SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dgc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 7 TYR A  98
VAL A 133
TYR A  92
ILE A  69
 None
 1.11A 2xz5B-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable		 2xz5B-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_C_ACHC1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 8 ILE A  69
TYR A  98
VAL A 133
TYR A  92
 None
 1.08A 2xz5A-6dgcA:
undetectable
2xz5C-6dgcA:
undetectable		 2xz5A-6dgcA:
undetectable
2xz5C-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_D_ACHD1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 8 ILE A  69
TYR A  98
VAL A 133
TYR A  92
 None
 1.08A 2xz5C-6dgcA:
undetectable
2xz5D-6dgcA:
undetectable		 2xz5C-6dgcA:
undetectable
2xz5D-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1210_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 7 ILE A  69
TYR A  98
VAL A 133
TYR A  92
 None
 1.08A 2xz5D-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable		 2xz5D-6dgcA:
undetectable
2xz5E-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PS9_A_SAMA670_1
(TRNA
5-METHYLAMINOMETHYL-
2-THIOURIDINE
BIOSYNTHESIS
BIFUNCTIONAL PROTEIN
MNMC)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 6 GLY A 110
THR A 142
LEU A 141
ASP A 106
 None
 1.00A 3ps9A-6dgcA:
2.7		 3ps9A-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA504_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 8 GLY A 145
ILE A 149
THR A 113
THR A 142
 None
 0.65A 4em2A-6dgcA:
undetectable		 4em2A-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		4 / 8 LEU A 119
ILE A 149
PHE A 144
LEU A 111
 None
 0.86A 5y7pC-6dgcA:
undetectable		 5y7pC-6dgcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6BXL_A_SAMA401_0
(2-(3-AMINO-3-CARBOXY
PROPYL)HISTIDINE
SYNTHASE)		 6dgc ISC1926 TNPA
C-TERMINAL CATALYTIC
DOMAIN
(Sulfolobus
sp.
L00
11) 		5 / 12 LEU A 111
GLY A 110
ASP A  77
VAL A  73
ASP A 106
 None
 1.21A 6bxlA-6dgcA:
3.1		 6bxlA-6dgcA:
undetectable