SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehe'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1ESW_A_ACRA652_1
(AMYLOMALTASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		4 / 6 TYR A  95
GLY A 107
TYR A 215
SER A 100
 None
 0.79A 1eswA-6eheA:
undetectable		 1eswA-6eheA:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HTT_D_HISD450_0
(HISTIDYL-TRNA
SYNTHETASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		5 / 12 GLU A 150
LEU A 108
TYR A 215
GLY A 111
ALA A 116
 None
 1.17A 1httD-6eheA:
undetectable		 1httD-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1WOP_A_FFOA2887_1
(AMINOMETHYLTRANSFERA
SE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		3 / 3 ASP A  93
GLU A  57
ARG A 282
 C8E  A 407 (-3.8A)
None
ACT  A 410 ( 4.6A)
 0.88A 1wopA-6eheA:
undetectable		 1wopA-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QE6_B_SAMB400_0
(UNCHARACTERIZED
PROTEIN TFU_2867)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		5 / 12 ALA A  97
GLY A 107
ILE A 233
VAL A 254
GLY A 104
 None
 0.94A 2qe6B-6eheA:
undetectable		 2qe6B-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3V4T_H_ACTH504_0
(UDP-N-ACETYLGLUCOSAM
INE
1-CARBOXYVINYLTRANSF
ERASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		3 / 3 LYS A  55
GLU A  57
TRP A  88
 None
 0.94A 3v4tH-6eheA:
undetectable		 3v4tH-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_G_MTXG301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		5 / 9 PHE A 302
GLY A 290
GLY A 288
LEU A 268
GLU A 252
 None
 1.32A 4l8wG-6eheA:
undetectable		 4l8wG-6eheA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L8W_I_MTXI301_1
(GAMMA-GLUTAMYL
HYDROLASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		5 / 9 PHE A 302
GLY A 290
GLY A 288
LEU A 268
GLU A 252
 None
 1.34A 4l8wI-6eheA:
undetectable		 4l8wI-6eheA:
15.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4P7N_A_GCSA702_1
(POLY-BETA-1,6-N-ACET
YL-D-GLUCOSAMINE
N-DEACETYLASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		3 / 3 ASP A  92
TYR A  95
TRP A  88
 None
 0.81A 4p7nA-6eheA:
undetectable		 4p7nA-6eheA:
14.25
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4R29_B_SAMB301_0
(UNCHARACTERIZED
PROTEIN)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		5 / 12 ARG A 307
SER A  35
GLY A  34
GLU A 286
GLY A 305
 MG  A 409 (-3.5A)
None
None
None
None
 1.26A 4r29B-6eheA:
undetectable		 4r29B-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4YSH_B_GLYB401_0
(GLYCINE OXIDASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		4 / 6 LYS A 123
GLY A 136
TYR A 137
ALA A 149
 None
C8E  A 404 (-4.5A)
None
C8E  A 404 (-3.6A)
 1.32A 4yshB-6eheA:
undetectable		 4yshB-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_I_BEZI1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		3 / 3 SER A 100
TYR A  99
TYR A 248
 None
 0.53A 5lakA-6eheA:
undetectable
5lakI-6eheA:
undetectable		 5lakA-6eheA:
undetectable
5lakI-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LAK_J_BEZJ1_0
(3CL PROTEASE
BEZ-TYR-TYR-ASN-ECC
PEPTIDE INHIBITOR)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		3 / 3 SER A 100
TYR A  99
TYR A 248
 None
 0.56A 5lakC-6eheA:
undetectable
5lakJ-6eheA:
undetectable		 5lakC-6eheA:
undetectable
5lakJ-6eheA:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5LRB_A_ACRA1003_1
(ALPHA-1,4 GLUCAN
PHOSPHORYLASE)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		4 / 6 GLU A 286
THR A 238
TYR A 248
PHE A 102
 None
 1.14A 5lrbA-6eheA:
undetectable		 5lrbA-6eheA:
7.66
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6MN5_E_LLLE301_0
(AMINOGLYCOSIDE
N(3)-ACETYLTRANSFERA
SE, AAC(3)-IVA)		 6ehe OMPT PROTEIN
(Vibrio
cholerae) 		4 / 7 ASP A  98
TYR A 270
GLU A 286
GLU A 274
 None
None
None
ACT  A 410 ( 4.6A)
 1.29A 6mn5E-6eheA:
undetectable		 6mn5E-6eheA:
18.82