:
23.16