SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6e0s'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_A_LEUA1894_0
(AMINOACYL-TRNA
SYNTHETASE)		 6e0s -
(-) 		4 / 8 ASP A  60
SER A  90
TYR A 267
HIS A 237
 None
None
None
ZN  A 302 (-4.3A)
 1.30A 2bteA-6e0sA:
undetectable		 2bteA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BTE_D_LEUD1893_0
(AMINOACYL-TRNA
SYNTHETASE)		 6e0s -
(-) 		4 / 8 ASP A  60
SER A  90
TYR A 267
HIS A 237
 None
None
None
ZN  A 302 (-4.3A)
 1.36A 2bteD-6e0sA:
undetectable		 2bteD-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2VMY_A_GLYA502_0
(SERINE
HYDROXYMETHYLTRANSFE
RASE)		 6e0s -
(-) 		4 / 7 SER A  90
HIS A 237
HIS A  91
TYR A 191
 None
ZN  A 302 (-4.3A)
ZN  A 301 (-3.3A)
None
 1.42A 2vmyA-6e0sA:
undetectable
2vmyB-6e0sA:
undetectable		 2vmyA-6e0sA:
undetectable
2vmyB-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZIF_B_SAMB298_0
(PUTATIVE
MODIFICATION
METHYLASE)		 6e0s -
(-) 		5 / 12 ALA A 113
SER A 101
ALA A  67
GLY A  61
LEU A  88
 None
 1.10A 2zifB-6e0sA:
undetectable		 2zifB-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TWP_D_SALD404_1
(ANTHRANILATE
PHOSPHORIBOSYLTRANSF
ERASE)		 6e0s -
(-) 		4 / 5 ASN A 196
ALA A 271
TYR A 267
ALA A 240
 None
 1.16A 3twpD-6e0sA:
undetectable		 3twpD-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6e0s -
(-) 		5 / 11 HIS A  91
HIS A  93
HIS A  96
HIS A 169
HIS A 237
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 302 (-4.2A)
ZN  A 301 (-3.4A)
ZN  A 302 (-4.3A)
 0.39A 5ayaA-6e0sA:
43.4		 5ayaA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6e0s -
(-) 		5 / 11 HIS A  91
HIS A  93
HIS A 169
SER A 194
HIS A 237
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
ZN  A 301 (-3.4A)
None
ZN  A 302 (-4.3A)
 0.84A 5ayaA-6e0sA:
43.4		 5ayaA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AYA_A_X8ZA307_1
(METALLO-BETA-LACTAMA
SE)		 6e0s -
(-) 		5 / 11 HIS A  91
HIS A  96
HIS A 169
HIS A 237
ARG A 274
 ZN  A 301 (-3.3A)
ZN  A 302 (-4.2A)
ZN  A 301 (-3.4A)
ZN  A 302 (-4.3A)
None
 0.70A 5ayaA-6e0sA:
43.4		 5ayaA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_A_X6XA202_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 6e0s -
(-) 		4 / 8 HIS A  91
GLY A 172
GLY A 173
HIS A  93
 ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-3.3A)
 0.76A 5f8yA-6e0sA:
undetectable		 5f8yA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5F8Y_B_X6XB201_1
(GALNAC/GAL-SPECIFIC
LECTIN)		 6e0s -
(-) 		4 / 8 HIS A  91
GLY A 172
GLY A 173
HIS A  93
 ZN  A 301 (-3.3A)
None
None
ZN  A 301 (-3.3A)
 0.75A 5f8yB-6e0sA:
undetectable		 5f8yB-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N9X_A_THRA601_0
(ADENYLATION DOMAIN)		 6e0s -
(-) 		4 / 7 ASP A 130
GLY A 173
GLY A 168
HIS A 169
 None
None
None
ZN  A 301 (-3.4A)
 0.98A 5n9xA-6e0sA:
undetectable		 5n9xA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NZW_A_9F2A1102_1
(DNA CROSS-LINK
REPAIR 1A PROTEIN)		 6e0s -
(-) 		5 / 10 HIS A  91
HIS A  93
ASP A  95
HIS A  96
HIS A 169
 ZN  A 301 (-3.3A)
ZN  A 301 (-3.3A)
None
ZN  A 302 (-4.2A)
ZN  A 301 (-3.4A)
 0.67A 5nzwA-6e0sA:
4.8		 5nzwA-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YW0_A_ACTA412_0
(UNCHARACTERIZED
PROTEIN KDOO)		 6e0s -
(-) 		3 / 3 LYS A  23
ASN A  25
SER A  63
 None
 1.24A 5yw0A-6e0sA:
undetectable		 5yw0A-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 6e0s -
(-) 		5 / 11 HIS A 169
HIS A  96
SER A  90
HIS A  93
PRO A 137
 ZN  A 301 (-3.4A)
ZN  A 302 (-4.2A)
None
ZN  A 301 (-3.3A)
None
 1.38A 5z0fA-6e0sA:
undetectable
5z0fB-6e0sA:
undetectable		 5z0fA-6e0sA:
undetectable
5z0fB-6e0sA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Z0F_B_DAHB98_0
(MELC
TYROSINASE)		 6e0s -
(-) 		5 / 11 HIS A 169
HIS A 237
HIS A  96
SER A  90
HIS A  93
 ZN  A 301 (-3.4A)
ZN  A 302 (-4.3A)
ZN  A 302 (-4.2A)
None
ZN  A 301 (-3.3A)
 1.49A 5z0fA-6e0sA:
undetectable
5z0fB-6e0sA:
undetectable		 5z0fA-6e0sA:
undetectable
5z0fB-6e0sA:
undetectable