SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ej2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1CLA_A_CLMA221_0
(TYPE III
CHLORAMPHENICOL
ACETYLTRANSFERASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 10 PHE A 670
ALA A 653
LEU A 643
VAL A 745
ILE A 692
 None
 1.32A 1claA-6ej2A:
undetectable		 1claA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1D1G_A_MTXA171_1
(DIHYDROFOLATE
REDUCTASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 632
GLU A 534
ILE A 535
ARG A 537
ILE A 635
 None
None
None
B7E  A 901 (-3.9A)
None
 1.22A 1d1gA-6ej2A:
undetectable		 1d1gA-6ej2A:
19.28
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_B_SAMB500_1
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 ASN A 618
SER A 693
ARG A 706
ALA A 660
 None
 0.94A 1rqpC-6ej2A:
undetectable		 1rqpC-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1RQP_C_SAMC500_0
(5'-FLUORO-5'-DEOXYAD
ENOSINE SYNTHASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 ASN A 618
SER A 693
ARG A 706
ALA A 660
 None
 0.97A 1rqpA-6ej2A:
undetectable		 1rqpA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1YA3_B_STRB2001_2
(MINERALOCORTICOID
RECEPTOR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 LEU A 530
LEU A 439
MET A 427
 None
B7E  A 901 (-4.6A)
None
 0.53A 1ya3B-6ej2A:
undetectable		 1ya3B-6ej2A:
17.32
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 622
LEU A 645
PHE A 650
SER A 734
ILE A 657
 None
 1.12A 2oipA-6ej2A:
undetectable		 2oipA-6ej2A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2OIP_D_MTXD617_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 622
LEU A 645
PHE A 650
SER A 734
ILE A 657
 None
 1.02A 2oipD-6ej2A:
undetectable		 2oipD-6ej2A:
9.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PO5_A_CHDA501_0
(FERROCHELATASE,
MITOCHONDRIAL)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 696
ILE A 761
LEU A 645
PRO A 646
VAL A 649
 None
 1.06A 2po5A-6ej2A:
undetectable		 2po5A-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYM_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 439
ASP A 441
GLY A 443
ASN A 446
ILE A 527
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 (-4.2A)
B7E  A 901 (-4.4A)
 0.78A 2pymA-6ej2A:
6.7		 2pymA-6ej2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_1
(PROTEASE RETROPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 439
ASP A 441
GLY A 443
ASN A 446
ILE A 527
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 (-4.2A)
B7E  A 901 (-4.4A)
 0.77A 2pynA-6ej2A:
6.8		 2pynA-6ej2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2PYN_A_1UNA1001_2
(PROTEASE RETROPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 439
ASP A 441
GLY A 443
ASN A 446
ILE A 527
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 (-4.2A)
B7E  A 901 (-4.4A)
 0.78A 2pynB-6ej2A:
6.8		 2pynB-6ej2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2QAK_A_1UNA1001_3
(PROTEASE RETROPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 439
ASP A 441
GLY A 443
ASN A 446
ILE A 527
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 (-4.2A)
B7E  A 901 (-4.4A)
 0.79A 2qakB-6ej2A:
6.6		 2qakB-6ej2A:
25.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2RKG_B_AB1B501_2
(PROTEASE RETROPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 439
ASP A 441
GLY A 443
VAL A 478
ILE A 527
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
B7E  A 901 (-4.4A)
 0.66A 2rkgB-6ej2A:
6.9		 2rkgB-6ej2A:
19.42
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 441
GLY A 443
SER A 444
ASP A 637
GLY A 639
 B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
B7E  A 901 ( 3.7A)
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
 0.34A 2v0zC-6ej2A:
33.9		 2v0zC-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_C_C41C1328_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		6 / 12 ASP A 637
GLY A 639
VAL A 741
ASP A 441
GLY A 443
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
 1.04A 2v0zC-6ej2A:
33.9		 2v0zC-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V0Z_O_C41O1327_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		6 / 12 ASP A 637
GLY A 639
VAL A 741
ASP A 441
GLY A 443
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-2.9A)
B7E  A 901 ( 3.8A)
None
 1.03A 2v0zO-6ej2A:
34.1		 2v0zO-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2V7U_A_SAMA1299_0
(5'-FLUORO-5'-DEOXY
ADENOSINE SYNTHETASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 ASN A 618
SER A 693
ARG A 706
ALA A 660
 None
 0.95A 2v7uA-6ej2A:
undetectable		 2v7uA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2ZBP_A_SAMA300_0
(RIBOSOMAL PROTEIN
L11
METHYLTRANSFERASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 GLY A 743
GLY A 422
LEU A 563
ILE A 519
LEU A 439
 None
B7E  A 901 (-3.8A)
None
None
B7E  A 901 (-4.6A)
 1.07A 2zbpA-6ej2A:
undetectable		 2zbpA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3BUF_A_AEGA394_0
(BETA-SECRETASE 1)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 5 LEU A 439
ASP A 441
ILE A 519
ILE A 527
GLY A 639
 B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
None
B7E  A 901 (-4.4A)
B7E  A 901 (-3.8A)
 0.39A 3bufA-6ej2A:
59.6		 3bufA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_A_REMA350_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 637
GLY A 639
LEU A 439
ASP A 441
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
None
 0.70A 3d91A-6ej2A:
15.2		 3d91A-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 637
GLY A 639
LEU A 439
ASP A 441
SER A 445
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
None
 0.71A 3d91B-6ej2A:
33.8		 3d91B-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3D91_B_REMB350_1
(RENIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ASP A 637
GLY A 639
VAL A 741
LEU A 439
ASP A 441
 B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
None
B7E  A 901 (-4.6A)
B7E  A 901 (-2.9A)
 0.79A 3d91B-6ej2A:
33.8		 3d91B-6ej2A:
13.38
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3EKQ_A_ROCA100_2
(PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 9 LEU A 694
VAL A 779
GLY A 762
ILE A 761
ILE A 707
 None
 1.07A 3ekqB-6ej2A:
6.2		 3ekqB-6ej2A:
22.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_A_ADNA300_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TYR A 424
GLY A 450
VAL A 449
GLY A 526
HIS A 458
 None
 1.03A 3f8wA-6ej2A:
undetectable		 3f8wA-6ej2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3F8W_B_ADNB301_1
(PURINE-NUCLEOSIDE
PHOSPHORYLASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TYR A 424
GLY A 450
VAL A 449
GLY A 526
HIS A 458
 None
 1.04A 3f8wB-6ej2A:
undetectable		 3f8wB-6ej2A:
14.23
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HGI_A_BEZA284_0
(CATECHOL
1,2-DIOXYGENASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 530
ASP A 441
VAL A 440
GLY A 443
TYR A 608
 None
B7E  A 901 (-2.9A)
None
B7E  A 901 ( 3.8A)
None
 1.36A 3hgiA-6ej2A:
undetectable		 3hgiA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_A_MTXA605_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 622
LEU A 645
PHE A 650
SER A 734
ILE A 657
 None
 1.12A 3hj3A-6ej2A:
undetectable		 3hj3A-6ej2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HJ3_B_MTXB609_1
(CHAIN A, CRYSTAL
STRUCTURE OF DHFR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 LEU A 622
LEU A 645
PHE A 650
SER A 734
ILE A 657
 None
 1.10A 3hj3B-6ej2A:
undetectable		 3hj3B-6ej2A:
9.53
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3HS6_B_EPAB1_1
(PROSTAGLANDIN G/H
SYNTHASE 2)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TYR A 599
ASN A 414
ILE A 496
GLY A 586
LEU A 561
 None
 0.99A 3hs6B-6ej2A:
undetectable		 3hs6B-6ej2A:
8.72
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3JW5_A_TOPA208_1
(DIHYDROFOLATE
REDUCTASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 11 MET A 624
LEU A 694
LEU A 645
VAL A 649
ILE A 617
 None
 1.32A 3jw5A-6ej2A:
undetectable		 3jw5A-6ej2A:
20.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3PWW_A_ROCA1001_2
(ENDOTHIAPEPSIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 8 GLY A 443
SER A 444
ASP A 637
THR A 641
 B7E  A 901 ( 3.8A)
B7E  A 901 ( 3.7A)
B7E  A 901 (-2.6A)
None
 0.30A 3pwwA-6ej2A:
9.0		 3pwwA-6ej2A:
13.18
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3Q70_A_RITA2001_1
(CANDIDAPEPSIN-2)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 635
ASP A 637
GLY A 639
ASP A 441
ILE A 527
 None
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-2.9A)
B7E  A 901 (-4.4A)
 0.65A 3q70A-6ej2A:
31.9		 3q70A-6ej2A:
13.16
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_A_RITA401_1
(SECRETED ASPARTIC
PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 635
ASP A 637
GLY A 639
ASP A 441
ILE A 527
 None
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-2.9A)
B7E  A 901 (-4.4A)
 0.64A 3tneA-6ej2A:
32.2		 3tneA-6ej2A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_1
(SECRETED ASPARTIC
PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 635
ASP A 637
GLY A 639
ASP A 441
ILE A 527
 None
B7E  A 901 (-2.6A)
B7E  A 901 (-3.8A)
B7E  A 901 (-2.9A)
B7E  A 901 (-4.4A)
 0.67A 3tneB-6ej2A:
32.0		 3tneB-6ej2A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3TNE_B_RITB401_2
(SECRETED ASPARTIC
PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 7 SER A 444
ILE A 527
THR A 640
THR A 641
 B7E  A 901 ( 3.7A)
B7E  A 901 (-4.4A)
None
None
 0.39A 3tneB-6ej2A:
32.1		 3tneB-6ej2A:
11.68
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3W68_A_VIVA301_0
(ALPHA-TOCOPHEROL
TRANSFER PROTEIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 TRP A 671
VAL A 654
ILE A 692
VAL A 615
LEU A 694
 None
 1.01A 3w68A-6ej2A:
undetectable		 3w68A-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4FUB_A_ACTA311_0
(UROKINASE-TYPE
PLASMINOGEN
ACTIVATOR)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 TYR A 424
ARG A 459
HIS A 458
 None
 0.90A 4fubA-6ej2A:
undetectable		 4fubA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4M2X_G_TMQG202_1
(DIHYDROFOLATE
REDUCTASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ILE A 707
LEU A 645
PRO A 646
VAL A 649
THR A 600
 None
 1.05A 4m2xG-6ej2A:
undetectable		 4m2xG-6ej2A:
20.75
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4OQR_A_2UOA502_1
(CYP105AS1)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 9 VAL A 504
ILE A 527
VAL A 449
ALA A 448
ALA A 506
 None
B7E  A 901 (-4.4A)
None
None
None
 1.19A 4oqrA-6ej2A:
undetectable		 4oqrA-6ej2A:
12.69
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 ASP A 441
ASP A 637
ASN A 642
 B7E  A 901 (-2.9A)
B7E  A 901 (-2.6A)
None
 0.63A 4q5mA-6ej2A:
9.1		 4q5mA-6ej2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Q5M_A_ROCA1101_3
(PROTEASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 ASP A 637
ASP A 441
ASN A 446
 B7E  A 901 (-2.6A)
B7E  A 901 (-2.9A)
B7E  A 901 (-4.2A)
 0.50A 4q5mA-6ej2A:
9.1		 4q5mA-6ej2A:
21.20
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4WNU_A_QDNA602_1
(CYTOCHROME P450 2D6)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 11 LEU A 542
GLY A 529
LEU A 530
PHE A 447
ALA A 506
 None
 1.21A 4wnuA-6ej2A:
undetectable		 4wnuA-6ej2A:
13.07
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4Z4I_A_IPHA903_0
(PROTEIN ARGONAUTE-2)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		3 / 3 VAL A 449
ALA A 451
PHE A 518
 None
 0.92A 4z4iA-6ej2A:
undetectable		 4z4iA-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5BW4_B_SAMB301_0
(16S RRNA
(ADENINE(1408)-N(1))
-METHYLTRANSFERASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 GLY A 529
PRO A 544
ALA A 536
LEU A 439
LEU A 530
 None
None
None
B7E  A 901 (-4.6A)
None
 1.21A 5bw4B-6ej2A:
undetectable		 5bw4B-6ej2A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5KQX_A_ROCA101_2
(PROTEASE E35D-SQV)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 9 LEU A 694
VAL A 779
GLY A 762
ILE A 761
ILE A 707
 None
 1.13A 5kqxB-6ej2A:
6.5		 5kqxB-6ej2A:
21.21
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5MRA_B_DM2B204_1
(SORCIN)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		4 / 6 THR A 738
ARG A 644
ASP A 637
GLY A 443
 None
None
B7E  A 901 (-2.6A)
B7E  A 901 ( 3.8A)
 1.19A 5mraA-6ej2A:
undetectable
5mraB-6ej2A:
undetectable		 5mraA-6ej2A:
20.96
5mraB-6ej2A:
20.96
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
6CLX_A_SAMA401_0
(O-METHYLTRANSFERASE)		 6ej2 BETA-SECRETASE 1
(Homo
sapiens) 		5 / 12 ARG A 758
ALA A 757
GLY A 586
SER A 407
PHE A 408
 None
 1.23A 6clxA-6ej2A:
undetectable		 6clxA-6ej2A:
undetectable