SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ek2'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)

Filter list by:

	DrReposER ID / Desc.	Hit PDBID	Hit Macromolecule	Res. Matches	Interface	HETATM	RMSD	Dali Z-score	Seq. Identity (%)	View	Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	1H8S_A_AICA1000_1 (MUTANT AL2 6E7P9G)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	6 / 12	TYR H 374 GLN H 427 PHE H 436 VAL H 206 ALA H 266 TRP H 279	None	0.80A	1h8sA-6ek2H: 21.8	1h8sA-6ek2H: 27.56
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2OXT_C_SAMC300_1 (NUCLEOSIDE-2'-O-METH YLTRANSFERASE)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	4 / 4	SER H 387 GLY H 388 HIS H 204 ASP H 222	None	1.33A	2oxtC-6ek2H: undetectable	2oxtC-6ek2H: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	2ZI9_A_CL9A401_2 (DEOXYCYTIDINE KINASE)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	3 / 3	ASP H 268 PHE H 276 LEU H 384	None	0.73A	2zi9A-6ek2H: undetectable	2zi9A-6ek2H: 15.29
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3IJX_H_HCZH800_1 (GLUTAMATE RECEPTOR 2)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	4 / 5	LYS H 182 PRO H 183 SER H 257 SER H 254	None	1.44A	3ijxH-6ek2H: undetectable	3ijxH-6ek2H: 18.47
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	3LCV_B_SAMB301_0 (SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	5 / 12	TYR H 202 ALA H 218 ILE H 220 LEU H 250 LEU H 230	None	1.14A	3lcvB-6ek2H: undetectable	3lcvB-6ek2H: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4EM2_A_SALA501_1 (UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	4 / 5	TYR H 263 LEU H 250 LEU H 255 ARG H 236	None	1.33A	4em2A-6ek2H: undetectable	4em2A-6ek2H: 19.19
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	4L3G_F_ACTF401_0 (METHYLAMINE DEHYDROGENASE HEAVY CHAIN)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	3 / 3	ARG H 383 LEU H 385 GLU H 393	None	0.74A	4l3gF-6ek2H: undetectable	4l3gF-6ek2H: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_B_6K9B503_0 (TUBULIN BETA-2B CHAIN)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	5 / 11	VAL H 206 THR H 219 TYR H 264 PRO H 382 LEU H 214	None	1.41A	5jh7B-6ek2H: undetectable	5jh7B-6ek2H: undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.	5JH7_D_6K9D502_0 (TUBULIN BETA-2B CHAIN)	6ek2	SINGLE CHAIN FV FRAGMENT (Mus musculus)	5 / 11	VAL H 206 THR H 219 TYR H 264 PRO H 382 LEU H 214	None	1.38A	5jh7D-6ek2H: undetectable	5jh7D-6ek2H: undetectable

[["DrReposER ID","Desc.","Hit PDB","Hit molecule","Hit organism","Res. no.","Interface","HETATM","RMSD","Z-score","Seq ID"],["1H8S_A_AICA1000_1","MUTANT AL2 6E7P9G","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",6,"TYR H 374;GLN H 427;PHE H 436;VAL H 206;ALA H 266;TRP H 279","None","0.80A","1h8sA-6ek2H:21.8","1h8sA-6ek2H:27.56"],["2OXT_C_SAMC300_1","NUCLEOSIDE-2'-O-METHYLTRANSFERASE","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",4,"SER H 387;GLY H 388;HIS H 204;ASP H 222","None","1.33A","2oxtC-6ek2H:undetectable","2oxtC-6ek2H:undetectable"],["2ZI9_A_CL9A401_2","DEOXYCYTIDINE KINASE","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",3,"ASP H 268;PHE H 276;LEU H 384","None","0.73A","2zi9A-6ek2H:undetectable","2zi9A-6ek2H:15.29"],["3IJX_H_HCZH800_1","GLUTAMATE RECEPTOR 2","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",4,"LYS H 182;PRO H 183;SER H 257;SER H 254","None","1.44A","3ijxH-6ek2H:undetectable","3ijxH-6ek2H:18.47"],["3LCV_B_SAMB301_0","SISOMICIN-GENTAMICIN RESISTANCE METHYLASE SGM","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",5,"TYR H 202;ALA H 218;ILE H 220;LEU H 250;LEU H 230","None","1.14A","3lcvB-6ek2H:undetectable","3lcvB-6ek2H:undetectable"],["4EM2_A_SALA501_1","UNCHARACTERIZED HTH-TYPE TRANSCRIPTIONAL REGULATOR SAR2349","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",4,"TYR H 263;LEU H 250;LEU H 255;ARG H 236","None","1.33A","4em2A-6ek2H:undetectable","4em2A-6ek2H:19.19"],["4L3G_F_ACTF401_0","METHYLAMINE DEHYDROGENASE HEAVY CHAIN","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",3,"ARG H 383;LEU H 385;GLU H 393","None","0.74A","4l3gF-6ek2H:undetectable","4l3gF-6ek2H:undetectable"],["5JH7_B_6K9B503_0","TUBULIN BETA-2B CHAIN","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",5,"VAL H 206;THR H 219;TYR H 264;PRO H 382;LEU H 214","None","1.41A","5jh7B-6ek2H:undetectable","5jh7B-6ek2H:undetectable"],["5JH7_D_6K9D502_0","TUBULIN BETA-2B CHAIN","6ek2","SINGLE CHAIN FV FRAGMENT","Mus musculus",5,"VAL H 206;THR H 219;TYR H 264;PRO H 382;LEU H 214","None","1.38A","5jh7D-6ek2H:undetectable","5jh7D-6ek2H:undetectable"]]