SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dgi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ERR_A_CCSA381_0
(ESTROGEN RECEPTOR)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 HIS A 276
GLU A 211
ALA A 209
HIS A 316
 None
 1.16A 1errA-6dgiA:
undetectable
1errB-6dgiA:
undetectable		 1errA-6dgiA:
undetectable
1errB-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHO_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 9 THR A  89
GLY A  87
PHE A  85
SER A  14
GLY A 166
 None
None
None
None
ACT  A 402 (-4.3A)
 1.32A 1jhoA-6dgiA:
1.9		 1jhoA-6dgiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JHY_A_NIOA991_1
(NICOTINATE
MONONUCLEOTIDE:5,6-D
IMETHYLBENZIMIDAZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 9 THR A  89
GLY A  87
PHE A  85
SER A  14
GLY A 166
 None
None
None
None
ACT  A 402 (-4.3A)
 1.35A 1jhyA-6dgiA:
undetectable		 1jhyA-6dgiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1L5L_A_NIOA991_1
(NICOTINATE-NUCLEOTID
E--DIMETHYLBENZIMIDA
ZOLE
PHOSPHORIBOSYLTRANSF
ERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 9 THR A  89
GLY A  87
PHE A  85
SER A  14
GLY A 166
 None
None
None
None
ACT  A 402 (-4.3A)
 1.31A 1l5lA-6dgiA:
1.9		 1l5lA-6dgiA:
13.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 PRO A  86
PHE A  85
GLY A 166
SER A 167
VAL A 169
 None
None
ACT  A 402 (-4.3A)
None
None
 1.21A 1nw5A-6dgiA:
undetectable		 1nw5A-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CL5_B_SAMB1217_1
(CATECHOL
O-METHYLTRANSFERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 6 SER A  23
GLU A  88
SER A 167
GLN A 165
 None
ACT  A 402 (-2.6A)
None
None
 1.39A 2cl5B-6dgiA:
undetectable		 2cl5B-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QWX_B_ML1B233_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 7 GLY A 300
GLY A 105
PHE A 321
PHE A 318
 None
 0.97A 2qwxA-6dgiA:
2.8
2qwxB-6dgiA:
undetectable		 2qwxA-6dgiA:
16.09
2qwxB-6dgiA:
16.09
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZVJ_A_SAMA301_1
(CATECHOL
O-METHYLTRANSFERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 6 SER A  23
GLU A  88
SER A 167
GLN A 165
 None
ACT  A 402 (-2.6A)
None
None
 1.39A 2zvjA-6dgiA:
undetectable		 2zvjA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UWL_D_FOZD316_0
(THYMIDYLATE SYNTHASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 LEU A 311
GLY A 300
PHE A 307
ILE A  27
ALA A  24
 None
 1.06A 3uwlD-6dgiA:
undetectable		 3uwlD-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OLB_A_TRPA902_0
(PROTEIN ARGONAUTE-2)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 TYR A 124
LYS A 121
GLU A 197
TYR A 134
 None
 1.34A 4olbA-6dgiA:
3.5		 4olbA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QWP_A_GCSA301_1
(CHITOSANASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		3 / 3 TYR A 103
GLY A 107
PRO A 108
 None
None
GOL  A 401 (-4.6A)
 0.71A 4qwpA-6dgiA:
undetectable		 4qwpA-6dgiA:
18.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNV_A_QI9A602_0
(CYTOCHROME P450 2D6)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 9 SER A 143
VAL A 196
VAL A 194
PHE A 136
LEU A 135
 None
 1.15A 4wnvA-6dgiA:
undetectable		 4wnvA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XT7_A_TOPA302_1
(RV2671)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 11 ASN A 293
THR A 119
SER A 120
GLU A 294
THR A 132
 None
None
None
ACT  A 402 ( 4.0A)
None
 1.35A 4xt7A-6dgiA:
undetectable		 4xt7A-6dgiA:
13.93
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DQY_A_BEZA401_0
(THIOREDOXIN)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 8 ILE A 158
LYS A 149
PHE A 152
GLU A 177
 None
 1.11A 5dqyA-6dgiA:
1.6		 5dqyA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHR_B_SAMB303_1
(CATECHOL
O-METHYLTRANSFERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 SER A  23
GLU A  88
SER A 167
GLN A 165
 None
ACT  A 402 (-2.6A)
None
None
 1.37A 5fhrB-6dgiA:
undetectable		 5fhrB-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GWX_A_SAMA301_0
(GLYCINE SARCOSINE
N-METHYLTRANSFERASE)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 ALA A 162
GLY A 170
GLY A 166
SER A 167
GLY A 189
 None
None
ACT  A 402 (-4.3A)
None
None
 1.01A 5gwxA-6dgiA:
undetectable		 5gwxA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5H5F_A_SAMA301_1
(PROTEIN ARGININE
N-METHYLTRANSFERASE
SFM1)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 GLY A  84
PRO A 108
THR A  89
GLN A  93
 ACT  A 402 ( 4.1A)
GOL  A 401 (-4.6A)
None
None
 1.24A 5h5fA-6dgiA:
undetectable		 5h5fA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IY5_P_CHDP307_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 ARG A 203
LEU A 205
PHE A 282
LEU A 253
 None
 1.23A 5iy5P-6dgiA:
undetectable
5iy5W-6dgiA:
undetectable		 5iy5P-6dgiA:
undetectable
5iy5W-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 LEU A  96
TRP A  49
PRO A 108
SER A 111
GLY A  90
 None
None
GOL  A 401 (-4.6A)
None
GOL  A 401 (-4.6A)
 1.21A 5nnaA-6dgiA:
undetectable		 5nnaA-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 LEU A  96
TRP A  49
PRO A 108
SER A 111
GLY A  90
 None
None
GOL  A 401 (-4.6A)
None
GOL  A 401 (-4.6A)
 1.19A 5nnaB-6dgiA:
undetectable		 5nnaB-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		5 / 12 LEU A  96
TRP A  49
PRO A 108
SER A 111
GLY A  90
 None
None
GOL  A 401 (-4.6A)
None
GOL  A 401 (-4.6A)
 1.17A 5nnaC-6dgiA:
undetectable		 5nnaC-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O4Y_F_CCSF14_0
(PHE-MAA-ASN-PRO-HIS-
LEU-SER-TRP-SER-TRP-
9KK-9KK-ARG-CCS-GLY-
NH2)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 6 PHE A 298
LEU A   9
SER A  20
GLY A  11
 None
 1.11A 5o4yF-6dgiA:
undetectable		 5o4yF-6dgiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XDX_C_CHDC308_0
(CYTOCHROME C OXIDASE
SUBUNIT 3
CYTOCHROME C OXIDASE
SUBUNIT VIIA-HEART)		 6dgi D-ALANINE--D-ALANINE
LIGASE
(Vibrio
cholerae) 		4 / 5 ARG A 203
LEU A 205
PHE A 282
LEU A 253
 None
 1.27A 5xdxC-6dgiA:
undetectable
5xdxJ-6dgiA:
undetectable		 5xdxC-6dgiA:
undetectable
5xdxJ-6dgiA:
undetectable