SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6e12'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_1
(DNA TOPOISOMERASE II)		 6e12 -
(-) 		4 / 7 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.87A 1qzrA-6e12A:
0.5		 1qzrA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1QZR_B_CDXB901_2
(DNA TOPOISOMERASE II)		 6e12 -
(-) 		4 / 7 HIS A 120
TYR A 143
LEU A 147
GLN A 146
 OLA  A 301 (-3.8A)
None
OLA  A 301 ( 4.2A)
None
 0.88A 1qzrB-6e12A:
undetectable		 1qzrB-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2CDQ_A_SAMA1500_0
(ASPARTOKINASE)		 6e12 -
(-) 		4 / 8 ILE A  31
SER A  30
LEU A 156
GLU A 140
 OLA  A 301 (-4.6A)
None
None
OLA  A 301 (-3.4A)
 0.74A 2cdqA-6e12A:
undetectable		 2cdqA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OGY_A_C2FA3000_0
(5-METHYLTETRAHYDROFO
LATE CORRINOID/IRON
SULFUR PROTEIN
METHYLTRANSFERASE)		 6e12 -
(-) 		5 / 12 ILE A 122
LEU A  67
GLY A 194
GLN A  59
ILE A 195
 None
 1.18A 2ogyA-6e12A:
undetectable		 2ogyA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LUH_A_ACTA609_0
(SERUM ALBUMIN)		 6e12 -
(-) 		4 / 4 ALA A  60
HIS A 115
PHE A 111
LEU A  51
 None
 1.45A 4luhA-6e12A:
1.3		 4luhA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_A_BZMA301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.18A 5nnaA-6e12A:
undetectable		 5nnaA-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_B_BZMB301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.19A 5nnaB-6e12A:
undetectable		 5nnaB-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5NNA_C_BZMC301_0
(ISATIN HYDROLASE A)		 6e12 -
(-) 		5 / 12 ILE A  31
LEU A 156
HIS A 120
SER A  23
GLY A  26
 OLA  A 301 (-4.6A)
None
OLA  A 301 (-3.8A)
None
OLA  A 301 (-3.9A)
 1.20A 5nnaC-6e12A:
undetectable		 5nnaC-6e12A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5OEX_A_CUA604_0
(THIOCYANATE
DEHYDROGENASE)		 6e12 -
(-) 		3 / 3 HIS A  90
HIS A 124
HIS A 120
 None
None
OLA  A 301 (-3.8A)
 0.99A 5oexA-6e12A:
undetectable		 5oexA-6e12A:
undetectable