SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehx'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1H8S_A_AICA1000_1
(MUTANT AL2 6E7P9G)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		8 / 12 TYR B 172
GLN B 225
TYR B 230
LEU B 232
PHE B 234
VAL B  37
ALA B  97
TRP B 111
 None
 0.63A 1h8sA-6ehxB:
21.9		 1h8sA-6ehxB:
29.89
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
3LS4_H_TCIH220_2
(HEAVY CHAIN OF
ANTIBODY FAB
FRAGMENT
LIGHT CHAIN OF
ANTIBODY FAB
FRAGMENT)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		4 / 5 TYR B 172
GLN B 225
LEU B 232
PHE B 234
 None
 0.40A 3ls4L-6ehxB:
22.3		 3ls4L-6ehxB:
68.52
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EM2_A_SALA501_1
(UNCHARACTERIZED
HTH-TYPE
TRANSCRIPTIONAL
REGULATOR SAR2349)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		4 / 5 TYR B  94
LEU B  81
LEU B  86
ARG B  67
 None
 1.37A 4em2A-6ehxB:
undetectable		 4em2A-6ehxB:
18.18
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4M7K_H_ACTH302_0
(10H10 HEAVY CHAIN)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		4 / 5 VAL B   2
TYR B  27
ARG B  98
TYR B 110
 None
 0.28A 4m7kH-6ehxB:
20.9		 4m7kH-6ehxB:
42.63
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.
4UIL_H_QI9H1223_0
(FAB 314.1)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		5 / 12 HIS B  35
GLY B 101
PHE B 108
GLN B 225
GLN B 226
 None
 0.97A 4uilH-6ehxB:
19.9
4uilL-6ehxB:
20.1		 4uilH-6ehxB:
41.74
4uilL-6ehxB:
71.03
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5L4E_D_EDPD402_1
(PROTON-GATED ION
CHANNEL)		 6ehx SCFV ABVANCE:
INCREASING OUR
KNOWLEDGE OF
ANTIBODY STRUCTURAL
SPACE TO ENABLE
FASTER AND BETTER
DECISION MAKING IN
DRUG DISCOVERY
(Homo
sapiens) 		4 / 8 THR B 210
SER B 199
THR B 208
SER B 201
 None
 0.99A 5l4eA-6ehxB:
undetectable
5l4eB-6ehxB:
undetectable
5l4eC-6ehxB:
undetectable
5l4eD-6ehxB:
undetectable
5l4eE-6ehxB:
undetectable		 5l4eA-6ehxB:
18.58
5l4eB-6ehxB:
18.58
5l4eC-6ehxB:
18.58
5l4eD-6ehxB:
18.58
5l4eE-6ehxB:
18.58