SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dk2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_B_HLTB4002_1
(SERUM ALBUMIN)		 6dk2 -
(-) 		4 / 4 ARG A 216
ALA A 501
ALA A 483
GLU A 493
 None
 1.07A 1e7bB-6dk2A:
undetectable		 1e7bB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7W_A_MTXA301_1
(PTERIDINE REDUCTASE)		 6dk2 -
(-) 		5 / 12 PHE A 488
PRO A 491
LEU A  70
TYR A  64
LEU A 397
 None
 1.16A 1e7wA-6dk2A:
undetectable		 1e7wA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EKJ_G_ACTG3009_0
(BETA-CARBONIC
ANHYDRASE)		 6dk2 -
(-) 		4 / 5 LEU A 105
THR A 106
ARG A 129
VAL A 132
 None
 1.10A 1ekjF-6dk2A:
undetectable
1ekjG-6dk2A:
undetectable		 1ekjF-6dk2A:
undetectable
1ekjG-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HWI_B_115B1_1
(HMG-COA REDUCTASE)		 6dk2 -
(-) 		5 / 9 CYH A 412
HIS A 487
LEU A 486
ALA A 439
LEU A 442
 None
None
None
None
EDO  A 615 ( 4.3A)
 1.41A 1hwiA-6dk2A:
undetectable		 1hwiA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OG5_B_SWFB502_1
(CYTOCHROME P450 2C9)		 6dk2 -
(-) 		6 / 12 ILE A 127
PHE A 128
LEU A 125
ALA A 124
PHE A 182
LEU A 405
 None
 1.50A 1og5B-6dk2A:
1.0		 1og5B-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P33_D_MTXD354_1
(PTERIDINE REDUCTASE
1)		 6dk2 -
(-) 		5 / 12 PHE A 488
PRO A 491
LEU A  70
TYR A  64
LEU A 397
 None
 1.19A 1p33D-6dk2A:
undetectable		 1p33D-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_A_ESTA600_1
(ESTRADIOL RECEPTOR)		 6dk2 -
(-) 		5 / 10 ALA A 492
GLU A 493
ARG A 216
ILE A 143
LEU A  97
 None
 1.36A 1qkuA-6dk2A:
undetectable		 1qkuA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_B_ESTB600_1
(ESTRADIOL RECEPTOR)		 6dk2 -
(-) 		5 / 10 ALA A 492
GLU A 493
ARG A 216
ILE A 143
LEU A  97
 None
 1.36A 1qkuB-6dk2A:
undetectable		 1qkuB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKU_C_ESTC600_1
(ESTRADIOL RECEPTOR)		 6dk2 -
(-) 		5 / 10 ALA A 492
GLU A 493
ARG A 216
ILE A 143
LEU A  97
 None
 1.36A 1qkuC-6dk2A:
undetectable		 1qkuC-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SKX_A_RFPA1_1
(ORPHAN NUCLEAR
RECEPTOR PXR)		 6dk2 -
(-) 		5 / 12 LEU A 293
PHE A 273
HIS A 489
ILE A 485
PHE A 289
 None
 1.17A 1skxA-6dk2A:
undetectable		 1skxA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TKQ_A_DVAA6_0
(MINI-GRAMICIDIN A)		 6dk2 -
(-) 		3 / 3 ALA A 496
VAL A 498
TRP A 484
 None
 1.02A 1tkqA-6dk2A:
undetectable		 1tkqA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DPZ_A_TYLA2001_1
(PHOSPHOLIPASE A2
VRV-PL-VIIIA)		 6dk2 -
(-) 		4 / 6 LEU A 135
ALA A 496
HIS A  59
TYR A  55
 None
 1.31A 2dpzA-6dk2A:
undetectable		 2dpzA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PNC_A_CLUA808_1
(COPPER AMINE
OXIDASE, LIVER
ISOZYME)		 6dk2 -
(-) 		4 / 7 ALA A 492
TYR A 139
TYR A  50
HIS A  59
 None
 0.99A 2pncA-6dk2A:
undetectable		 2pncA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RCT_A_RTLA140_0
(RETINOL-BINDING
PROTEIN II, CELLULAR)		 6dk2 -
(-) 		5 / 12 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.23A 2rctA-6dk2A:
undetectable		 2rctA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2WEK_B_DIFB1376_1
(ZINC-BINDING ALCOHOL
DEHYDROGENASE
DOMAIN-CONTAINING
PROTEIN 2)		 6dk2 -
(-) 		4 / 7 GLY A 100
ALA A 101
MET A 102
LEU A 105
 None
 0.71A 2wekB-6dk2A:
undetectable		 2wekB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_B_ACHB1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dk2 -
(-) 		4 / 8 TYR A 549
TYR A 527
GLN A 540
ILE A 529
 None
 1.16A 2xz5B-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable		 2xz5B-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XZ5_E_ACHE1211_0
(SOLUBLE
ACETYLCHOLINE
RECEPTOR)		 6dk2 -
(-) 		4 / 7 GLN A 540
ILE A 529
TYR A 549
TYR A 527
 None
 1.14A 2xz5D-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable		 2xz5D-6dk2A:
undetectable
2xz5E-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3APX_A_Z80A190_1
(ALPHA-1-ACID
GLYCOPROTEIN 2)		 6dk2 -
(-) 		5 / 12 PHE A 205
LEU A 209
ARG A 212
GLU A 493
ALA A 134
 None
 1.49A 3apxA-6dk2A:
undetectable		 3apxA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3B2R_A_VDNA1_1
(CGMP-SPECIFIC
3',5'-CYCLIC
PHOSPHODIESTERASE)		 6dk2 -
(-) 		5 / 12 ILE A 127
LEU A 105
ALA A 108
ILE A 109
PHE A 182
 None
 1.12A 3b2rA-6dk2A:
undetectable		 3b2rA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6dk2 -
(-) 		5 / 12 LEU A 443
LEU A 486
THR A 407
TYR A 447
LEU A 304
 None
None
EDO  A 615 (-4.1A)
None
None
 1.18A 3fsuA-6dk2A:
undetectable		 3fsuA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_A_ADNA438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6dk2 -
(-) 		5 / 12 LEU A 405
LEU A  97
LEU A 135
GLY A 133
PHE A 205
 None
 1.35A 3g1uA-6dk2A:
undetectable		 3g1uA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3G1U_C_ADNC438_1
(ADENOSYLHOMOCYSTEINA
SE)		 6dk2 -
(-) 		5 / 12 LEU A 405
LEU A  97
LEU A 135
GLY A 133
PHE A 205
 None
 1.37A 3g1uC-6dk2A:
undetectable		 3g1uC-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HEC_A_STIA1_2
(MITOGEN-ACTIVATED
PROTEIN KINASE 14)		 6dk2 -
(-) 		4 / 4 LEU A 392
MET A 313
ILE A 341
ASP A 326
 None
 1.44A 3hecA-6dk2A:
2.2		 3hecA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6dk2 -
(-) 		5 / 12 ARG A 262
GLY A  51
SER A 399
ILE A 247
LEU A  47
 None
 0.98A 3iv6C-6dk2A:
undetectable		 3iv6C-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_1
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6dk2 -
(-) 		3 / 3 TYR A 254
GLY A 318
ASP A 319
 None
 0.68A 3ou6C-6dk2A:
undetectable		 3ou6C-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TJ7_C_ACTC610_0
(GBAA_1210 PROTEIN)		 6dk2 -
(-) 		3 / 3 ASN A 497
ALA A 501
ARG A 500
 None
 0.86A 3tj7C-6dk2A:
undetectable
3tj7D-6dk2A:
undetectable		 3tj7C-6dk2A:
undetectable
3tj7D-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WIP_D_ACHD301_0
(ACETYLCHOLINE-BINDIN
G PROTEIN)		 6dk2 -
(-) 		4 / 8 TYR A 527
THR A 137
TYR A 161
TRP A  94
 None
None
None
EDO  A 610 (-4.3A)
 1.38A 3wipD-6dk2A:
undetectable
3wipE-6dk2A:
undetectable		 3wipD-6dk2A:
undetectable
3wipE-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IB4_A_ERMA2001_2
(CHIMERA PROTEIN OF
HUMAN
5-HYDROXYTRYPTAMINE
RECEPTOR 2B AND E.
COLI SOLUBLE
CYTOCHROME B562)		 6dk2 -
(-) 		4 / 7 THR A 106
LEU A 136
GLN A 164
LEU A 167
 None
 0.98A 4ib4A-6dk2A:
3.7		 4ib4A-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QC6_B_KANB201_2
(BIFUNCTIONAL AAC/APH)		 6dk2 -
(-) 		3 / 3 LEU A 135
ASP A 138
TYR A 139
 None
 0.62A 4qc6B-6dk2A:
undetectable		 4qc6B-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QYN_A_RTLA201_0
(RETINOL-BINDING
PROTEIN 2)		 6dk2 -
(-) 		5 / 12 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.33A 4qynA-6dk2A:
undetectable		 4qynA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QZU_C_RTLC201_0
(RETINOL-BINDING
PROTEIN 2)		 6dk2 -
(-) 		5 / 12 PHE A 195
TYR A 131
VAL A 132
LEU A 405
LEU A  42
 None
 1.09A 4qzuC-6dk2A:
undetectable		 4qzuC-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4TZC_D_EF2D505_1
(PROTEIN CEREBLON)		 6dk2 -
(-) 		4 / 8 TYR A  62
THR A  76
HIS A  83
TRP A 551
 None
 1.49A 4tzcB-6dk2A:
undetectable
4tzcD-6dk2A:
undetectable		 4tzcB-6dk2A:
undetectable
4tzcD-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BMV_C_VLBC507_1
(TUBULIN BETA CHAIN
TUBULIN ALPHA-1B
CHAIN)		 6dk2 -
(-) 		4 / 6 ASP A  87
PRO A 144
TYR A 140
LEU A 136
 None
EDO  A 610 ( 4.9A)
None
None
 1.26A 5bmvB-6dk2A:
undetectable		 5bmvB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNU_A_BEZA319_0
(SHKAI2IB)		 6dk2 -
(-) 		4 / 5 GLN A 373
HIS A 376
ILE A 369
ILE A 309
 None
 1.09A 5dnuA-6dk2A:
undetectable		 5dnuA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DNV_A_BEZA304_0
(SHKAI2IB)		 6dk2 -
(-) 		4 / 5 GLN A 373
HIS A 376
ILE A 369
ILE A 309
 None
 1.06A 5dnvA-6dk2A:
undetectable		 5dnvA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DXB_B_ESTB601_1
(ESTROGEN RECEPTOR)		 6dk2 -
(-) 		5 / 11 ALA A 496
LEU A 555
ILE A 143
GLY A 133
LEU A 135
 None
 1.24A 5dxbB-6dk2A:
undetectable		 5dxbB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5G5G_B_ACTB1321_0
(PUTATIVE XANTHINE
DEHYDROGENASE YAGR
MOLYBDENUM-BINDING
SU SUBUNIT)		 6dk2 -
(-) 		3 / 3 THR A 453
ASP A 454
ALA A 455
 EDO  A 626 (-4.0A)
EDO  A 626 (-3.9A)
EDO  A 626 (-3.5A)
 0.00A 5g5gB-6dk2A:
undetectable		 5g5gB-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5GS4_A_ESTA603_1
(ESTROGEN RECEPTOR)		 6dk2 -
(-) 		5 / 12 ALA A 496
LEU A 555
ILE A 143
GLY A 133
LEU A 135
 None
 1.18A 5gs4A-6dk2A:
undetectable		 5gs4A-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OG9_B_TESB502_1
(-)		 6dk2 -
(-) 		5 / 12 LEU A 209
ILE A  49
MET A 102
LEU A 105
LEU A 136
 None
 0.95A 5og9B-6dk2A:
undetectable		 5og9B-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGK_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6dk2 -
(-) 		3 / 3 VAL A  56
TYR A  50
GLN A  48
 None
 0.71A 5qgkA-6dk2A:
undetectable		 5qgkA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGR_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6dk2 -
(-) 		3 / 3 VAL A  56
TYR A  50
GLN A  48
 None
 0.72A 5qgrA-6dk2A:
undetectable		 5qgrA-6dk2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5QGT_A_ACTA301_0
(PEROXISOMAL COENZYME
A DIPHOSPHATASE
NUDT7)		 6dk2 -
(-) 		3 / 3 VAL A  56
TYR A  50
GLN A  48
 None
 0.76A 5qgtA-6dk2A:
undetectable		 5qgtA-6dk2A:
undetectable