SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dxo'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_A_C2FA995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6dxo RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
BLDN
(Streptomyces
venezuelae;
Streptomyces
venezuelae) 		5 / 12 GLN A 130
THR A 134
GLN D  57
LEU D  58
THR A  44
 None
 1.37A 3fsuA-6dxoA:
undetectable		 3fsuA-6dxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FSU_E_C2FE995_0
(5,10-METHYLENETETRAH
YDROFOLATE REDUCTASE)		 6dxo RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
BLDN
(Streptomyces
venezuelae;
Streptomyces
venezuelae) 		5 / 11 GLN A 130
THR A 134
GLN D  57
LEU D  58
THR A  44
 None
 1.35A 3fsuE-6dxoA:
undetectable		 3fsuE-6dxoA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZO1_X_T3X500_1
(THYROID HORMONE
RECEPTOR BETA)		 6dxo BLDN
RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
(Streptomyces
venezuelae) 		5 / 12 ILE A  55
ALA A   7
MET D  77
MET D  74
ARG D  67
 None
 1.35A 4zo1X-6dxoA:
undetectable		 4zo1X-6dxoA:
14.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5PHH_A_LDPA414_1
(LYSINE-SPECIFIC
DEMETHYLASE 4D)		 6dxo BLDN
RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
(Streptomyces
venezuelae) 		4 / 6 GLU A  41
ARG A 123
LEU D  58
TYR A  27
 None
 1.09A 5phhA-6dxoA:
undetectable		 5phhA-6dxoA:
14.01
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z84_J_CHDJ101_0
(CYTOCHROME C OXIDASE
SUBUNIT 7A1,
MITOCHONDRIAL)		 6dxo RNA POLYMERASE
ECF-SUBFAMILY SIGMA
FACTOR
(Streptomyces
venezuelae) 		3 / 3 TYR A 162
ARG A 163
THR A 167
 None
 0.73A 5z84J-6dxoA:
undetectable		 5z84J-6dxoA:
undetectable