SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6eic'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CD2_A_FOLA307_1
(DIHYDROFOLATE
REDUCTASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		3 / 3 GLU C 250
ILE C 231
ARG C 236
 None
 0.84A 1cd2A-6eicC:
undetectable		 1cd2A-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1P2Y_A_NCTA440_1
(CYTOCHROME P450-CAM)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 7 VAL C  92
GLY C  93
ASP C 128
VAL C  32
 None
 0.80A 1p2yA-6eicC:
undetectable		 1p2yA-6eicC:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 11 LEU C 214
VAL C 121
GLY C 120
VAL C 137
VAL C 203
 None
 1.22A 1phgA-6eicC:
undetectable		 1phgA-6eicC:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1PHG_A_MYTA422_1
(CYTOCHROME P450-CAM)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 11 THR C 206
LEU C 214
VAL C 121
GLY C 120
VAL C 137
 None
 1.13A 1phgA-6eicC:
undetectable		 1phgA-6eicC:
12.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S3Z_B_RIOB501_0
(AMINOGLYCOSIDE
6'-N-ACETYLTRANSFERA
SE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 8 GLU C 122
VAL C 121
ARG C 198
GLU C 205
 None
 1.09A 1s3zA-6eicC:
undetectable
1s3zB-6eicC:
undetectable		 1s3zA-6eicC:
undetectable
1s3zB-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1S9Q_A_CHDA459_0
(ESTROGEN-RELATED
RECEPTOR GAMMA)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 6 LEU C 107
VAL C 106
ILE C 105
TYR C 251
 None
 0.92A 1s9qA-6eicC:
undetectable		 1s9qA-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BXE_B_1FLB2001_1
(SERUM ALBUMIN)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 12 LEU C 218
VAL C 137
GLY C 114
LEU C 237
SER C 243
 None
 1.28A 2bxeB-6eicC:
undetectable		 2bxeB-6eicC:
10.36
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_A_SALA2006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 1.01A 2e1qA-6eicC:
undetectable		 2e1qA-6eicC:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2E1Q_C_SALC4006_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 6 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 0.98A 2e1qC-6eicC:
undetectable		 2e1qC-6eicC:
4.58
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3AQI_B_CHDB5_0
(FERROCHELATASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		3 / 3 PRO C 185
LEU C 186
ARG C  44
 None
 0.83A 3aqiB-6eicC:
3.6		 3aqiB-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BGD_B_PM6B301_1
(THIOPURINE
S-METHYLTRANSFERASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 8 GLY C 114
VAL C 137
LEU C 237
PRO C 135
 None
 1.08A 3bgdB-6eicC:
undetectable		 3bgdB-6eicC:
12.74
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EM4_V_DR7V100_1
(PROTEASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		6 / 11 ALA C 199
ASP C  80
GLY C 155
LEU C 154
VAL C 192
ILE C 196
 None
 1.42A 3em4U-6eicC:
undetectable		 3em4U-6eicC:
19.79
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_A_SAMA6735_0
(16S RRNA METHYLASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY C 197
GLY C 195
ALA C 139
LEU C 154
LEU C 201
 None
 1.05A 3p2kA-6eicC:
undetectable		 3p2kA-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3P2K_B_SAMB6735_0
(16S RRNA METHYLASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY C 197
GLY C 195
ALA C 139
LEU C 154
LEU C 201
 None
 1.17A 3p2kB-6eicC:
2.6		 3p2kB-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3UNI_A_SALA1344_1
(XANTHINE
DEHYDROGENASE/OXIDAS
E)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 7 ARG C  52
VAL C 271
LEU C 275
ALA C  56
 None
 0.93A 3uniA-6eicC:
undetectable		 3uniA-6eicC:
5.54
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4BBO_D_ACTD1113_0
(BLR5658 PROTEIN)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 4 TRP C 274
LEU C 129
LEU C 279
THR C 276
 None
 1.43A 4bboD-6eicC:
undetectable		 4bboD-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4MM6_A_29EA603_1
(TRANSPORTER)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 12 VAL C 137
ALA C 136
PHE C 117
VAL C 116
GLY C 113
 None
SO4  C 301 ( 4.0A)
None
None
None
 0.93A 4mm6A-6eicC:
undetectable		 4mm6A-6eicC:
8.48
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4RTM_A_SAMA301_0
(DNA ADENINE
METHYLASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 12 GLY C 112
GLY C 114
ALA C 136
ILE C 171
SER C 172
 None
None
SO4  C 301 ( 4.0A)
MPD  C 302 ( 4.6A)
None
 0.94A 4rtmA-6eicC:
2.4		 4rtmA-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4ZE0_A_VORA602_1
(LANOSTEROL 14-ALPHA
DEMETHYLASE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 9 TYR C 127
ILE C 105
PHE C  88
GLY C 108
LEU C 214
 None
 1.16A 4ze0A-6eicC:
undetectable		 4ze0A-6eicC:
9.70
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_A_ADNA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 5 GLU C 277
THR C 276
HIS C 109
LEU C 221
 None
None
MPD  C 302 (-4.3A)
None
 1.25A 5axaA-6eicC:
undetectable		 5axaA-6eicC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXA_C_ADNC502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 5 GLU C 277
THR C 276
HIS C 109
LEU C 221
 None
None
MPD  C 302 (-4.3A)
None
 1.25A 5axaC-6eicC:
3.0		 5axaC-6eicC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5AXD_A_RBVA502_2
(ADENOSYLHOMOCYSTEINA
SE)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		3 / 3 THR C   3
HIS C 109
LEU C  35
 None
MPD  C 302 (-4.3A)
None
 0.71A 5axdA-6eicC:
6.7		 5axdA-6eicC:
10.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5CP4_A_CAMA422_0
(CYTOCHROME P450CAM)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		5 / 9 LEU C 214
VAL C 121
GLY C 120
VAL C 137
VAL C 203
 None
 1.25A 5cp4A-6eicC:
undetectable		 5cp4A-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_P_BEZP801_1
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 6 SER C 110
ALA C 136
HIS C 109
LEU C 228
 MPD  C 302 (-3.3A)
SO4  C 301 ( 4.0A)
MPD  C 302 (-4.3A)
SO4  C 301 ( 4.4A)
 0.99A 5dzkB-6eicC:
3.1
5dzkP-6eicC:
undetectable		 5dzkB-6eicC:
undetectable
5dzkP-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_R_BEZR801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 7 SER C 110
ALA C 136
HIS C 109
LEU C 228
 MPD  C 302 (-3.3A)
SO4  C 301 ( 4.0A)
MPD  C 302 (-4.3A)
SO4  C 301 ( 4.4A)
 0.89A 5dzkD-6eicC:
2.4
5dzkR-6eicC:
undetectable		 5dzkD-6eicC:
undetectable
5dzkR-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_T_BEZT801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 5 SER C 110
ALA C 136
HIS C 109
LEU C 228
 MPD  C 302 (-3.3A)
SO4  C 301 ( 4.0A)
MPD  C 302 (-4.3A)
SO4  C 301 ( 4.4A)
 0.97A 5dzkf-6eicC:
3.4
5dzkt-6eicC:
undetectable		 5dzkf-6eicC:
undetectable
5dzkt-6eicC:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5IKQ_A_JMSA602_2
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		3 / 3 VAL C  49
SER C 133
MET C 130
 None
 0.84A 5ikqA-6eicC:
undetectable		 5ikqA-6eicC:
10.45
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6FGD_A_ACTA824_0
(GEPHYRIN)		 6eic MYCOBACTERIUM
TUBERCULOSIS
MONOGLYCERIDE LIPASE
(Mycobacterium
tuberculosis) 		4 / 4 LEU C 129
ASP C 245
PRO C 217
ARG C 278
 None
 1.29A 6fgdA-6eicC:
3.6		 6fgdA-6eicC:
undetectable