SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ei9'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1DYR_A_TOPA407_1
(DIHYDROFOLATE
REDUCTASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 11 ILE A  13
LEU A 213
ILE A 203
ILE A 186
ILE A 198
 None
 0.98A 1dyrA-6ei9A:
undetectable		 1dyrA-6ei9A:
17.62
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1HSH_C_MK1C402_1
(HIV-II PROTEASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 217
ALA A 218
ASP A 219
ILE A 168
ILE A 186
 None
 0.94A 1hshC-6ei9A:
undetectable		 1hshC-6ei9A:
18.10
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1T88_B_CAMB2422_0
(CYTOCHROME P450-CAM)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 5 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.22A 1t88B-6ei9A:
undetectable		 1t88B-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2B60_B_RITB100_2
(GAG-POL POLYPROTEIN)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 11 GLY A 217
ALA A 218
ASP A 219
ILE A 168
ILE A 186
 None
 0.97A 2b60B-6ei9A:
undetectable		 2b60B-6ei9A:
20.39
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2HS1_A_017A201_1
(HIV-1 PROTEASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 217
ALA A 218
ASP A 219
ILE A 168
ILE A 186
 None
 1.02A 2hs1A-6ei9A:
undetectable		 2hs1A-6ei9A:
17.17
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 GLY A 217
ALA A 218
ASP A 219
ILE A 168
ILE A 186
 None
 0.94A 2rkgB-6ei9A:
undetectable		 2rkgB-6ei9A:
17.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZLC_A_VDXA500_1
(VITAMIN D3 RECEPTOR)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 12 LEU A 287
HIS A 262
LEU A 266
HIS A 282
LEU A  28
 None
 1.28A 2zlcA-6ei9A:
undetectable		 2zlcA-6ei9A:
14.67
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3FWG_A_CAMA420_0
(CAMPHOR
5-MONOOXYGENASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.12A 3fwgA-6ei9A:
undetectable		 3fwgA-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HBB_C_TMQC613_1
(DIHYDROFOLATE
REDUCTASE-THYMIDYLAT
E SYNTHASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		5 / 11 VAL A 212
ALA A 218
ILE A 198
PRO A  16
ILE A 203
 None
None
None
FMN  A 401 (-3.9A)
None
 1.05A 3hbbC-6ei9A:
undetectable		 3hbbC-6ei9A:
9.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRH_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.13A 3wrhE-6ei9A:
undetectable		 3wrhE-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3WRJ_E_CAME503_0
(CAMPHOR
5-MONOOXYGENASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.14A 3wrjE-6ei9A:
undetectable		 3wrjE-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4EK1_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 6 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.08A 4ek1A-6ei9A:
undetectable		 4ek1A-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_B_ACTB701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		3 / 3 HIS A 282
GLY A  19
ILE A  20
 None
None
FMN  A 401 ( 4.6A)
 0.64A 4k50A-6ei9A:
undetectable		 4k50A-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4K50_J_ACTJ701_0
(RNA (33-MER)
RNA POLYMERASE
3D-POL)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		3 / 3 HIS A 282
GLY A  19
ILE A  20
 None
None
FMN  A 401 ( 4.6A)
 0.63A 4k50I-6ei9A:
undetectable		 4k50I-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4L49_A_CAMA502_0
(CAMPHOR
5-MONOOXYGENASE)		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 5 PHE A 317
TYR A 316
LEU A 287
VAL A 283
 None
 1.21A 4l49A-6ei9A:
undetectable		 4l49A-6ei9A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4QOG_A_ML1A302_1
(RIBOSYLDIHYDRONICOTI
NAMIDE DEHYDROGENASE
[QUINONE])		 6ei9 TRNA-DIHYDROURIDINE
SYNTHASE B
(Escherichia
coli) 		4 / 8 ILE A 140
PHE A 177
GLY A 170
ILE A 186
 None
GOL  A 402 (-3.9A)
None
None
 0.95A 4qogA-6ei9A:
undetectable
4qogB-6ei9A:
undetectable		 4qogA-6ei9A:
16.74
4qogB-6ei9A:
16.74