SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dw1'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1GTB_A_PZQA901_0
(GLUTATHIONE
S-TRANSFERASE)		 6dw1

(;
) 		3 / 3 GLN E  64
TYR D 220
ARG D 176
 None
 0.80A 1gtbA-6dw1E:
undetectable		 1gtbA-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1MX1_E_THAE5_1
(LIVER
CARBOXYLESTERASE I)		 6dw1 -
(-) 		5 / 12 VAL E  12
VAL E  87
LEU E  81
LEU E  83
LEU E  91
 None
 1.18A 1mx1E-6dw1E:
undetectable		 1mx1E-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PXX_D_DIFD3701_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6dw1 -
(-) 		5 / 10 VAL E 124
LEU E 118
TYR E  23
VAL E  87
ALA E  88
 None
 1.25A 1pxxD-6dw1E:
undetectable		 1pxxD-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QKN_A_RALA600_1
(ESTROGEN RECEPTOR
BETA)		 6dw1 -
(-) 		6 / 12 LEU E  59
THR E  58
ALA E 134
LEU E 210
ILE E 181
ILE E 188
 None
 1.31A 1qknA-6dw1E:
undetectable		 1qknA-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOU_A_CQAA403_0
(HISTAMINE
N-METHYLTRANSFERASE)		 6dw1

(;
) 		4 / 8 ASP D 110
GLY E 127
ASP E  43
THR D 216
 None
 1.04A 2aouA-6dw1D:
undetectable		 2aouA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B8J_B_ADNB331_1
(CLASS B ACID
PHOSPHATASE)		 6dw1 -
(-) 		5 / 10 SER E 211
PHE E 212
TYR E  57
LEU E  59
GLY E 177
 NAG  E 501 (-2.3A)
None
None
None
None
 1.27A 2b8jB-6dw1E:
undetectable		 2b8jB-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_D_SALD5006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6dw1 -
(-) 		4 / 5 ARG E 129
THR E 131
LEU E  59
ALA E  45
 None
 1.45A 2e1qD-6dw1E:
undetectable		 2e1qD-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HZQ_A_STRA300_1
(APOLIPOPROTEIN D)		 6dw1 -
(-) 		4 / 7 THR D 209
ALA D 149
TYR D  72
ASN D 115
 None
 1.15A 2hzqA-6dw1D:
undetectable		 2hzqA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_A_SAMA400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6dw1

(;
) 		3 / 3 ASN E 113
ARG E 129
ASP D 148
 None
 0.84A 2qe6A-6dw1E:
undetectable		 2qe6A-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_1
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6dw1

(;
) 		3 / 3 ASN E 113
ARG E 129
ASP D 148
 None
 0.88A 2qe6B-6dw1E:
undetectable		 2qe6B-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XNR_A_ACTA1001_0
(NUCLEAR
POLYADENYLATED
RNA-BINDING PROTEIN
3)		 6dw1

(;
) 		3 / 3 SER D 217
ARG E  41
GLN E  64
 None
 0.98A 2xnrA-6dw1D:
undetectable		 2xnrA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2YGO_A_PCFA1213_1
(WNT INHIBITORY
FACTOR 1)		 6dw1 -
(-) 		4 / 6 LEU E  79
ILE E  77
PRO E 120
VAL E 111
 None
 1.12A 2ygoA-6dw1E:
undetectable		 2ygoA-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_D_TFPD202_1
(PROTEIN S100-A4)		 6dw1
() 		5 / 11 LEU D 167
PHE D 113
ILE D 147
ASP E  48
SER E  46
 None
 1.30A 3ko0C-6dw1D:
undetectable
3ko0D-6dw1D:
undetectable
3ko0E-6dw1D:
undetectable
3ko0F-6dw1D:
undetectable		 3ko0C-6dw1D:
undetectable
3ko0D-6dw1D:
undetectable
3ko0E-6dw1D:
undetectable
3ko0F-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_I_TFPI202_1
(PROTEIN S100-A4)		 6dw1
() 		5 / 12 ASP E  48
SER E  46
LEU D 167
PHE D 113
ILE D 147
 None
 1.26A 3ko0G-6dw1E:
undetectable
3ko0H-6dw1E:
undetectable
3ko0I-6dw1E:
undetectable
3ko0J-6dw1E:
undetectable		 3ko0G-6dw1E:
undetectable
3ko0H-6dw1E:
undetectable
3ko0I-6dw1E:
undetectable
3ko0J-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KO0_T_TFPT202_1
(PROTEIN S100-A4)		 6dw1
() 		5 / 11 ASP E  48
SER E  46
LEU D 167
PHE D 113
ILE D 147
 None
 1.23A 3ko0Q-6dw1E:
undetectable
3ko0R-6dw1E:
undetectable
3ko0S-6dw1E:
undetectable
3ko0T-6dw1E:
undetectable		 3ko0Q-6dw1E:
undetectable
3ko0R-6dw1E:
undetectable
3ko0S-6dw1E:
undetectable
3ko0T-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LB3_B_4CHB192_0
(DEHALOPEROXIDASE A)		 6dw1 -
(-) 		4 / 6 PHE C 216
HIS C 215
THR C 196
VAL C 197
 None
 1.18A 3lb3B-6dw1C:
undetectable		 3lb3B-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ME6_B_CGEB501_1
(CYTOCHROME P450 2B4)		 6dw1 -
(-) 		4 / 8 ILE E  47
ALA E 134
THR E 132
VAL E  44
 None
 0.82A 3me6B-6dw1E:
undetectable		 3me6B-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3RV5_A_DXCA92_0
(TROPONIN C, SLOW
SKELETAL AND CARDIAC
MUSCLES)		 6dw1 -
(-) 		4 / 4 LYS E 215
PHE E 186
PHE E 212
VAL E 178
 None
 1.33A 3rv5A-6dw1E:
undetectable
3rv5B-6dw1E:
undetectable		 3rv5A-6dw1E:
undetectable
3rv5B-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ACB_C_DXCC1478_0
(TRANSLATION
ELONGATION FACTOR
SELB)		 6dw1

(;
) 		4 / 6 SER D 116
THR D  73
ILE D 147
THR E 131
 None
 1.01A 4acbC-6dw1D:
undetectable		 4acbC-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_B_ML1B302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6dw1 -
(-) 		4 / 6 GLY E  39
PHE E  63
ILE E  42
PHE E  98
 None
 1.11A 4qogA-6dw1E:
undetectable
4qogB-6dw1E:
undetectable		 4qogA-6dw1E:
undetectable
4qogB-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XJ7_A_ADNA303_1
(5'/3'-NUCLEOTIDASE
SURE)		 6dw1 -
(-) 		5 / 10 GLY C 124
ILE C  93
PRO C  31
LEU C  74
LEU C 126
 None
 1.20A 4xj7A-6dw1C:
undetectable
4xj7B-6dw1C:
undetectable		 4xj7A-6dw1C:
undetectable
4xj7B-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HFJ_H_SAMH301_0
(ADENINE SPECIFIC DNA
METHYLTRANSFERASE
(DPNA))		 6dw1 -
(-) 		5 / 12 ALA C 181
THR C 129
GLN C  67
PHE C  45
THR C  42
 None
ABU  C 405 (-2.7A)
None
None
None
 1.23A 5hfjH-6dw1C:
undetectable		 5hfjH-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 6dw1 -
(-) 		4 / 8 SER C 158
THR C 162
THR C 206
SER C 204
 None
 0.99A 5l4eA-6dw1C:
19.9
5l4eB-6dw1C:
19.9
5l4eC-6dw1C:
19.9
5l4eD-6dw1C:
19.9
5l4eE-6dw1C:
19.8		 5l4eA-6dw1C:
undetectable
5l4eB-6dw1C:
undetectable
5l4eC-6dw1C:
undetectable
5l4eD-6dw1C:
undetectable
5l4eE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6dw1 -
(-) 		3 / 3 THR C  98
THR C 171
LEU C 127
 None
 0.67A 5m66D-6dw1C:
undetectable		 5m66D-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M66_D_ADND502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6dw1 -
(-) 		3 / 3 THR C 214
THR C  98
LEU C 132
 None
 0.65A 5m66D-6dw1C:
undetectable		 5m66D-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z3J_A_NCAA302_0
(ABRIN A-CHAIN)		 6dw1 -
(-) 		4 / 6 TYR D 220
VAL D 221
ILE D 179
GLU D 178
 None
 0.94A 5z3jA-6dw1D:
undetectable		 5z3jA-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6A94_B_ZOTB3001_0
(5-HYDROXYTRYPTAMINE
RECEPTOR 2A,SOLUBLE
CYTOCHROME B562)		 6dw1 -
(-) 		5 / 12 SER D 195
VAL D  65
GLY D  63
SER D  61
VAL D 204
 None
 1.00A 6a94B-6dw1D:
undetectable		 6a94B-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 6dw1

(;
) 		8 / 11 HIS C 101
TYR C 159
SER C 204
THR C 206
TYR D  58
PHE D  77
ALA D  79
THR D 142
 None
 0.74A 6d6tD-6dw1C:
30.1
6d6tE-6dw1C:
25.7		 6d6tD-6dw1C:
undetectable
6d6tE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 6dw1

(;
) 		8 / 11 HIS C 101
TYR C 159
SER C 205
TYR C 209
TYR D  58
PHE D  77
ALA D  79
THR D 142
 None
 0.62A 6d6tD-6dw1C:
30.1
6d6tE-6dw1C:
25.7		 6d6tD-6dw1C:
undetectable
6d6tE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 6dw1

(;
) 		8 / 11 HIS C 101
TYR C 159
THR C 206
TYR C 209
TYR D  58
PHE D  77
ALA D  79
THR D 142
 None
 0.45A 6d6tD-6dw1C:
30.1
6d6tE-6dw1C:
25.7		 6d6tD-6dw1C:
undetectable
6d6tE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6T_D_FYPD406_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
HUMAN GABA-A
RECEPTOR SUBUNIT
GAMMA-2)		 6dw1

(;
) 		5 / 11 SER C 204
THR C 206
TYR D  58
PHE D  77
THR D 142
 None
 1.48A 6d6tD-6dw1C:
30.1
6d6tE-6dw1C:
25.7		 6d6tD-6dw1C:
undetectable
6d6tE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6U_D_FYPD410_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2)		 6dw1

(;
) 		6 / 9 HIS C 101
TYR C 159
SER C 204
SER C 205
ALA D  79
THR D 142
 None
 1.01A 6d6uD-6dw1C:
30.2
6d6uE-6dw1C:
27.0		 6d6uD-6dw1C:
undetectable
6d6uE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6D6U_D_FYPD410_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
GAMMA-2,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT GAMMA-2)		 6dw1

(;
) 		7 / 9 HIS C 101
TYR C 159
SER C 205
TYR C 209
TYR D  58
ALA D  79
THR D 142
 None
 0.62A 6d6uD-6dw1C:
30.2
6d6uE-6dw1C:
27.0		 6d6uD-6dw1C:
undetectable
6d6uE-6dw1C:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECT_A_SAMA1300_1
(STIE PROTEIN)		 6dw1

(;
) 		4 / 5 THR E 123
THR D 216
GLN E  64
ASP D 219
 None
 1.35A 6ectA-6dw1E:
undetectable		 6ectA-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6ECX_A_SAMA1301_1
(STIE PROTEIN)		 6dw1

(;
) 		4 / 5 THR E 123
THR D 216
GLN E  64
ASP D 219
 None
 1.39A 6ecxA-6dw1E:
undetectable		 6ecxA-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_C_ADNC501_2
(-)		 6dw1 -
(-) 		4 / 5 GLN E  65
THR E  60
HIS E 107
GLY E 127
 None
 1.15A 6gbnC-6dw1E:
undetectable		 6gbnC-6dw1E:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUO_D_08HD501_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 6dw1

(;
) 		8 / 8 TYR D  58
ASN D  60
PHE D  77
PHE C  99
HIS C 101
VAL C 202
SER C 204
TYR C 209
 None
 0.61A 6huoC-6dw1D:
29.7
6huoD-6dw1D:
29.0		 6huoC-6dw1D:
undetectable
6huoD-6dw1D:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6HUP_D_DZPD2001_0
(GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT
ALPHA-1,GAMMA-AMINOB
UTYRIC ACID RECEPTOR
SUBUNIT ALPHA-1
GAMMA-AMINOBUTYRIC
ACID RECEPTOR
SUBUNIT GAMMA-2)		 6dw1

(;
) 		9 / 9 TYR D  58
ASN D  60
PHE D  77
PHE C  99
HIS C 101
TYR C 159
VAL C 202
SER C 204
TYR C 209
 None
 0.64A 6hupC-6dw1D:
29.5
6hupD-6dw1D:
28.8		 6hupC-6dw1D:
undetectable
6hupD-6dw1D:
undetectable