SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dt3'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_B_URFB2011_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.97A 1rxcB-6dt3A:
undetectable		 1rxcB-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_C_URFC2081_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 7 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.82A 1rxcC-6dt3A:
undetectable		 1rxcC-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_D_URFD2021_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 7 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.94A 1rxcD-6dt3A:
undetectable		 1rxcD-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_E_URFE2031_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.96A 1rxcE-6dt3A:
undetectable		 1rxcE-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_F_URFF2001_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 7 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.92A 1rxcF-6dt3A:
undetectable		 1rxcF-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_K_URFK2061_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.94A 1rxcK-6dt3A:
undetectable		 1rxcK-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RXC_L_URFL2071_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 7 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.96A 1rxcL-6dt3A:
undetectable		 1rxcL-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_A_URFA254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 1.00A 3kvvA-6dt3A:
undetectable		 3kvvA-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_B_URFB254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.91A 3kvvB-6dt3A:
undetectable		 3kvvB-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_C_URFC254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.98A 3kvvC-6dt3A:
undetectable		 3kvvC-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_D_URFD254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.90A 3kvvD-6dt3A:
undetectable		 3kvvD-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_E_URFE254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.94A 3kvvE-6dt3A:
undetectable		 3kvvE-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KVV_F_URFF254_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.96A 3kvvF-6dt3A:
undetectable		 3kvvF-6dt3A:
15.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4D7B_A_TCWA1126_1
(TRANSTHYRETIN)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 LEU A 122
LEU A 141
SER A 136
THR A 134
 None
 1.26A 4d7bB-6dt3A:
undetectable		 4d7bB-6dt3A:
21.82
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_A_URFA1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.89A 4e1vA-6dt3A:
undetectable		 4e1vA-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_B_URFB1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 7 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.91A 4e1vB-6dt3A:
undetectable		 4e1vB-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_C_URFC1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.88A 4e1vC-6dt3A:
undetectable		 4e1vC-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_D_URFD1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.92A 4e1vD-6dt3A:
undetectable		 4e1vD-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_E_URFE1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.92A 4e1vE-6dt3A:
undetectable		 4e1vE-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_F_URFF1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.87A 4e1vF-6dt3A:
undetectable		 4e1vF-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E1V_H_URFH1301_1
(URIDINE
PHOSPHORYLASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 8 GLY A  37
ARG A  52
ILE A   6
VAL A   7
 None
 0.92A 4e1vH-6dt3A:
undetectable		 4e1vH-6dt3A:
18.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR3_A_GLYA701_0
(GLYCINE--TRNA LIGASE)		 6dt3 NUCLEOSIDE
TRIPHOSPHATASE NUDI
(Klebsiella
pneumoniae) 		4 / 6 ARG A   4
GLU A  57
ARG A  26
GLU A 110
 None
 1.12A 4kr3A-6dt3A:
undetectable		 4kr3A-6dt3A:
undetectable