SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dfz'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 7 ASN A 315
TYR A 319
ASN A 154
TYR A 313
 NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
None
None
 0.97A 1dssG-6dfzA:
54.4		 1dssG-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_G_CCSG149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		7 / 7 SER A 150
THR A 152
ASN A 154
CYH A 155
TYR A 313
ASN A 315
TYR A 319
 PO4  A 402 (-2.7A)
PO4  A 402 (-3.1A)
None
None
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
 0.14A 1dssG-6dfzA:
54.4		 1dssG-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 8 ASN A 315
TYR A 319
ASN A 154
TYR A 313
 NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
None
None
 0.96A 1dssR-6dfzA:
54.4		 1dssR-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DSS_R_CCSR149_0
(D-GLYCERALDEHYDE-3-P
HOSPHATE-DEHYDROGENA
SE)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		8 / 8 SER A 150
THR A 152
ASN A 154
CYH A 155
HIS A 178
TYR A 313
ASN A 315
TYR A 319
 PO4  A 402 (-2.7A)
PO4  A 402 (-3.1A)
None
None
PO4  A 402 (-4.0A)
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
 0.21A 1dssR-6dfzA:
54.4		 1dssR-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WRL_E_TFPE212_1
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 7 PHE A  45
PHE A   9
MET A  17
SER A  20
 None
 1.18A 1wrlE-6dfzA:
undetectable		 1wrlE-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HCJ_B_TACB888_1
(PROTEIN CHAIN
ELONGATION FACTOR
EF-TU)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 4 THR A 103
SER A 123
ASP A 125
PRO A 127
 None
 1.50A 2hcjA-6dfzA:
0.0
2hcjB-6dfzA:
0.4		 2hcjA-6dfzA:
undetectable
2hcjB-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YFB_A_ACTA501_0
(METHYL-ACCEPTING
CHEMOTAXIS
TRANSDUCER)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 7 MET A 330
VAL A 146
ILE A 118
TYR A 138
 None
 0.98A 2yfbA-6dfzA:
undetectable		 2yfbA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 8 ASN A 315
TYR A 319
ASN A 154
TYR A 313
 NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
None
None
 0.99A 3dmtC-6dfzA:
27.4		 3dmtC-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DMT_C_CCSC166_0
(GLYCERALDEHYDE-3-PHO
SPHATE
DEHYDROGENASE,
GLYCOSOMAL)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		8 / 8 SER A 150
THR A 152
ASN A 154
CYH A 155
HIS A 178
TYR A 313
ASN A 315
TYR A 319
 PO4  A 402 (-2.7A)
PO4  A 402 (-3.1A)
None
None
PO4  A 402 (-4.0A)
None
NAD  A 401 (-4.0A)
NAD  A 401 (-3.6A)
 0.23A 3dmtC-6dfzA:
27.4		 3dmtC-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 6 THR A  97
ASN A   7
ASP A  33
ILE A  36
 NAD  A 401 (-4.1A)
NAD  A 401 (-3.7A)
NAD  A 401 (-3.0A)
None
 1.44A 3w9tB-6dfzA:
undetectable		 3w9tB-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4A97_A_ZPCA1318_2
(CYS-LOOP
LIGAND-GATED ION
CHANNEL)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		4 / 7 VAL A 162
ILE A 163
ASN A 166
GLU A 266
 None
 1.00A 4a97E-6dfzA:
undetectable		 4a97E-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1G_A_LNLA701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		5 / 12 TYR A 313
ASN A 224
GLY A 211
ALA A 212
GLY A 217
 None
None
PO4  A 402 (-3.6A)
None
None
 0.99A 4e1gA-6dfzA:
undetectable		 4e1gA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNW_A_T3A501_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		3 / 3 ILE A 118
MET A 131
ARG A 322
 None
 0.88A 4lnwA-6dfzA:
undetectable		 4lnwA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LNX_A_T3A502_2
(THYROID HORMONE
RECEPTOR ALPHA)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		3 / 3 ILE A 118
MET A 131
ARG A 322
 None
 0.88A 4lnxA-6dfzA:
undetectable		 4lnxA-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		5 / 9 THR A 153
LEU A 227
GLY A 217
VAL A 133
VAL A 130
 None
 1.42A 5cp4A-6dfzA:
undetectable		 5cp4A-6dfzA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ERS_A_ACTA803_0
(GEPHYRIN)		 6dfz GLYCERALDEHYDE-3-PHO
SPHATE DEHYDROGENASE
(Acropora
millepora) 		3 / 3 THR A 153
ALA A 149
ASN A 154
 None
 0.63A 5ersA-6dfzA:
3.8		 5ersA-6dfzA:
undetectable