SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6dzs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7B_A_HLTA4001_1
(SERUM ALBUMIN)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 5 ARG A  72
ALA A  11
ASP A  74
GLY A   9
 None
 0.87A 1e7bA-6dzsA:
1.2		 1e7bA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1E7C_A_HLTA4001_1
(SERUM ALBUMIN)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 5 ARG A  72
ALA A  11
ASP A  74
GLY A   9
 None
 0.89A 1e7cA-6dzsA:
undetectable		 1e7cA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_A_SAMA801_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 6 ASP A 320
TYR A 129
ASP A 127
ASN A 327
 None
 0.94A 1rjdA-6dzsA:
undetectable		 1rjdA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_B_SAMB802_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 6 ASP A 320
TYR A 129
ASP A 127
ASN A 327
 None
 0.95A 1rjdB-6dzsA:
undetectable		 1rjdB-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RJD_C_SAMC803_1
(CARBOXY METHYL
TRANSFERASE FOR
PROTEIN PHOSPHATASE
2A CATALYTIC SUBUNIT)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 6 ASP A 320
TYR A 129
ASP A 127
ASN A 327
 None
 0.98A 1rjdC-6dzsA:
undetectable		 1rjdC-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2NYR_B_SVRB401_4
(NAD-DEPENDENT
DEACETYLASE
SIRTUIN-5)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 5 ALA A 308
ALA A 204
ALA A 252
VAL A 291
 NAP  A 500 ( 3.9A)
None
None
None
 0.90A 2nyrB-6dzsA:
5.8		 2nyrB-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A2Q_A_ACAA602_1
(6-AMINOHEXANOATE-CYC
LIC-DIMER HYDROLASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 7 ASN A 161
ALA A 205
ALA A 206
ALA A 208
 None
 0.79A 3a2qA-6dzsA:
undetectable		 3a2qA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3M8P_A_65BA562_0
(REVERSE
TRANSCRIPTASE/RIBONU
CLEASE H
P51 RT)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 11 LEU A  13
VAL A  75
VAL A 102
LEU A  69
GLU A  80
 None
None
None
None
NAP  A 500 ( 4.7A)
 1.39A 3m8pA-6dzsA:
4.8
3m8pB-6dzsA:
2.4		 3m8pA-6dzsA:
undetectable
3m8pB-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU6_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 LEU A 277
ALA A 241
GLY A 245
LEU A 274
ALA A 236
 None
 1.28A 3ou6C-6dzsA:
3.2		 3ou6C-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_C_SAMC300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 LEU A 277
ALA A 241
GLY A 245
LEU A 274
ALA A 236
 None
 1.26A 3ou7C-6dzsA:
3.0		 3ou7C-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3T3C_A_017A201_1
(HIV-1 PROTEASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 7 GLY A 175
ALA A 176
ASP A 177
ASP A 180
 None
 0.68A 3t3cA-6dzsA:
undetectable		 3t3cA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FFW_A_715A801_1
(DIPEPTIDYL PEPTIDASE
4)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 GLU A 436
GLY A 437
ARG A 300
SER A 267
VAL A 225
 None
 1.41A 4ffwA-6dzsA:
4.3		 4ffwA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_A_AERA601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 LEU A  33
ALA A 325
ILE A  25
GLY A 319
VAL A  79
 None
 1.11A 4nkvA-6dzsA:
undetectable		 4nkvA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_C_AERC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 LEU A  33
ALA A 325
ILE A  25
GLY A 319
VAL A  79
 None
 1.13A 4nkvC-6dzsA:
undetectable		 4nkvC-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKV_D_AERD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 LEU A  33
ALA A 325
ILE A  25
GLY A 319
VAL A  79
 None
 1.14A 4nkvD-6dzsA:
undetectable		 4nkvD-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5ESG_A_1YNA701_2
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 4 LEU A 144
TYR A 129
PRO A 139
ILE A 138
 None
 1.27A 5esgA-6dzsA:
undetectable		 5esgA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_C_URFC301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		3 / 3 ARG A 336
HIS A 125
ARG A 333
 None
 1.04A 5iaoC-6dzsA:
2.2		 5iaoC-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IAO_F_URFF301_1
(BIFUNCTIONAL PROTEIN
PYRR)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		3 / 3 ARG A 336
HIS A 125
ARG A 333
 None
 1.08A 5iaoF-6dzsA:
2.0		 5iaoF-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IGI_A_ZITA402_1
(MACROLIDE
2'-PHOSPHOTRANSFERAS
E)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 MET A 318
ILE A  26
ALA A 105
VAL A 103
GLY A  83
 None
None
NAP  A 500 (-3.3A)
None
NAP  A 500 ( 3.2A)
 1.13A 5igiA-6dzsA:
undetectable		 5igiA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_A_CVIA301_0
(REGULATORY PROTEIN
TETR)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		5 / 12 ALA A 193
SER A 186
GLU A 184
LEU A 182
ILE A 167
 None
 1.47A 5vlmA-6dzsA:
undetectable		 5vlmA-6dzsA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FK2_A_SORA302_0
(GALECTIN-3)		 6dzs HOMOSERINE
DEHYDROGENASE
(Mycolicibacteriu
m
hassiacum) 		4 / 4 ARG A 155
GLU A 255
GLU A 436
ARG A 269
 None
 1.22A 6fk2A-6dzsA:
undetectable		 6fk2A-6dzsA:
undetectable