SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dg4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H4O_A_BEZA1162_0
(PEROXIREDOXIN 5)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 10 GLY A 243
LEU A  44
PHE A  49
THR A  38
GLY A  67
 None
 1.38A 1h4oA-6dg4A:
undetectable
1h4oB-6dg4A:
undetectable		 1h4oA-6dg4A:
undetectable
1h4oB-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P6K_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 8 SER A   2
GLN A 192
PHE A 191
ASP A 218
 None
 1.31A 1p6kA-6dg4A:
undetectable		 1p6kA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZQ_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 8 SER A   2
GLN A 192
PHE A 191
ASP A 218
 None
 1.29A 1zzqA-6dg4A:
undetectable		 1zzqA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ZZU_A_MTLA870_0
(NITRIC-OXIDE
SYNTHASE, BRAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 8 SER A   2
GLN A 192
PHE A 191
ASP A 218
 None
 1.28A 1zzuA-6dg4A:
undetectable		 1zzuA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_F_SAMF301_0
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 GLY A 216
LEU A 215
ALA A  73
ALA A  91
ASP A 126
 None
 0.98A 2bm9F-6dg4A:
undetectable		 2bm9F-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QEU_B_ACTB141_0
(PUTATIVE
CARBOXYMUCONOLACTONE
DECARBOXYLASE)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		3 / 3 PRO A  87
ASN A 116
ARG A 118
 None
 0.96A 2qeuB-6dg4A:
undetectable		 2qeuB-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGN_A_PCFA1179_1
(WNT INHIBITORY
FACTOR 1)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 5 PHE A 122
PRO A 105
VAL A  76
PHE A  92
 None
 1.12A 2ygnA-6dg4A:
undetectable		 2ygnA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CYX_A_ROCA201_1
(HIV-1 PROTEASE)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 LEU A  53
GLY A  67
ALA A  68
GLY A 243
ILE A 235
 None
 1.04A 3cyxA-6dg4A:
undetectable		 3cyxA-6dg4A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EAT_B_BEZB1000_0
(BENZOATE-COENZYME A
LIGASE)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 9 ALA A 236
ALA A  68
GLY A  67
ILE A  65
ILE A 207
 None
 1.05A 4eatB-6dg4A:
undetectable		 4eatB-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FP9_D_SAMD401_1
(METHYLTRANSFERASE
NSUN4)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		3 / 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.77A 4fp9D-6dg4A:
undetectable		 4fp9D-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FZV_A_SAMA401_1
(PUTATIVE
METHYLTRANSFERASE
NSUN4)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		3 / 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.59A 4fzvA-6dg4A:
undetectable		 4fzvA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_B_ESTB600_1
(ESTROGEN RECEPTOR
BETA)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 LEU A 100
LEU A 101
GLU A 134
ARG A 164
ILE A 143
 None
 1.22A 4j24B-6dg4A:
undetectable		 4j24B-6dg4A:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NC3_A_ERMA1202_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 6 LEU A  39
GLN A  42
LEU A  44
GLU A  34
 None
 0.87A 4nc3A-6dg4A:
undetectable		 4nc3A-6dg4A:
12.78
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O2B_B_LOCB503_2
(TUBULIN BETA-2B
CHAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.82A 4o2bB-6dg4A:
undetectable		 4o2bB-6dg4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_S_BEZS801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 6 PHE A  96
SER A 102
HIS A 103
LEU A 111
 None
 1.32A 5dzke-6dg4A:
undetectable
5dzks-6dg4A:
undetectable		 5dzke-6dg4A:
undetectable
5dzks-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EYP_B_LOCB502_2
(TUBULIN BETA CHAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.87A 5eypB-6dg4A:
undetectable		 5eypB-6dg4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HES_A_032A401_2
(MITOGEN-ACTIVATED
PROTEIN KINASE
KINASE KINASE MLT)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		4 / 6 LYS A 119
PHE A 175
VAL A 182
ASP A 179
 None
 1.22A 5hesA-6dg4A:
undetectable		 5hesA-6dg4A:
14.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MIO_B_LOCB502_1
(TUBULIN BETA CHAIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		5 / 12 ALA A 167
THR A 139
ALA A 141
ILE A 143
ILE A 130
 None
 0.81A 5mioB-6dg4A:
undetectable		 5mioB-6dg4A:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_A_SAMA401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		3 / 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.61A 5zvgA-6dg4A:
undetectable		 5zvgA-6dg4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ZVG_B_SAMB401_1
(389AA LONG
HYPOTHETICAL
NUCLEOLAR PROTEIN)		 6dg4 ULP1-LIKE SUMO
PROTEASE
(Chaetomium
thermophilum) 		3 / 3 ASP A  48
ARG A  47
ASP A  62
 None
GOL  A 303 (-2.6A)
None
 0.63A 5zvgB-6dg4A:
undetectable		 5zvgB-6dg4A:
undetectable