SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6e85'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FML_B_RTLB501_0
(RETINOL DEHYDRATASE)		 6e85 -
(-) 		5 / 12 LEU A  43
LEU A  47
HIS A 298
LEU A  24
ILE A  73
 None
 1.25A 1fmlB-6e85A:
undetectable		 1fmlB-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1M2Z_D_DEXD401_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.03A 1m2zD-6e85A:
undetectable		 1m2zD-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_A_BEZA501_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6e85 -
(-) 		4 / 7 PHE A 251
ALA A 207
TYR A 266
PRO A 247
 FMT  A 402 (-4.8A)
None
None
None
 0.99A 1oniA-6e85A:
undetectable
1oniB-6e85A:
2.5		 1oniA-6e85A:
undetectable
1oniB-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ONI_I_BEZI517_0
(14.5 KDA
TRANSLATIONAL
INHIBITOR PROTEIN)		 6e85 -
(-) 		4 / 7 TYR A 266
PRO A 247
PHE A 251
ALA A 207
 None
None
FMT  A 402 (-4.8A)
None
 1.05A 1oniG-6e85A:
2.5
1oniI-6e85A:
undetectable		 1oniG-6e85A:
undetectable
1oniI-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_B_DEXB2999_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.10A 1p93B-6e85A:
undetectable		 1p93B-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.09A 1p93D-6e85A:
undetectable		 1p93D-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG7_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6e85 -
(-) 		5 / 12 ALA A 116
ALA A 117
SER A 318
ILE A 319
LEU A  24
 None
 1.12A 1rg7A-6e85A:
undetectable		 1rg7A-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2D0K_B_FOLB2161_0
(DIHYDROFOLATE
REDUCTASE)		 6e85 -
(-) 		6 / 12 ALA A 114
PHE A 291
THR A   8
ILE A 103
LEU A 142
ILE A 118
 None
 1.40A 2d0kB-6e85A:
undetectable		 2d0kB-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3IV6_C_SAMC301_0
(PUTATIVE
ZN-DEPENDENT ALCOHOL
DEHYDROGENASE)		 6e85 -
(-) 		5 / 12 PRO A  83
GLY A  38
ILE A  73
ARG A  45
LEU A  43
 None
 1.08A 3iv6C-6e85A:
undetectable		 3iv6C-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNE_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.03A 3mneA-6e85A:
undetectable		 3mneA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNO_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.05A 3mnoA-6e85A:
undetectable		 3mnoA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3MNP_A_DEXA784_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.07A 3mnpA-6e85A:
undetectable		 3mnpA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_C_STRC601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6e85 -
(-) 		5 / 12 LEU A 178
ILE A 226
GLY A 208
ALA A 207
VAL A 231
 None
 1.03A 4nkxC-6e85A:
undetectable		 4nkxC-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4NKX_D_STRD601_1
(STEROID
17-ALPHA-HYDROXYLASE
/17,20 LYASE)		 6e85 -
(-) 		5 / 12 LEU A 178
ILE A 226
GLY A 208
ALA A 207
VAL A 231
 None
 1.04A 4nkxD-6e85A:
undetectable		 4nkxD-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_A_HCYA900_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.11A 4p6xA-6e85A:
undetectable		 4p6xA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_E_HCYE900_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.09A 4p6xE-6e85A:
undetectable		 4p6xE-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_G_HCYG900_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.15A 4p6xG-6e85A:
undetectable		 4p6xG-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_I_HCYI900_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.13A 4p6xI-6e85A:
undetectable		 4p6xI-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P6X_K_HCYK900_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.11A 4p6xK-6e85A:
undetectable		 4p6xK-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4UDC_A_DEXA1778_1
(GLUCOCORTICOID
RECEPTOR)		 6e85 -
(-) 		5 / 12 GLY A 288
ARG A 182
THR A 107
ILE A 118
PHE A 291
 None
 1.02A 4udcA-6e85A:
undetectable		 4udcA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5FA8_A_SAMA301_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE,
PUTATIVE)		 6e85 -
(-) 		5 / 12 GLY A  14
GLY A  16
ILE A  46
PHE A 302
LEU A  98
 None
 1.13A 5fa8A-6e85A:
undetectable		 5fa8A-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VEU_A_RITA602_1
(CYTOCHROME P450 3A5)		 6e85 -
(-) 		5 / 12 ARG A  45
ILE A  20
ALA A 121
ALA A  95
GLY A  89
 None
 1.06A 5veuA-6e85A:
undetectable		 5veuA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5XXI_A_LSNA503_1
(CYTOCHROME P450 2C9)		 6e85 -
(-) 		5 / 12 PHE A 100
LEU A  98
LEU A 109
THR A 107
LEU A 145
 None
 1.11A 5xxiA-6e85A:
undetectable		 5xxiA-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_C_CHDC401_0
(BILE SALT HYDROLASE)		 6e85 -
(-) 		4 / 8 ILE A  15
LEU A  98
ALA A  95
LEU A  86
 None
 0.67A 5y7pC-6e85A:
undetectable		 5y7pC-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5Y7P_E_CHDE401_0
(BILE SALT HYDROLASE)		 6e85 -
(-) 		4 / 8 ILE A  15
LEU A  98
ALA A  95
LEU A  86
 None
 0.67A 5y7pE-6e85A:
undetectable		 5y7pE-6e85A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NM4_A_SAMA402_0
(HISTONE-LYSINE
N-METHYLTRANSFERASE
PRDM9)		 6e85 -
(-) 		4 / 7 ALA A  95
GLY A  96
LEU A 128
GLY A  16
 None
 0.86A 6nm4A-6e85A:
undetectable		 6nm4A-6e85A:
undetectable