SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dm8'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_A_MK1A401_2
(HIV-II PROTEASE)		 6dm8 -
(-) 		6 / 9 ALA A  61
ILE A-206
VAL A-180
ILE A-213
ILE A-155
ILE A-156
 None
 1.44A 1hshB-6dm8A:
undetectable		 1hshB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BYO_A_LNLA1216_1
(LIPOPROTEIN LPPX)		 6dm8 -
(-) 		4 / 5 LEU A 248
ILE A 163
LEU A 160
SER A 159
 6AK  A 401 (-4.3A)
None
None
None
 0.88A 2byoA-6dm8A:
undetectable		 2byoA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2DU8_B_BEZB1352_0
(D-AMINO-ACID OXIDASE)		 6dm8 -
(-) 		4 / 6 LEU A 167
TYR A 166
ILE A 275
GLY A 198
 None
None
6AK  A 401 ( 4.9A)
None
 0.91A 2du8B-6dm8A:
undetectable		 2du8B-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_H_BO2H1400_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6dm8 -
(-) 		5 / 11 THR A-122
GLN A 110
ALA A 109
ALA A  88
ALA A  86
 None
6AK  A 403 (-4.0A)
6AK  A 403 (-3.4A)
None
6AK  A 403 ( 4.4A)
 1.16A 2f16H-6dm8A:
undetectable
2f16I-6dm8A:
undetectable		 2f16H-6dm8A:
undetectable
2f16I-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F16_V_BO2V1401_1
(PROTEASOME COMPONENT
PUP1
PROTEASOME COMPONENT
PUP3)		 6dm8 -
(-) 		5 / 11 THR A-122
GLN A 110
ALA A 109
ALA A  88
ALA A  86
 None
6AK  A 403 (-4.0A)
6AK  A 403 (-3.4A)
None
6AK  A 403 ( 4.4A)
 1.14A 2f16V-6dm8A:
undetectable
2f16W-6dm8A:
undetectable		 2f16V-6dm8A:
undetectable
2f16W-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZW9_A_SAMA801_1
(LEUCINE CARBOXYL
METHYLTRANSFERASE 2)		 6dm8 -
(-) 		4 / 8 THR A-122
LEU A  70
ASP A  72
GLU A-104
 None
None
None
MAL  A 402 (-3.0A)
 1.04A 2zw9A-6dm8A:
undetectable		 2zw9A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_C_SVRC507_1
(PHOSPHOLIPASE A2)		 6dm8 -
(-) 		4 / 7 VAL A-105
GLY A  85
PRO A  14
LYS A  90
 6AK  A 403 ( 4.9A)
None
None
6AK  A 403 ( 4.1A)
 0.72A 3bjwC-6dm8A:
undetectable		 3bjwC-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BJW_G_SVRG506_1
(PHOSPHOLIPASE A2)		 6dm8 -
(-) 		4 / 8 VAL A-105
GLY A  85
PRO A  14
LYS A  90
 6AK  A 403 ( 4.9A)
None
None
6AK  A 403 ( 4.1A)
 0.95A 3bjwA-6dm8A:
undetectable		 3bjwA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IJX_H_HCZH800_1
(GLUTAMATE RECEPTOR 2)		 6dm8 -
(-) 		4 / 5 PRO A 270
SER A 266
LEU A 160
SER A 164
 None
 1.28A 3ijxH-6dm8A:
7.9		 3ijxH-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JYR_A_ACRA371_1
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 6dm8 -
(-) 		9 / 12 ASP A-201
LYS A-200
GLU A-171
GLU A-170
ALA A-152
ASP A-150
GLU A-104
PRO A -61
TRP A  15
 MAL  A 402 (-3.1A)
MAL  A 402 (-2.8A)
None
None
MAL  A 402 (-3.4A)
MAL  A 402 (-2.9A)
MAL  A 402 (-3.0A)
MAL  A 402 (-3.5A)
MAL  A 402 (-4.4A)
 0.44A 3jyrA-6dm8A:
60.4		 3jyrA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JYR_A_ACRA371_2
(MALTOSE-BINDING
PERIPLASMIC PROTEIN)		 6dm8 -
(-) 		6 / 7 ASN A-203
TRP A-153
GLU A -62
TYR A -60
MET A 115
TRP A 125
 MAL  A 402 ( 4.7A)
MAL  A 402 (-4.1A)
MAL  A 402 (-3.7A)
MAL  A 402 (-4.1A)
MAL  A 402 ( 4.8A)
MAL  A 402 (-3.7A)
 0.48A 3jyrA-6dm8A:
60.4		 3jyrA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KPD_B_SAMB1000_1
(UNCHARACTERIZED
PROTEIN MJ0100)		 6dm8 -
(-) 		3 / 3 ASN A -65
ASN A  12
GLU A  -1
 None
 0.93A 3kpdC-6dm8A:
undetectable		 3kpdC-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_B_RTZB1_1
(CYTOCHROME P450 2D6)		 6dm8 -
(-) 		5 / 12 PHE A -59
GLY A  85
LEU A  84
GLU A-104
ALA A  16
 None
None
None
MAL  A 402 (-3.0A)
None
 0.83A 3tbgB-6dm8A:
undetectable		 3tbgB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TBG_D_RTZD1_1
(CYTOCHROME P450 2D6)		 6dm8 -
(-) 		5 / 12 PHE A -59
GLY A  85
LEU A  84
GLU A-104
ALA A  16
 None
None
None
MAL  A 402 (-3.0A)
None
 0.82A 3tbgD-6dm8A:
undetectable		 3tbgD-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FGK_A_0TXA302_0
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6dm8 -
(-) 		4 / 6 PHE A 299
ILE A 245
PHE A 296
PHE A 300
 None
 1.27A 4fgkA-6dm8A:
undetectable		 4fgkA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4N48_A_SAMA601_1
(CAP-SPECIFIC MRNA
(NUCLEOSIDE-2'-O-)-M
ETHYLTRANSFERASE 1)		 6dm8 -
(-) 		4 / 5 ASN A  52
ALA A-164
GLY A-159
ASP A-201
 None
None
None
MAL  A 402 (-3.1A)
 0.98A 4n48A-6dm8A:
undetectable		 4n48A-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E4D_B_BEZB203_0
(HYDROXYNITRILE LYASE)		 6dm8 -
(-) 		4 / 4 VAL A-105
ALA A-103
ILE A 102
THR A 105
 6AK  A 403 ( 4.9A)
None
None
None
 1.16A 5e4dB-6dm8A:
undetectable		 5e4dB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_A_BEZA1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 6dm8 -
(-) 		4 / 6 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 0.99A 5ewuA-6dm8A:
undetectable		 5ewuA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EWU_B_BEZB1401_0
(MAGNESIUM-CHELATASE
SUBUNIT CHLH,
CHLOROPLASTIC)		 6dm8 -
(-) 		4 / 6 GLY A 198
SER A 250
VAL A 246
HIS A 205
 None
None
None
6AK  A 401 ( 4.4A)
 1.00A 5ewuB-6dm8A:
undetectable		 5ewuB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKT_B_TLFB601_0
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6dm8 -
(-) 		5 / 12 VAL A 128
LEU A -55
GLY A -28
ALA A -27
LEU A 146
 None
 1.25A 5iktB-6dm8A:
undetectable		 5iktB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_A_RBFA502_1
(RIBOFLAVIN LYASE)		 6dm8 -
(-) 		6 / 12 ALA A 127
ALA A 123
GLY A -49
ALA A -27
PHE A -46
VAL A -34
 None
 1.48A 5w4zA-6dm8A:
undetectable		 5w4zA-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W4Z_B_RBFB502_1
(RIBOFLAVIN LYASE)		 6dm8 -
(-) 		6 / 12 ALA A 127
ALA A 123
GLY A -49
ALA A -27
PHE A -46
VAL A -34
 None
 1.50A 5w4zB-6dm8A:
undetectable		 5w4zB-6dm8A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6B58_A_ACTA603_0
(FUMARATE REDUCTASE
FLAVOPROTEIN SUBUNIT)		 6dm8 -
(-) 		3 / 3 TYR A -60
ASN A  12
LEU A-102
 MAL  A 402 (-4.1A)
None
None
 0.66A 6b58A-6dm8A:
2.3		 6b58A-6dm8A:
undetectable