SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dub'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MCN_P_DHIP1_0
(IMMUNOGLOBULIN
LAMBDA DIMER MCG
(LIGHT CHAIN)
PEPTIDE
N-ACETYL-D-HIS-L-PRO
-NH2)		 6dub -
(-) 		3 / 3 PHE A 177
TYR A 184
PRO A 179
 UNX  A 307 ( 4.5A)
None
None
 0.50A 1mcnA-6dubA:
undetectable
1mcnB-6dubA:
undetectable
1mcnP-6dubA:
undetectable		 1mcnA-6dubA:
undetectable
1mcnB-6dubA:
undetectable
1mcnP-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NNH_B_9CRB502_1
(CYTOCHROME P450 2C8)		 6dub -
(-) 		5 / 10 SER A 252
ILE A 249
LEU A 220
VAL A 192
ILE A 187
 None
None
UNX  A 316 ( 4.8A)
UNX  A 316 ( 4.3A)
None
 1.11A 2nnhB-6dubA:
undetectable		 2nnhB-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_C_TFPC202_1
(PROTEIN S100-A4)		 6dub -
(-) 		5 / 11 SER A  94
LEU A 105
PHE A 104
ILE A 219
ASP A 122
 None
None
UNX  A 304 ( 4.8A)
None
SAH  A 301 ( 4.9A)
 1.10A 3ko0A-6dubA:
undetectable
3ko0B-6dubA:
undetectable
3ko0C-6dubA:
undetectable
3ko0D-6dubA:
undetectable		 3ko0A-6dubA:
undetectable
3ko0B-6dubA:
undetectable
3ko0C-6dubA:
undetectable
3ko0D-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_F_TFPF202_1
(PROTEIN S100-A4)		 6dub -
(-) 		5 / 11 ASP A 122
LEU A 105
PHE A 104
ILE A 219
SER A  94
 SAH  A 301 ( 4.9A)
None
UNX  A 304 ( 4.8A)
None
None
 1.01A 3ko0E-6dubA:
undetectable
3ko0F-6dubA:
undetectable
3ko0G-6dubA:
undetectable
3ko0H-6dubA:
undetectable		 3ko0E-6dubA:
undetectable
3ko0F-6dubA:
undetectable
3ko0G-6dubA:
undetectable
3ko0H-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_N_TFPN202_1
(PROTEIN S100-A4)		 6dub -
(-) 		5 / 11 SER A  94
ASP A 122
LEU A 105
PHE A 104
ILE A 219
 None
SAH  A 301 ( 4.9A)
None
UNX  A 304 ( 4.8A)
None
 1.08A 3ko0K-6dubA:
undetectable
3ko0L-6dubA:
undetectable
3ko0M-6dubA:
undetectable
3ko0N-6dubA:
undetectable		 3ko0K-6dubA:
undetectable
3ko0L-6dubA:
undetectable
3ko0M-6dubA:
undetectable
3ko0N-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_A_SAMA300_0
(PUTATIVE
METHYLTRANSFERASE)		 6dub -
(-) 		5 / 12 ARG A 129
GLY A 124
GLY A 126
ASP A 146
SER A 173
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
UNX  A 311 (-4.0A)
 0.82A 3t7sA-6dubA:
17.0		 3t7sA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_B_SAMB300_0
(PUTATIVE
METHYLTRANSFERASE)		 6dub -
(-) 		5 / 12 ARG A 129
GLY A 124
GLY A 126
ASP A 146
SER A 173
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
UNX  A 311 (-4.0A)
 0.80A 3t7sB-6dubA:
17.4		 3t7sB-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T7S_D_SAMD300_0
(PUTATIVE
METHYLTRANSFERASE)		 6dub -
(-) 		5 / 12 ARG A 129
GLY A 124
GLY A 126
ASP A 146
SER A 173
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
UNX  A 311 (-4.0A)
 0.77A 3t7sD-6dubA:
17.3		 3t7sD-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_A_SAMA301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6dub -
(-) 		5 / 12 GLY A 124
GLY A 126
ASP A 146
HIS A 195
LEU A 196
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.9A)
None
 0.42A 4iv8A-6dubA:
16.9		 4iv8A-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IV8_B_SAMB301_0
(PHOSPHOETHANOLAMINE
N-METHYLTRANSFERASE,
PUTATIVE)		 6dub -
(-) 		5 / 12 GLY A 124
GLY A 126
ASP A 146
HIS A 195
LEU A 196
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.9A)
None
 0.39A 4iv8B-6dubA:
17.0		 4iv8B-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 6dub -
(-) 		12 / 12 TYR A  76
MET A  86
GLY A 124
VAL A 130
MET A 147
SER A 173
LEU A 174
GLN A 190
TRP A 191
VAL A 192
HIS A 195
LEU A 196
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-3.5A)
UNX  A 311 (-4.0A)
SAH  A 301 (-4.0A)
SAH  A 301 (-4.2A)
GOL  A 303 ( 4.9A)
UNX  A 316 ( 4.3A)
SAH  A 301 (-3.9A)
None
 0.11A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_0
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 6dub -
(-) 		8 / 12 TYR A  76
MET A  86
GLY A 124
VAL A 130
MET A 148
GLN A 190
TRP A 191
HIS A 195
 SAH  A 301 (-3.7A)
SAH  A 301 (-3.9A)
SAH  A 301 (-3.9A)
None
SAH  A 301 (-4.4A)
SAH  A 301 (-4.2A)
GOL  A 303 ( 4.9A)
SAH  A 301 (-3.9A)
 1.13A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 6dub -
(-) 		4 / 5 GLY A 126
ARG A 129
ASP A 146
MET A 147
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.5A)
 0.95A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UBB_A_SAMA301_1
(ALPHA N-TERMINAL
PROTEIN
METHYLTRANSFERASE 1B)		 6dub -
(-) 		5 / 5 GLY A 126
ARG A 129
ASP A 146
MET A 148
GLN A 175
 SAH  A 301 (-3.0A)
SAH  A 301 (-3.9A)
SAH  A 301 (-2.8A)
SAH  A 301 (-4.4A)
SAH  A 301 (-3.5A)
 0.14A 5ubbA-6dubA:
38.7		 5ubbA-6dubA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5WY0_A_SAMA800_0
(SMALL RNA
2'-O-METHYLTRANSFERA
SE)		 6dub -
(-) 		5 / 12 GLY A 124
GLY A 126
ASP A 146
HIS A 195
LEU A 196
 SAH  A 301 (-3.9A)
SAH  A 301 (-3.0A)
SAH  A 301 (-2.8A)
SAH  A 301 (-3.9A)
None
 0.55A 5wy0A-6dubA:
13.5		 5wy0A-6dubA:
undetectable