SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehs'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AO8_A_MTXA170_2
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 TRP L  32
LEU L  17
ARG L 538
THR L 525
 None
 1.39A 1ao8A-6ehsL:
undetectable		 1ao8A-6ehsL:
17.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1AV2_D_DVAD6_0
(GRAMICIDIN A)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 TRP L 504
ALA L 550
VAL L 499
 None
CSO  L 546 ( 3.5A)
None
 0.99A 1av2C-6ehsL:
undetectable
1av2D-6ehsL:
undetectable		 1av2C-6ehsL:
undetectable
1av2D-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D4F_B_ADNB602_2
(S-ADENOSYLHOMOCYSTEI
NE HYDROLASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 THR L 100
THR L 101
THR L 262
HIS L 107
 None
 1.28A 1d4fB-6ehsL:
undetectable		 1d4fB-6ehsL:
10.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
ILE L  94
THR L 212
 None
 1.14A 1dhiA-6ehsL:
undetectable		 1dhiA-6ehsL:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHI_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
LEU L 439
THR L 212
 None
 1.08A 1dhiA-6ehsL:
undetectable		 1dhiA-6ehsL:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
ILE L  94
THR L 212
 None
 1.12A 1dhjA-6ehsL:
undetectable		 1dhjA-6ehsL:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DHJ_B_MTXB361_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.02A 1dhjB-6ehsL:
undetectable		 1dhjB-6ehsL:
19.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
ILE L  94
THR L 212
 None
 1.14A 1drbA-6ehsL:
undetectable		 1drbA-6ehsL:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DRB_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
LEU L 439
THR L 212
 None
 1.06A 1drbA-6ehsL:
undetectable		 1drbA-6ehsL:
17.31
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JOL_B_FFOB361_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.08A 1jolB-6ehsL:
undetectable		 1jolB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1JQD_A_HSMA600_1
(HISTAMINE
N-METHYLTRANSFERASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 7 PHE L 148
GLN L 193
VAL L 257
ASN L 143
 None
 1.39A 1jqdA-6ehsL:
undetectable		 1jqdA-6ehsL:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1N2X_A_SAMA401_0
(S-ADENOSYL-METHYLTRA
NSFERASE MRAW)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 HIS L 318
GLY L 473
VAL L 223
VAL L  84
GLN L  89
 None
 1.23A 1n2xA-6ehsL:
undetectable		 1n2xA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  23
ILE L  13
ILE L 540
LEU L 522
VAL L  28
 None
 0.89A 1oipA-6ehsL:
undetectable		 1oipA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1OIP_A_VIVA1278_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 LEU L 534
ILE L  23
ILE L 540
LEU L 522
VAL L  28
 None
 0.87A 1oipA-6ehsL:
undetectable		 1oipA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC685_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.91A 1p7lD-6ehsL:
undetectable		 1p7lD-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P7L_C_SAMC885_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.91A 1p7lC-6ehsL:
undetectable		 1p7lC-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RB3_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 ILE L  95
ALA L 206
ILE L 247
ILE L  94
THR L 212
 None
 1.18A 1rb3A-6ehsL:
undetectable		 1rb3A-6ehsL:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_A_SAMA385_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.93A 1rg9B-6ehsL:
undetectable		 1rg9B-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_B_SAMB485_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.93A 1rg9A-6ehsL:
undetectable		 1rg9A-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC585_1
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.92A 1rg9D-6ehsL:
undetectable		 1rg9D-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RG9_C_SAMC685_0
(S-ADENOSYLMETHIONINE
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ALA L 130
GLU L 182
ASP L 118
ILE L 155
 None
 0.92A 1rg9C-6ehsL:
undetectable		 1rg9C-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1XDK_B_9CRB600_1
(RETINOIC ACID
RECEPTOR, BETA)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ALA L  97
LEU L 208
ILE L 243
ILE L 247
LEU L 446
 None
 0.79A 1xdkB-6ehsL:
undetectable		 1xdkB-6ehsL:
11.63
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z11_D_8MOD501_0
(CYTOCHROME P450,
FAMILY 2, SUBFAMILY
A, POLYPEPTIDE 6)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 PHE L 297
VAL L 285
GLY L 473
ILE L 324
LEU L 323
 None
 1.10A 1z11D-6ehsL:
undetectable		 1z11D-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1Z2B_C_VLBC800_2
(TUBULIN ALPHA CHAIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 PRO L 533
VAL L 527
VAL L  28
ILE L   5
 None
 1.09A 1z2bC-6ehsL:
undetectable		 1z2bC-6ehsL:
10.22
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AV6_A_SAMA1_0
(DNA
(CYTOSINE-5)-METHYLT
RANSFERASE 1)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 GLY L 209
LEU L 208
LEU L 435
ASN L 202
ALA L 206
 None
 1.05A 3av6A-6ehsL:
undetectable		 3av6A-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BPX_B_SALB258_1
(TRANSCRIPTIONAL
REGULATOR)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 ALA L  76
LEU L  80
PRO L 461
GLY L 221
ARG L  92
 None
 1.29A 3bpxA-6ehsL:
0.0
3bpxB-6ehsL:
0.5		 3bpxA-6ehsL:
21.13
3bpxB-6ehsL:
21.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 GLY L 378
SER L 502
THR L 503
SER L 483
ALA L 477
 None
FCO  L 601 (-2.8A)
None
None
FCO  L 601 (-3.6A)
 1.07A 3d91A-6ehsL:
undetectable		 3d91A-6ehsL:
12.13
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3L8L_B_DVAB6_0
(GRAMICIDIN D)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 TRP L 504
ALA L 550
VAL L 499
 None
CSO  L 546 ( 3.5A)
None
 1.00A 3l8lA-6ehsL:
undetectable
3l8lB-6ehsL:
undetectable		 3l8lA-6ehsL:
undetectable
3l8lB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3N0H_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 ILE L 404
ALA L 266
ILE L 186
LEU L 134
VAL L 260
 None
 1.09A 3n0hA-6ehsL:
undetectable		 3n0hA-6ehsL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_A_AICA375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 GLY L 276
LEU L 422
SER L 542
LEU L 380
LEU L 273
 None
 1.20A 3ndvA-6ehsL:
undetectable
3ndvB-6ehsL:
undetectable		 3ndvA-6ehsL:
13.39
3ndvB-6ehsL:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_B_AICB376_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 LEU L 273
GLY L 276
LEU L 422
SER L 542
LEU L 380
 None
 1.20A 3ndvA-6ehsL:
undetectable
3ndvB-6ehsL:
undetectable		 3ndvA-6ehsL:
13.39
3ndvB-6ehsL:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_C_AICC375_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 GLY L 276
LEU L 422
SER L 542
LEU L 380
LEU L 273
 None
 1.19A 3ndvC-6ehsL:
undetectable
3ndvD-6ehsL:
undetectable		 3ndvC-6ehsL:
13.39
3ndvD-6ehsL:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NDV_D_AICD374_1
(BETA-PEPTIDYL
AMINOPEPTIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 LEU L 273
GLY L 276
LEU L 422
SER L 542
LEU L 380
 None
 1.20A 3ndvC-6ehsL:
undetectable
3ndvD-6ehsL:
undetectable		 3ndvC-6ehsL:
13.39
3ndvD-6ehsL:
13.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3NXU_A_RITA600_1
(CYTOCHROME P450 3A4)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 265
ALA L 113
ILE L 119
ALA L 122
GLY L 173
 None
 0.99A 3nxuA-6ehsL:
undetectable		 3nxuA-6ehsL:
9.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3S3V_A_TOPA187_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 404
ALA L 266
ILE L 186
LEU L 134
VAL L 260
 None
 1.07A 3s3vA-6ehsL:
undetectable		 3s3vA-6ehsL:
16.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UBO_B_ADNB353_1
(ADENOSINE KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.00A 3uboB-6ehsL:
undetectable		 3uboB-6ehsL:
13.90
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VW1_D_CVID301_0
(PUTATIVE REGULATORY
PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 LEU L 422
THR L 525
ILE L 265
ALA L 113
ASP L 115
 None
 1.26A 3vw1D-6ehsL:
undetectable		 3vw1D-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VYW_A_SAMA501_0
(MNMC2)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 TYR L 322
GLY L 302
GLU L 305
ALA L 381
PHE L 370
 None
 1.16A 3vywA-6ehsL:
undetectable		 3vywA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_B_W9TB501_1
(HEMOLYTIC LECTIN
CEL-III)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 ASP L 354
SER L 357
GLY L 360
TRP L 335
 None
 1.10A 3w9tB-6ehsL:
undetectable		 3w9tB-6ehsL:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_C_W9TC1003_1
(HEMOLYTIC LECTIN
CEL-III)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 ASP L 354
SER L 357
GLY L 360
TRP L 335
 None
 1.10A 3w9tC-6ehsL:
undetectable		 3w9tC-6ehsL:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_D_W9TD501_1
(HEMOLYTIC LECTIN
CEL-III)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 ASP L 354
SER L 357
GLY L 360
TRP L 335
 None
 1.10A 3w9tD-6ehsL:
undetectable		 3w9tD-6ehsL:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W9T_F_W9TF501_1
(HEMOLYTIC LECTIN
CEL-III)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 ASP L 354
SER L 357
GLY L 360
TRP L 335
 None
 1.10A 3w9tF-6ehsL:
0.0		 3w9tF-6ehsL:
9.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WZD_A_LEVA1201_2
(VASCULAR ENDOTHELIAL
GROWTH FACTOR
RECEPTOR 2)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 ILE L 401
VAL L 137
LEU L 134
ASP L 261
 None
 1.15A 3wzdA-6ehsL:
undetectable		 3wzdA-6ehsL:
16.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4DFR_A_MTXA161_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
SER L 245
ILE L 247
LEU L 439
 None
 1.06A 4dfrA-6ehsL:
undetectable		 4dfrA-6ehsL:
18.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4E3A_A_ADNA500_1
(SUGAR KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.01A 4e3aA-6ehsL:
undetectable		 4e3aA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4F4D_A_CHDA505_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 7 ILE L  91
ARG L  92
VAL L  73
MET L  55
 None
 1.39A 4f4dA-6ehsL:
undetectable		 4f4dA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FHB_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		6 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
ILE L  94
THR L 212
 None
 1.18A 4fhbA-6ehsL:
undetectable		 4fhbA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4G8Z_X_TOPX301_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 ILE L  95
ALA L 206
SER L 245
ILE L  94
THR L 212
 None
 1.27A 4g8zX-6ehsL:
undetectable		 4g8zX-6ehsL:
16.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4II8_A_010A210_0
(LYSOZYME C)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 7 GLU L 535
ASP L 529
ASN L 531
ILE L   5
 None
 1.25A 4ii8A-6ehsL:
undetectable		 4ii8A-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4JKU_B_ADNB500_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.98A 4jkuB-6ehsL:
undetectable		 4jkuB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_A_ADNA401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4k8pA-6ehsL:
undetectable		 4k8pA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8P_B_ADNB401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.00A 4k8pB-6ehsL:
undetectable		 4k8pB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_A_ADNA401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.00A 4k8tA-6ehsL:
undetectable		 4k8tA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K8T_B_ADNB401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.01A 4k8tB-6ehsL:
undetectable		 4k8tB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_A_ADNA401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4k93A-6ehsL:
undetectable		 4k93A-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K93_B_ADNB402_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4k93B-6ehsL:
undetectable		 4k93B-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_A_ADNA401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4k9cA-6ehsL:
undetectable		 4k9cA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9C_B_ADNB401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.98A 4k9cB-6ehsL:
undetectable		 4k9cB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_A_ADNA401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.98A 4k9iA-6ehsL:
undetectable		 4k9iA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K9I_B_ADNB401_1
(SUGAR KINASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4k9iB-6ehsL:
undetectable		 4k9iB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.98A 4kadA-6ehsL:
undetectable		 4kadA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KAD_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4kadB-6ehsL:
undetectable		 4kadB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4KFJ_B_FOLB202_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 404
ALA L 266
ILE L 186
LEU L 134
VAL L 260
 None
 1.07A 4kfjB-6ehsL:
undetectable		 4kfjB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L9Q_A_9TPA601_1
(SERUM ALBUMIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 LEU L 235
ARG L 239
ALA L  98
TYR L 443
ILE L 447
 None
 1.30A 4l9qA-6ehsL:
0.7		 4l9qA-6ehsL:
7.85
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4lbxA-6ehsL:
undetectable		 4lbxA-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LBX_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 1.00A 4lbxB-6ehsL:
undetectable		 4lbxB-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_A_ADNA401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.98A 4lc4A-6ehsL:
undetectable		 4lc4A-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LC4_B_ADNB401_1
(PROBABLE SUGAR
KINASE PROTEIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 215
GLY L 210
GLY L 209
THR L  66
LEU L  70
 None
 0.99A 4lc4B-6ehsL:
undetectable		 4lc4B-6ehsL:
12.08
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LV9_B_20JB602_1
(NICOTINAMIDE
PHOSPHORIBOSYLTRANSF
ERASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 7 VAL L 536
ILE L   5
ARG L   4
ILE L  23
 None
 0.95A 4lv9B-6ehsL:
undetectable		 4lv9B-6ehsL:
10.37
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4LVC_B_ADNB501_2
(S-ADENOSYL-L-HOMOCYS
TEINE HYDROLASE
(SAHASE))		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 GLN L 406
THR L 409
THR L 262
LEU L 413
 None
 1.06A 4lvcB-6ehsL:
undetectable		 4lvcB-6ehsL:
10.55
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_E_TMQE202_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 247
ILE L 447
LEU L 235
LEU L 208
ILE L 243
 None
 1.06A 4m2xE-6ehsL:
undetectable		 4m2xE-6ehsL:
19.87
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QI9_C_MTXC201_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 11 ILE L  95
SER L 245
ILE L 247
LEU L 439
THR L 212
 None
 1.14A 4qi9C-6ehsL:
undetectable		 4qi9C-6ehsL:
19.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZBR_A_NPSA603_1
(SERUM ALBUMIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 LEU L 185
ALA L 130
SER L 121
LEU L 123
ALA L 122
 None
 1.19A 4zbrA-6ehsL:
undetectable		 4zbrA-6ehsL:
8.59
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_A_FOLA201_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
ILE L  94
THR L 212
 None
 1.10A 5e8qA-6ehsL:
undetectable		 5e8qA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5E8Q_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.06A 5e8qB-6ehsL:
undetectable		 5e8qB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5EAJ_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.09A 5eajB-6ehsL:
undetectable		 5eajB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HI6_B_MTXB201_1
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.06A 5hi6B-6ehsL:
undetectable		 5hi6B-6ehsL:
19.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5HQA_A_ACRA705_2
(ALPHA-GLUCOSIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 ASN L  93
TRP L  54
GLU L  77
THR L 100
 None
 1.36A 5hqaA-6ehsL:
undetectable		 5hqaA-6ehsL:
7.26
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5K7U_A_SAMA601_0
(N6-ADENOSINE-METHYLT
RANSFERASE 70 KDA
SUBUNIT)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L 166
ARG L  12
LEU L 114
PHE L 167
GLY L 165
 None
 1.35A 5k7uA-6ehsL:
undetectable		 5k7uA-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5M5C_B_TA1B502_1
(TUBULIN BETA-2B
CHAIN)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 GLU L 376
ALA L 307
ARG L 424
GLY L 423
LEU L 418
 None
 1.15A 5m5cB-6ehsL:
undetectable		 5m5cB-6ehsL:
11.27
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5O96_H_SAMH501_0
(RIBOSOMAL RNA SMALL
SUBUNIT
METHYLTRANSFERASE E)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 10 GLY L 516
GLY L 507
VAL L 377
THR L 374
ALA L 279
 None
 1.06A 5o96G-6ehsL:
undetectable
5o96H-6ehsL:
undetectable		 5o96G-6ehsL:
undetectable
5o96H-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5TT3_H_EZLH303_1
(ALPHA-CARBONIC
ANHYDRASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 8 HIS L  99
LEU L  70
THR L  67
ALA L  69
 None
None
FCO  L 601 (-4.2A)
None
 0.88A 5tt3H-6ehsL:
undetectable		 5tt3H-6ehsL:
16.88
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5UJX_B_FOLB201_0
(DIHYDROFOLATE
REDUCTASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 ILE L  95
ALA L 206
ILE L 247
LEU L 439
THR L 212
 None
 1.07A 5ujxB-6ehsL:
undetectable		 5ujxB-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_A_ACRA1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 TYR L 312
TYR L 303
GLY L 302
GLY L 301
 None
 0.95A 5x7pA-6ehsL:
undetectable		 5x7pA-6ehsL:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5X7P_B_ACRB1421_1
(GLYCOSIDE HYDROLASE
FAMILY 31
ALPHA-GLUCOSIDASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 6 TYR L 312
GLU L 305
TYR L 303
GLY L 302
GLY L 301
 None
 1.30A 5x7pB-6ehsL:
undetectable		 5x7pB-6ehsL:
5.91
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5YCP_A_BRLA501_0
(PEROXISOME
PROLIFERATOR-ACTIVAT
ED RECEPTOR GAMMA)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		5 / 12 PHE L 299
ILE L 315
HIS L 431
LEU L 435
LEU L  96
 None
 1.00A 5ycpA-6ehsL:
undetectable		 5ycpA-6ehsL:
18.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6APH_A_ADNA501_2
(ADENOSYLHOMOCYSTEINA
SE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 GLN L 406
THR L 409
THR L 262
LEU L 413
 None
 1.06A 6aphA-6ehsL:
undetectable		 6aphA-6ehsL:
10.98
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6DWD_C_GLYC713_0
(DEOXYNUCLEOSIDE
TRIPHOSPHATE
TRIPHOSPHOHYDROLASE
SAMHD1)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 GLN L 442
TYR L  90
ASN L  93
 None
 0.76A 6dwdC-6ehsL:
undetectable		 6dwdC-6ehsL:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_A_ADNA502_2
(-)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 GLN L 406
THR L 409
THR L 262
LEU L 413
 None
 1.09A 6f3mA-6ehsL:
undetectable		 6f3mA-6ehsL:
10.35
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6F3M_C_ADNC502_2
(-)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 4 GLN L 406
THR L 409
THR L 262
LEU L 413
 None
 1.08A 6f3mC-6ehsL:
undetectable		 6f3mC-6ehsL:
10.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6GBN_B_ADNB501_2
(-)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		4 / 5 GLN L 406
THR L 409
THR L 262
LEU L 413
 None
 1.06A 6gbnB-6ehsL:
undetectable		 6gbnB-6ehsL:
10.95
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6NCS_A_ACTA303_0
(N-ACETYLNEURAMINIC
ACID (SIALIC ACID)
SYNTHETASE)		 6ehs HYDROGENASE-2 LARGE
CHAIN
(Escherichia
coli) 		3 / 3 ILE L   5
THR L   6
PRO L 533
 None
 0.60A 6ncsA-6ehsL:
undetectable		 6ncsA-6ehsL:
undetectable