SIMILAR PATTERN OF AMINO ACIDS MAPPED TO '6ek4'

List of Similar Pattern of Amino Acids

Hit pattern: 3D amino acid arrangements similar to known drug binding site
Query pattern: Residues from known binding site for annotated drug that match the hit pattern

(Click on the DrReposER ID to view details on interfaces and similar patterns of amino acids)
(Click on the view link on the last column to view superposed patterns of amino acids)
Filter list by:
DrReposER ID / Desc. Hit
PDBID		 Hit
Macromolecule		 Res.
Matches		 Interface HETATM RMSD Dali
Z-score		 Seq.
Identity (%)		 View Dock
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_A_CHDA1150_0
(ALCOHOL
DEHYDROGENASE)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 11 SER A  54
LEU A 298
LEU A 146
VAL A 140
ILE A 145
 None
 1.22A 1ee2A-6ek4A:
undetectable		 1ee2A-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
1EE2_B_CHDB1250_1
(ALCOHOL
DEHYDROGENASE)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 11 SER A  54
LEU A 298
LEU A 146
VAL A 140
ILE A 145
 None
 1.24A 1ee2B-6ek4A:
undetectable		 1ee2B-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2BM9_A_SAMA301_1
(CEPHALOSPORIN
HYDROXYLASE CMCI)		 6ek4 PAXB
(Photorhabdus
luminescens) 		3 / 3 LYS A 174
ASP A 270
ASN A 265
 None
 1.07A 2bm9A-6ek4A:
undetectable		 2bm9A-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_A_BEZA1002_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 10 LEU A 275
GLY A 277
ILE A 282
ARG A 159
ILE A 163
 None
 0.93A 2f8dA-6ek4A:
undetectable		 2f8dA-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
2F8D_B_BEZB1003_0
(HTH-TYPE
TRANSCRIPTIONAL
REGULATOR BENM)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 10 LEU A 275
GLY A 277
ILE A 282
ARG A 159
ILE A 163
 None
 0.95A 2f8dB-6ek4A:
undetectable		 2f8dB-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3A9E_B_REAB1_1
(RETINOIC ACID
RECEPTOR ALPHA)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 11 SER A  64
LEU A 340
SER A 125
VAL A  19
LEU A  22
 None
 1.24A 3a9eB-6ek4A:
undetectable		 3a9eB-6ek4A:
14.50
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
3VRJ_A_1KXA301_1
(HLA CLASS I
HISTOCOMPATIBILITY
ANTIGEN, B-57 ALPHA
CHAIN
10-MER PEPTIDE)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 12 TYR A 194
ILE A 191
VAL A 190
SER A 187
ILE A 204
 None
 1.26A 3vrjA-6ek4A:
undetectable
3vrjC-6ek4A:
undetectable		 3vrjA-6ek4A:
17.24
3vrjC-6ek4A:
17.24
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
4J24_A_ESTA600_1
(ESTROGEN RECEPTOR
BETA)		 6ek4 PAXB
(Photorhabdus
luminescens) 		5 / 12 LEU A 149
LEU A 146
ARG A 295
ILE A  40
ILE A  42
 None
 1.10A 4j24A-6ek4A:
undetectable		 4j24A-6ek4A:
15.00
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_4_BEZ4801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 2
BEZ-LEU-LEU)		 6ek4 PAXB
(Photorhabdus
luminescens) 		4 / 5 LEU A  32
ARG A 295
ILE A  29
ILE A  50
 None
 1.04A 5dzk4-6ek4A:
undetectable
5dzkg-6ek4A:
undetectable
5dzkm-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable		 5dzk4-6ek4A:
undetectable
5dzkg-6ek4A:
undetectable
5dzkm-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable
Potential target for repurposing, i.e. matched protein structure has less than 30% sequence identity to known drug target, and may potentially interact with the same drug molecule based on local structural similarity of binding site.
5DZK_V_BEZV801_0
(ATP-DEPENDENT CLP
PROTEASE PROTEOLYTIC
SUBUNIT 1
BEZ-LEU-LEU)		 6ek4 PAXB
(Photorhabdus
luminescens) 		4 / 4 ILE A  29
ILE A  50
ARG A 295
LEU A  32
 None
 1.14A 5dzkh-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable
5dzkv-6ek4A:
undetectable		 5dzkh-6ek4A:
undetectable
5dzkn-6ek4A:
undetectable
5dzkv-6ek4A:
undetectable