SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehr'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3B7P_C_SPMC503_1 (SPERMIDINE SYNTHASE)	6ehr	RAS-RELATED GTP-BINDING PROTEIN A RAS-RELATED GTP-BINDING PROTEIN C (Homo sapiens)	5 / 12	GLN F 218 TYR G 299 ASP F 201 SER F 232 ILE F 231	None	1.47A	3b7pC-6ehrF: undetectable	3b7pC-6ehrF: 18.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3TBG_D_RTZD2_1 (CYTOCHROME P450 2D6)	6ehr	RAS-RELATED GTP-BINDING PROTEIN C (Homo sapiens)	5 / 9	PHE G 367 LEU G 335 VAL G 331 LEU G 243 ILE G 363	None	1.10A	3tbgD-6ehrG: undetectable	3tbgD-6ehrG: 16.60
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4A97_B_ZPCB1318_1 (CYS-LOOP LIGAND-GATED ION CHANNEL)	6ehr	RAS-RELATED GTP-BINDING PROTEIN A (Homo sapiens)	5 / 12	ILE F 198 GLU F 188 HIS F 216 VAL F 274 PHE F 297	None	1.49A	4a97A-6ehrF: undetectable 4a97B-6ehrF: undetectable	4a97A-6ehrF: 18.89 4a97B-6ehrF: 18.89
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4F3T_A_IPHA902_0 (PROTEIN ARGONAUTE-2)	6ehr	RAS-RELATED GTP-BINDING PROTEIN C (Homo sapiens)	4 / 6	LEU G 261 TYR G 269 LEU G 247 GLU G 244	None	1.07A	4f3tA-6ehrG: undetectable	4f3tA-6ehrG: 12.13

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["3B7P_C_SPMC503_1","SPERMIDINE SYNTHASE","6ehr","RAS-RELATED GTP-BINDING PROTEIN A;RAS-RELATED GTP-BINDING PROTEIN C","Homo sapiens",5,"GLN F 218;TYR G 299;ASP F 201;SER F 232;ILE F 231","None","1.47A","3b7pC-6ehrF:undetectable","3b7pC-6ehrF:18.28"],["3TBG_D_RTZD2_1","CYTOCHROME P450 2D6","6ehr","RAS-RELATED GTP-BINDING PROTEIN C","Homo sapiens",5,"PHE G 367;LEU G 335;VAL G 331;LEU G 243;ILE G 363","None","1.10A","3tbgD-6ehrG:undetectable","3tbgD-6ehrG:16.60"],["4A97_B_ZPCB1318_1","CYS-LOOP LIGAND-GATED ION CHANNEL;CYS-LOOP LIGAND-GATED ION CHANNEL","6ehr","RAS-RELATED GTP-BINDING PROTEIN A","Homo sapiens",5,"ILE F 198;GLU F 188;HIS F 216;VAL F 274;PHE F 297","None","1.49A","4a97A-6ehrF:undetectable;4a97B-6ehrF:undetectable","4a97A-6ehrF:18.89;4a97B-6ehrF:18.89"],["4F3T_A_IPHA902_0","PROTEIN ARGONAUTE-2","6ehr","RAS-RELATED GTP-BINDING PROTEIN C","Homo sapiens",4,"LEU G 261;TYR G 269;LEU G 247;GLU G 244","None","1.07A","4f3tA-6ehrG:undetectable","4f3tA-6ehrG:12.13"]]