SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehc'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1LQT_B_ACTB1873_0
(FPRA)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		3 / 3 ASP A 105
ASP A 133
LYS A 151
 None
 1.15A 1lqtB-6ehcA:
undetectable		 1lqtB-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2TSR_C_D16C509_1
(THYMIDYLATE SYNTHASE)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		5 / 10 GLU A 212
ILE A 129
ASP A 105
GLY A 106
TYR A  87
 None
 1.46A 2tsrC-6ehcA:
undetectable		 2tsrC-6ehcA:
13.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		5 / 12 GLY A 143
GLY A 203
ALA A 202
GLY A 149
LEU A 148
 None
 0.79A 3hs6B-6ehcA:
undetectable		 3hs6B-6ehcA:
9.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_A_SAMA300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		5 / 12 LEU A 108
ALA A 189
GLY A 201
GLY A 203
LEU A 187
 None
 1.12A 3ou7A-6ehcA:
undetectable		 3ou7A-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3OU7_D_SAMD300_0
(SAM-DEPENDENT
METHYLTRANSFERASE)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		5 / 12 LEU A 108
ALA A 189
GLY A 201
GLY A 203
LEU A 187
 None
 1.14A 3ou7D-6ehcA:
undetectable		 3ou7D-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4IJI_F_BEZF501_0
(GLUTATHIONE
S-TRANSFERASE-LIKE
PROTEIN YIBF)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		4 / 8 SER A  43
ARG A 317
TYR A 290
ARG A  27
 None
 1.10A 4ijiF-6ehcA:
undetectable		 4ijiF-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		4 / 8 ARG A  86
ARG A  44
ARG A  31
ASP A 116
 None
 1.25A 4kr4C-6ehcA:
26.9		 4kr4C-6ehcA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KR4_C_AICC401_1
(OUTER MEMBRANE
PROTEIN F)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		4 / 8 TYR A 282
ARG A 288
ARG A 317
ASP A 116
 None
 1.26A 4kr4C-6ehcA:
26.9		 4kr4C-6ehcA:
13.49
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4X5I_A_FOLA201_1
(DIHYDROFOLATE
REDUCTASE)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		3 / 3 ASP A 113
ARG A  44
ARG A  86
 None
 0.87A 4x5iA-6ehcA:
undetectable		 4x5iA-6ehcA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z2E_H_TR6H101_1
(DNA GYRASE SUBUNIT A
DNA GYRASE SUBUNIT B
SYMMETRIZED E-SITE
DNA)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		3 / 5 GLY A  63
GLY A  91
GLU A  98
 None
 0.45A 4z2eA-6ehcA:
undetectable
4z2eD-6ehcA:
undetectable		 4z2eA-6ehcA:
10.06
4z2eD-6ehcA:
16.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5W7B_A_PA1A206_1
(ACYLOXYACYL
HYDROLASE SMALL
SUBUNIT
ACYLOXYACYL
HYDROLASE LARGE
SUBUNIT)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		4 / 4 TYR A 154
GLY A 181
ASN A 180
ARG A 155
 None
 1.37A 5w7bA-6ehcA:
undetectable
5w7bC-6ehcA:
undetectable		 5w7bA-6ehcA:
22.22
5w7bC-6ehcA:
22.83
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X6Y_A_SAMA902_1
(MRNA CAPPING ENZYME
P5)		 6ehc OUTER MEMBRANE
PROTEIN U
(Vibrio
cholerae) 		3 / 3 TYR A 185
ASP A 183
ASP A 206
 None
 0.75A 5x6yA-6ehcA:
undetectable		 5x6yA-6ehcA:
undetectable