SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ehy'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	1H8S_A_AICA1000_1 (MUTANT AL2 6E7P9G)	6ehy	SCFV ANTIBODY FRAGMENT (Homo sapiens)	8 / 12	TYR A 174 GLN A 227 TYR A 232 LEU A 234 PHE A 236 VAL A 37 ALA A 97 TRP A 111	None	0.64A	1h8sA-6ehyA: 22.5	1h8sA-6ehyA: 30.94
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OLD_B_IPHB2001_0 (BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN)	6ehy	SCFV ANTIBODY FRAGMENT (Homo sapiens)	4 / 7	TYR A 174 PRO A 182 TYR A 225 TYR A 95	None	0.74A	2oldA-6ehyA: 14.8 2oldB-6ehyA: 14.7	2oldA-6ehyA: 24.90 2oldB-6ehyA: 24.90
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	3LS4_H_TCIH220_2 (HEAVY CHAIN OF ANTIBODY FAB FRAGMENT LIGHT CHAIN OF ANTIBODY FAB FRAGMENT)	6ehy	SCFV ANTIBODY FRAGMENT (Homo sapiens)	4 / 5	TYR A 174 GLN A 227 LEU A 234 PHE A 236	None	0.41A	3ls4L-6ehyA: 21.7	3ls4L-6ehyA: 36.49
Available target for annotated drug, i.e. matched protein structure has more than 30% sequence identity to known drug target.	4M7K_H_ACTH302_0 (10H10 HEAVY CHAIN)	6ehy	SCFV ANTIBODY FRAGMENT (Homo sapiens)	4 / 5	VAL A 2 TYR A 27 ARG A 98 TYR A 110	None	0.28A	4m7kH-6ehyA: 21.4	4m7kH-6ehyA: 42.02
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5TZO_B_7V7B201_1 (ENDO-1,4-BETA-XYLANA SE A)	6ehy	SCFV ANTIBODY FRAGMENT (Homo sapiens)	5 / 12	LEU A 45 SER A 35 VAL A 37 ALA A 61 GLY A 49	None	1.19A	5tzoB-6ehyA: undetectable	5tzoB-6ehyA: 22.96

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H8S_A_AICA1000_1","MUTANT AL2 6E7P9G","6ehy","SCFV ANTIBODY FRAGMENT","Homo sapiens",8,"TYR A 174;GLN A 227;TYR A 232;LEU A 234;PHE A 236;VAL A  37;ALA A  97;TRP A 111","None","0.64A","1h8sA-6ehyA:22.5","1h8sA-6ehyA:30.94"],["2OLD_B_IPHB2001_0","BENCE JONES KWR PROTEIN - IMMUNOGLOBULIN LIGHT CHAIN","6ehy","SCFV ANTIBODY FRAGMENT","Homo sapiens",4,"TYR A 174;PRO A 182;TYR A 225;TYR A  95","None","0.74A","2oldA-6ehyA:14.8;2oldB-6ehyA:14.7","2oldA-6ehyA:24.90;2oldB-6ehyA:24.90"],["3LS4_H_TCIH220_2","HEAVY CHAIN OF ANTIBODY FAB FRAGMENT;LIGHT CHAIN OF ANTIBODY FAB FRAGMENT","6ehy","SCFV ANTIBODY FRAGMENT","Homo sapiens",4,"TYR A 174;GLN A 227;LEU A 234;PHE A 236","None","0.41A","3ls4L-6ehyA:21.7","3ls4L-6ehyA:36.49"],["4M7K_H_ACTH302_0","10H10 HEAVY CHAIN","6ehy","SCFV ANTIBODY FRAGMENT","Homo sapiens",4,"VAL A   2;TYR A  27;ARG A  98;TYR A 110","None","0.28A","4m7kH-6ehyA:21.4","4m7kH-6ehyA:42.02"],["5TZO_B_7V7B201_1","ENDO-1,4-BETA-XYLANASE A","6ehy","SCFV ANTIBODY FRAGMENT","Homo sapiens",5,"LEU A  45;SER A  35;VAL A  37;ALA A  61;GLY A  49","None","1.19A","5tzoB-6ehyA:undetectable","5tzoB-6ehyA:22.96"]]