SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dkh'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1G5Y_B_9CRB501_1
(RETINOIC ACID
RECEPTOR RXR-ALPHA)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 12 ILE A 181
ALA A 158
TRP A 302
LEU A 192
ILE A 185
 None
 1.25A 1g5yB-6dkhA:
undetectable		 1g5yB-6dkhA:
16.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1IBG_H_OBNH1_2
(IGG2B-KAPPA 40-50
FAB (HEAVY CHAIN)
IGG2B-KAPPA 40-50
FAB (LIGHT CHAIN))		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 7 THR A 293
SER A 294
HIS A 160
SER A 289
 None
 1.17A 1ibgL-6dkhA:
undetectable		 1ibgL-6dkhA:
21.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HDN_L_TACL6888_1
(ELONGATION FACTOR
EF-TU)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 6 VAL A 202
THR A 251
SER A 176
PRO A 221
 None
 1.26A 2hdnJ-6dkhA:
undetectable
2hdnK-6dkhA:
undetectable
2hdnL-6dkhA:
undetectable		 2hdnJ-6dkhA:
11.04
2hdnK-6dkhA:
15.66
2hdnL-6dkhA:
11.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKW_B_DR7B100_2
(PROTEASE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 12 GLY A 214
ALA A 215
ASP A 216
VAL A 173
ILE A 185
 None
 0.87A 3ekwB-6dkhA:
undetectable		 3ekwB-6dkhA:
17.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 11 GLY A 177
ILE A 197
GLY A 210
LEU A 209
ILE A 185
 None
 0.89A 3em4U-6dkhA:
undetectable		 3em4U-6dkhA:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_A_PZIA802_0
(GLUTAMATE RECEPTOR 2)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		3 / 3 ASP A 201
ASN A 220
SER A 243
 None
 0.94A 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable		 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LSL_D_PZID802_0
(GLUTAMATE RECEPTOR 2)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		3 / 3 SER A 243
ASP A 201
ASN A 220
 None
 0.99A 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable		 3lslA-6dkhA:
undetectable
3lslD-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SUE_D_SUED1201_1
(NS3 PROTEASE, NS4A
PROTEIN)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 12 HIS A  65
GLY A  64
GLY A  41
SER A  42
SER A 289
 None
 1.11A 3sueD-6dkhA:
undetectable		 3sueD-6dkhA:
17.33
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 7 GLY A 214
ALA A 215
ASP A 216
ILE A 185
 None
 0.79A 3t3cA-6dkhA:
undetectable		 3t3cA-6dkhA:
26.73
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB513_1
(HEMOLYTIC LECTIN
CEL-III)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 6 CYH A 107
THR A 108
CYH A  93
ILE A 100
 ZN  A 401 (-2.3A)
None
ZN  A 401 (-2.3A)
None
 1.10A 3w9tB-6dkhA:
undetectable		 3w9tB-6dkhA:
14.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EOH_A_TEPA402_1
(PYRIDOXAL KINASE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 5 SER A 243
GLY A 177
THR A 251
ASP A 201
 None
 1.12A 4eohA-6dkhA:
4.7		 4eohA-6dkhA:
19.15
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_B_CHDB504_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 4 LEU A 155
PRO A 154
LEU A 184
ILE A 308
 None
 0.96A 4f4dB-6dkhA:
undetectable		 4f4dB-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FAK_A_SAMA201_0
(RIBOSOMAL RNA LARGE
SUBUNIT
METHYLTRANSFERASE H)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 10 LEU A 253
ILE A 284
GLY A 234
SER A 248
MET A 262
 None
 0.89A 4fakA-6dkhA:
undetectable		 4fakA-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HUA_A_FK5A201_1
(FK506-BINDING
PROTEIN 1)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 11 PHE A 126
VAL A  67
ILE A  68
PHE A 151
LEU A 314
 None
 1.48A 5huaA-6dkhA:
undetectable		 5huaA-6dkhA:
20.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5INZ_D_DVAD15_0
(THETA DEFENSIN-2,
D-PEPTIDE
THETA DEFENSIN-2,
L-PEPTIDE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		3 / 3 GLY A  94
CYH A  99
CYH A  96
 None
ZN  A 401 (-2.3A)
ZN  A 401 (-2.4A)
 0.81A 5inzB-6dkhA:
undetectable		 5inzB-6dkhA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M0O_A_EPAA502_1
(TERMINAL
OLEFIN-FORMING FATTY
ACID DECARBOXYLASE)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		5 / 10 PRO A 275
PRO A 221
ALA A 200
PHE A 174
VAL A 255
 None
 1.37A 5m0oA-6dkhA:
undetectable		 5m0oA-6dkhA:
11.14
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VKQ_C_PCFC1803_0
(NO MECHANORECEPTOR
POTENTIAL C ISOFORM
L)		 6dkh L-IDONATE
5-DEHYDROGENASE
(NAD(P)(+))
(Escherichia
coli) 		4 / 8 SER A 315
PHE A 151
PRO A 180
ILE A 181
 None
 1.15A 5vkqB-6dkhA:
undetectable
5vkqC-6dkhA:
undetectable		 5vkqB-6dkhA:
undetectable
5vkqC-6dkhA:
undetectable