SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6egt'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1FDU_C_ESTC353_1
(17-BETA-HYDROXYSTERO
ID DEHYDROGENASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 12 SER A 725
GLY A 724
LEU A 694
GLY A 727
VAL A1023
 None
 1.19A 1fduC-6egtA:
undetectable		 1fduC-6egtA:
19.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P93_D_DEXD4999_2
(GLUCOCORTICOID
RECEPTOR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 5 LEU A1060
MET A1098
LEU A1108
GLN A1084
 None
 1.46A 1p93D-6egtA:
undetectable		 1p93D-6egtA:
20.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_A_VIBA501_1
(YKOF)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 8 SER A1003
ILE A1071
THR A 984
THR A 989
 None
 0.87A 1sbrA-6egtA:
undetectable		 1sbrA-6egtA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1SBR_B_VIBB503_1
(YKOF)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 7 SER A1003
ILE A1071
THR A 984
THR A 989
 None
 0.90A 1sbrB-6egtA:
undetectable		 1sbrB-6egtA:
18.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1TYR_B_9CRB130_1
(TRANSTHYRETIN)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 7 LEU A1011
THR A 883
LEU A 890
SER A 879
 None
 1.00A 1tyrB-6egtA:
undetectable		 1tyrB-6egtA:
14.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_A_SAMA417_0
(L-LYSINE
2,3-AMINOMUTASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 11 HIS A 857
THR A 860
GLN A1000
ASP A 874
LEU A 875
 None
 1.39A 2a5hA-6egtA:
undetectable		 2a5hA-6egtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2A5H_D_SAMD417_0
(L-LYSINE
2,3-AMINOMUTASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 12 HIS A 857
THR A 860
GLN A1000
ASP A 874
LEU A 875
 None
 1.40A 2a5hD-6egtA:
undetectable		 2a5hD-6egtA:
20.51
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2AOH_C_FRDC305_1
(POL POLYPROTEIN
PEPTIDE INHIBITOR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 5 LEU A1034
ASP A1081
GLY A1078
ALA A1032
 NAG  A1302 ( 4.4A)
NAG  A1302 (-3.5A)
FUL  A1304 ( 4.2A)
None
 0.97A 2aohA-6egtA:
undetectable		 2aohA-6egtA:
12.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QMZ_B_LDPB502_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 5 PHE A 990
PHE A 903
TRP A 855
GLY A 899
 None
 1.36A 2qmzA-6egtA:
undetectable
2qmzB-6egtA:
undetectable		 2qmzA-6egtA:
16.38
2qmzB-6egtA:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2W9S_E_TOPE1160_1
(DIHYDROFOLATE
REDUCTASE TYPE 1
FROM TN4003)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 8 ILE A 721
ALA A 723
LEU A 859
ILE A 747
 None
 0.80A 2w9sE-6egtA:
undetectable		 2w9sE-6egtA:
13.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2Y00_B_Y00B601_2
(BETA-1 ADRENERGIC
RECEPTOR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 VAL A 803
ASN A 812
TRP A 791
 None
 0.66A 2y00B-6egtA:
undetectable		 2y00B-6egtA:
19.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BOG_D_DHID8_0
(6.5 KDA GLYCINE-RICH
ANTIFREEZE PROTEIN)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 4 SER A 725
GLY A 724
GLY A 727
GLY A1058
 None
 0.90A 3bogB-6egtA:
undetectable
3bogD-6egtA:
undetectable		 3bogB-6egtA:
undetectable
3bogD-6egtA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3DLC_A_SAMA220_0
(PUTATIVE
S-ADENOSYL-L-METHION
INE-DEPENDENT
METHYLTRANSFERASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 12 GLY A1058
SER A1061
ASP A1102
VAL A1027
SER A1075
 None
 1.26A 3dlcA-6egtA:
undetectable		 3dlcA-6egtA:
16.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EEO_A_SAMA328_1
(MODIFICATION
METHYLASE HHAI)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 GLU A 782
SER A 774
VAL A1133
 None
 0.80A 3eeoA-6egtA:
undetectable		 3eeoA-6egtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3KP6_B_SALB3001_1
(TRANSCRIPTIONAL
REGULATOR TCAR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 8 LYS A 813
ASN A 812
HIS A 836
ILE A 954
 None
 1.30A 3kp6A-6egtA:
undetectable
3kp6B-6egtA:
undetectable		 3kp6A-6egtA:
14.29
3kp6B-6egtA:
14.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3LW5_B_PQNB5002_1
(PHOTOSYSTEM I P700
CHLOROPHYLL A
APOPROTEIN A2)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 10 ILE A1085
SER A 908
ALA A 992
LEU A 981
ALA A 914
 None
 1.34A 3lw5B-6egtA:
undetectable		 3lw5B-6egtA:
20.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3ROD_A_NCAA302_0
(NICOTINAMIDE
N-METHYLTRANSFERASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 8 LEU A 890
ASP A 893
ALA A1009
SER A 752
 None
 1.11A 3rodA-6egtA:
undetectable		 3rodA-6egtA:
19.40
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3SI7_A_ACTA5_0
(CYSTIC FIBROSIS
TRANSMEMBRANE
CONDUCTANCE
REGULATOR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 LYS A 858
SER A 993
GLN A1000
 None
 1.06A 3si7A-6egtA:
undetectable		 3si7A-6egtA:
20.86
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WDM_C_ADNC301_1
(4-PHOSPHOPANTOATE--B
ETA-ALANINE LIGASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 9 ALA A1009
GLY A 724
LEU A 861
LEU A 694
ILE A 747
 None
 1.17A 3wdmC-6egtA:
undetectable		 3wdmC-6egtA:
18.80
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MBS_A_MRVA1101_2
(CHIMERA PROTEIN OF
C-C CHEMOKINE
RECEPTOR TYPE 5 AND
RUBREDOXIN)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 7 GLN A 741
THR A 742
THR A 718
MET A1014
 None
 1.01A 4mbsA-6egtA:
undetectable		 4mbsA-6egtA:
20.11
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4O8Z_A_BBIA402_1
(NAD-DEPENDENT
PROTEIN DEACETYLASE
SIRTUIN-3,
MITOCHONDRIAL)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 5 PHE A 905
PHE A 850
LEU A 929
PRO A 972
 None
 1.34A 4o8zA-6egtA:
undetectable		 4o8zA-6egtA:
20.41
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OT2_A_ACTA605_0
(SERUM ALBUMIN)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 LYS A 994
LYS A1004
ALA A 991
 None
 1.44A 4ot2A-6egtA:
undetectable		 4ot2A-6egtA:
20.44
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4XR4_B_AG2B511_1
(HOMOSPERMIDINE
SYNTHASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 VAL A 999
PHE A 903
ARG A 985
 None
 0.81A 4xr4B-6egtA:
undetectable		 4xr4B-6egtA:
22.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5JQ7_B_T0RB705_2
(ENVELOPE
GLYCOPROTEIN 2)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 7 THR A 984
THR A 989
ASP A 987
LEU A1114
 None
 1.09A 5jq7B-6egtA:
undetectable		 5jq7B-6egtA:
15.12
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5N0S_B_SAMB501_0
(PEPTIDE
N-METHYLTRANSFERASE)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		5 / 12 ILE A1052
VAL A 726
SER A1075
TYR A1099
ALA A1031
 None
 1.15A 5n0sB-6egtA:
undetectable		 5n0sB-6egtA:
21.81
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TE8_B_08JB602_1
(CYTOCHROME P450 3A4)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 8 LEU A 892
ALA A 894
ALA A 877
LEU A 890
 None
 0.81A 5te8B-6egtA:
undetectable		 5te8B-6egtA:
21.30
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5VLM_C_CVIC301_1
(REGULATORY PROTEIN
TETR)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		4 / 7 GLY A1058
ILE A1052
GLN A1084
TYR A1099
 None
 1.14A 5vlmC-6egtA:
undetectable		 5vlmC-6egtA:
13.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA819_0
(GEPHYRIN)		 6egt GLYCOPROTEIN
(Rift
Valley
fever
phlebovirus) 		3 / 3 ARG A 933
GLY A 930
GLU A 931
 None
 0.57A 6fgdA-6egtA:
undetectable		 6fgdA-6egtA:
21.73