SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dux'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1B02_A_C2FA281_0
(PROTEIN (THYMIDYLATE
SYNTHASE))		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 11 ALA A 418
THR A 410
TRP A 436
ASP A 427
ALA A 430
 None
 1.11A 1b02A-6duxA:
undetectable		 1b02A-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4S_A_TPVA201_1
(PROTEIN (HIV-1
PROTEASE))		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 10 ASP A 351
VAL A 356
ILE A 347
GLY A 345
PRO A 369
 None
 1.21A 1d4sA-6duxA:
undetectable		 1d4sA-6duxA:
23.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_A_EAAA223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A 195
GLY A 202
LEU A 264
MET A 383
 None
 1.22A 1gsfA-6duxA:
undetectable		 1gsfA-6duxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_B_EAAB223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A 195
GLY A 202
LEU A 264
MET A 383
 None
 1.22A 1gsfB-6duxA:
undetectable		 1gsfB-6duxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GSF_D_EAAD223_1
(GLUTATHIONE
TRANSFERASE A1-1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 8 TYR A 195
GLY A 202
LEU A 264
MET A 383
 None
 1.22A 1gsfD-6duxA:
undetectable		 1gsfD-6duxA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_B_THAB2_1
(LIVER
CARBOXYLESTERASE I)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 11 LEU A  56
PHE A  65
VAL A 295
LEU A  21
LEU A 313
 None
None
None
None
ACT  A 503 ( 4.3A)
 1.11A 1mx1B-6duxA:
undetectable		 1mx1B-6duxA:
9.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OSV_B_CHCB201_2
(BILE ACID RECEPTOR)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 5 HIS A 440
ARG A 400
ILE A 409
HIS A 403
 None
 1.42A 1osvB-6duxA:
undetectable		 1osvB-6duxA:
18.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 ALA A 117
GLY A 112
GLY A 115
ILE A 409
GLY A 107
 None
 1.04A 2qe6B-6duxA:
2.6		 2qe6B-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3C6G_A_VD3A701_1
(CYTOCHROME P450 2R1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 428
ALA A 284
VAL A 415
ILE A 424
THR A 414
 None
 0.96A 3c6gA-6duxA:
undetectable		 3c6gA-6duxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3CZH_B_D2VB602_1
(CYTOCHROME P450 2R1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 LEU A 428
ALA A 284
VAL A 415
ILE A 424
THR A 414
 None
 1.04A 3czhB-6duxA:
undetectable		 3czhB-6duxA:
12.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ELZ_B_CHDB153_0
(ILEAL BILE
ACID-BINDING PROTEIN)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 6 ILE A 302
THR A  16
PHE A  37
PHE A  65
 None
 1.14A 3elzB-6duxA:
undetectable		 3elzB-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3GAN_A_SVRA158_1
(UNCHARACTERIZED
PROTEIN AT3G22680)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 11 VAL A 362
PRO A 367
ILE A 165
ILE A 340
PRO A 342
 None
 1.45A 3ganA-6duxA:
undetectable		 3ganA-6duxA:
19.61
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  12
TYR A 118
SER A 122
VAL A 152
VAL A 126
 NAD  A 501 (-3.2A)
NAD  A 501 (-4.6A)
None
None
None
 1.25A 4ffwA-6duxA:
undetectable		 4ffwA-6duxA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_B_715B801_1
(DIPEPTIDYL PEPTIDASE
4)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  12
TYR A 118
SER A 122
VAL A 152
VAL A 126
 NAD  A 501 (-3.2A)
NAD  A 501 (-4.6A)
None
None
None
 1.27A 4ffwB-6duxA:
undetectable		 4ffwB-6duxA:
8.04
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 8 ARG A  93
TYR A  90
ARG A 291
ASP A 170
 None
NAD  A 501 (-4.6A)
ACT  A 503 (-3.2A)
NAD  A 501 ( 4.5A)
 1.28A 4kr4C-6duxA:
undetectable		 4kr4C-6duxA:
15.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4PGH_D_SAMD401_0
(CAFFEIC ACID
O-METHYLTRANSFERASE)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 GLY A  11
GLY A  12
ASP A  39
PHE A  75
ILE A   8
 None
NAD  A 501 (-3.2A)
NAD  A 501 (-2.8A)
None
None
 1.12A 4pghD-6duxA:
undetectable		 4pghD-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5A06_D_SORD1341_0
(ALDOSE-ALDOSE
OXIDOREDUCTASE)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		4 / 6 GLU A 109
GLY A 115
GLY A 114
ASP A  96
 NAD  A 501 (-2.9A)
None
None
None
 0.98A 5a06D-6duxA:
6.9		 5a06D-6duxA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FHZ_D_READ602_1
(ALDEHYDE
DEHYDROGENASE FAMILY
1 MEMBER A3)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A 175
GLU A 176
GLY A 177
ARG A 188
ASN A 242
 None
 1.30A 5fhzD-6duxA:
3.9		 5fhzD-6duxA:
11.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGW_A_CTYA404_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E II)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		5 / 12 ILE A  19
GLY A  18
SER A  34
ILE A  63
PHE A  65
 None
ACT  A 503 (-3.4A)
None
None
None
 1.41A 5igwA-6duxA:
undetectable		 5igwA-6duxA:
12.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWN_C_AQ4C602_1
(CYTOCHROME P450 1A1)		 6dux 6-PHOSPHO-ALPHA-GLUC
OSIDASE
(Klebsiella
pneumoniae) 		3 / 3 SER A   5
SER A  34
ALA A  73
 None
 0.70A 6dwnC-6duxA:
undetectable		 6dwnC-6duxA:
16.05