SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dhi'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_B_DVAB8_0
(GRAMICIDIN A)		 6dhi -
(-) 		3 / 3 VAL A 158
VAL A  49
TRP A  47
 None
 0.73A 1av2A-6dhiA:
undetectable
1av2B-6dhiA:
undetectable		 1av2A-6dhiA:
undetectable
1av2B-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1NW5_A_SAMA401_0
(MODIFICATION
METHYLASE RSRI)		 6dhi -
(-) 		5 / 12 ASP A 415
PRO A 411
THR A 231
GLY A 169
ALA A 445
 None
 1.28A 1nw5A-6dhiA:
undetectable		 1nw5A-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2I30_A_SALA1100_1
(SERUM ALBUMIN)		 6dhi -
(-) 		4 / 6 HIS A 165
TYR A 350
GLY A  56
LYS A  55
 SNN  A 164 ( 3.8A)
None
None
None
 1.45A 2i30A-6dhiA:
undetectable		 2i30A-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y7K_D_SALD1300_1
(LYSR-TYPE REGULATORY
PROTEIN)		 6dhi -
(-) 		5 / 12 ILE A 388
GLY A 389
PHE A 393
LEU A 422
ILE A 452
 None
 1.22A 2y7kD-6dhiA:
undetectable		 2y7kD-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_2
(PHOSPHOLIPASE A2)		 6dhi -
(-) 		4 / 5 VAL A 300
VAL A 299
GLN A 278
PHE A 202
 None
 1.40A 3bjwB-6dhiA:
undetectable		 3bjwB-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O1E_A_C2FA3000_1
(DIHYDROPTEROATE
SYNTHASE DHPS)		 6dhi -
(-) 		3 / 3 LYS A 118
ASN A 129
ASP A  89
 None
 0.68A 4o1eA-6dhiA:
undetectable		 4o1eA-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA0_A_SHHA404_1
(HISTONE DEACETYLASE
8)		 6dhi -
(-) 		5 / 12 TYR A 350
ASP A  65
HIS A  62
ASP A 257
GLY A 256
 None
None
SNN  A 164 ( 3.2A)
None
None
 1.29A 4qa0A-6dhiA:
undetectable		 4qa0A-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QA2_B_SHHB404_1
(HISTONE DEACETYLASE
8)		 6dhi -
(-) 		5 / 12 TYR A 350
ASP A  65
HIS A  62
ASP A 257
GLY A 256
 None
None
SNN  A 164 ( 3.2A)
None
None
 1.29A 4qa2B-6dhiA:
2.1		 4qa2B-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGV_A_ZITA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6dhi -
(-) 		5 / 12 GLY A 210
GLU A 435
ALA A 445
ILE A 179
TYR A 162
 None
None
None
None
SNN  A 164 ( 4.6A)
 1.21A 5igvA-6dhiA:
undetectable		 5igvA-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_E_ASCE1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6dhi -
(-) 		4 / 7 HIS A 157
ILE A 200
VAL A 201
GLN A 310
 None
 1.13A 5kkzC-6dhiA:
undetectable
5kkzE-6dhiA:
undetectable		 5kkzC-6dhiA:
undetectable
5kkzE-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_K_ASCK1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6dhi -
(-) 		4 / 7 HIS A 157
ILE A 200
VAL A 201
GLN A 310
 None
 1.17A 5kkzK-6dhiA:
undetectable
5kkzQ-6dhiA:
undetectable		 5kkzK-6dhiA:
undetectable
5kkzQ-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KKZ_O_ASCO1004_0
(CYTOCHROME B
UBIQUINOL-CYTOCHROME
C REDUCTASE
IRON-SULFUR SUBUNIT)		 6dhi -
(-) 		4 / 7 HIS A 157
ILE A 200
VAL A 201
GLN A 310
 None
 1.07A 5kkzM-6dhiA:
undetectable
5kkzO-6dhiA:
undetectable		 5kkzM-6dhiA:
undetectable
5kkzO-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MVS_A_ADNA401_1
(HISTONE-LYSINE
N-METHYLTRANSFERASE,
H3 LYSINE-79
SPECIFIC)		 6dhi -
(-) 		4 / 7 GLY A 232
GLU A 208
ALA A 168
ASP A 214
 None
 0.89A 5mvsA-6dhiA:
3.0		 5mvsA-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1801_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6dhi -
(-) 		4 / 9 ILE A 179
TYR A 162
ILE A 160
ILE A 200
 None
SNN  A 164 ( 4.6A)
None
None
 0.70A 5vkqB-6dhiA:
undetectable
5vkqC-6dhiA:
undetectable		 5vkqB-6dhiA:
undetectable
5vkqC-6dhiA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VOO_F_C2FF3001_0
(5-METHYLTETRAHYDROFO
LATE HOMOCYSTEINE
S-METHYLTRANSFERASE)		 6dhi -
(-) 		5 / 12 GLY A 167
LYS A 439
VAL A 187
LEU A 188
ILE A 179
 None
 1.19A 5vooF-6dhiA:
undetectable		 5vooF-6dhiA:
undetectable