SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dxt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2XPW_A_OTCA222_1
(TETRACYCLINE
REPRESSOR PROTEIN
CLASS D)		 6dxt -
(-) 		5 / 12 LEU A 244
HIS A 275
PRO A 270
VAL A 176
SER A 182
 None
 1.43A 2xpwA-6dxtA:
undetectable		 2xpwA-6dxtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM4_B_8PRB603_1
(TRANSPORTER)		 6dxt -
(-) 		5 / 12 ASP A 262
ALA A 233
TYR A 237
VAL A 234
THR A 213
 None
HHY  A 701 ( 3.7A)
None
HHY  A 701 ( 4.5A)
None
 1.29A 4mm4B-6dxtA:
undetectable		 4mm4B-6dxtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X1K_D_LOCD502_1
(TUBULIN ALPHA CHAIN
TUBULIN BETA CHAIN)		 6dxt -
(-) 		4 / 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 UNX  A 702 ( 4.2A)
None
None
None
 0.77A 4x1kC-6dxtA:
undetectable		 4x1kC-6dxtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NM5_B_LOCB502_1
(TUBULIN ALPHA-1B
CHAIN
TUBULIN BETA-2B
CHAIN)		 6dxt -
(-) 		4 / 4 ASN A 211
SER A 260
ALA A 245
VAL A 246
 UNX  A 702 ( 4.2A)
None
None
None
 0.81A 5nm5A-6dxtA:
undetectable		 5nm5A-6dxtA:
undetectable